Invited Discussion on: A Single Center, Randomized, Double-blind Clinical Trial to Compare the Efficacy and Safety of a New Monophasic Hyaluronic Acid Filler and Biphasic Filler in Correcting Nasolabial Fold

2021 ◽  
Author(s):  
Michael A. C. Kane
Keyword(s):  
Clinical Trial ◽  
Hyaluronic Acid ◽  
Nasolabial Fold ◽  
Efficacy And Safety ◽  
Single Center ◽  
Double Blind ◽  
Double Blind Clinical Trial

scholarly journals Failure rates for stainless steel versus titanium alloy infrazygomatic crest bone screws: A single-center, randomized double-blind clinical trial

2018 ◽  
Vol 89 (1) ◽  
pp. 40-46 ◽  
Author(s):  
Chris H. Chang ◽  
Joshua S. Lin ◽  
W. Eugene Roberts
Keyword(s):  
Clinical Trial ◽  
Stainless Steel ◽  
Titanium Alloy ◽  
Bone Screws ◽  
Failure Rates ◽  
Single Center ◽  
Double Blind ◽  
Double Blind Clinical Trial ◽  
Attached Gingiva ◽  
Bimaxillary Protrusion

ABSTRACT Objectives: To compare failure rates for stainless steel (SS) and titanium alloy (TiA) bone screws (BSs) placed in the infrazygomatic crest (IZC). Materials and Methods: A total of 386 consecutive patients (76 male, 310 female; mean age 24.3 years, range 10.3–59.4 years) received IZC BSs (SS or TiA) via a double-blind, split-mouth design. BSs penetrated attached gingiva (AG) or moveable mucosa (MM) with 5 mm of soft tissue clearance. All BSs were immediately loaded and reactivated monthly with ≤14 oz (397 g or 389 cN) applied directly to the upper archwire bilaterally for 6 months to retract the maxilla to correct Class II or bimaxillary protrusion. Results: Of the 772 devices, there were 49 (6.3%) failures: 27 SS (7.0%) and 22 TiA (5.7%). The 1.3% difference was not statistically significant (P = .07). There was no significant relationship between SS or TiA failures relative to (1) right vs left side, (2) unilateral vs bilateral, or (3) age at failure. Significantly (P < .05) increased failure rates were noted for SS screws in only two subgroups: AG site (7.4%) and right side (7.8%). Unilateral failure occurred in 21 patients (5.4%), and bilateral failures occurred in 14 of the total 772 patients (1.8%). Conclusions: The overall success rate of 93.7% indicates that both SS and TiA are clinically acceptable for IZC BSs.

scholarly journals Knee joint space width progression: results of a 3.3 years randomized, double blind clinical trial with hyaluronic acid. The AMELIA project

2012 ◽  
Vol 20 ◽  
pp. S168-S169
Author(s):  
F. Navarro-Sarabia ◽  
F.J. Toyos ◽  
G. Herrero-Beaumont ◽  
P. Coronel ◽  
M. Gimeno ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Hyaluronic Acid ◽  
Knee Joint ◽  
Joint Space Width ◽  
Joint Space ◽  
Double Blind ◽  
Double Blind Clinical Trial ◽  
Space Width
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