Prediction of human pharmacokinetics and tissue distribution of apicidin, a potent histone deacetylase inhibitor, by physiologically based pharmacokinetic modeling

Human Pharmacokinetics ◽

Deacetylase Inhibitor ◽

Physiologically Based Pharmacokinetic Modeling and Tissue Distribution Characteristics of SHetA2 in Tumor-Bearing Mice

The AAPS Journal ◽

10.1208/s12248-020-0421-z ◽

2020 ◽

Vol 22 (2) ◽

Author(s):

Ankur Sharma ◽

Mengjie Li ◽

Elangovan Thavathiru ◽

Mariam Ibrahim ◽

Lucila Garcia-Contreras ◽

...

Keyword(s):

Tissue Distribution ◽

Distribution Characteristics ◽

Tumor Bearing ◽

Steady-State Human Pharmacokinetics of Monobutyl Phthalate Predicted by Physiologically Based Pharmacokinetic Modeling Using Single-Dose Data from Humanized-Liver Mice Orally Administered with Dibutyl Phthalate

Chemical Research in Toxicology ◽

10.1021/acs.chemrestox.8b00361 ◽

2019 ◽

Vol 32 (2) ◽

pp. 333-340 ◽

Cited By ~ 6

Author(s):

Tomonori Miura ◽

Shotaro Uehara ◽

Sawa Mizuno ◽

Manae Yoshizawa ◽

Norie Murayama ◽

...

Keyword(s):

Single Dose ◽

Steady State ◽

Dibutyl Phthalate ◽

Human Pharmacokinetics ◽

Physiologically Based ◽

Monobutyl Phthalate

Rodgers T, Rowland M. 2006. Physiologically‐based Pharmacokinetic Modeling 2: Predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci 95:1238–1257.

10.1002/jps.20857 ◽

2007 ◽

Vol 96 (11) ◽

pp. 3153-3154 ◽

Cited By ~ 5

Author(s):

Trudy Rodgers ◽

Malcolm Rowland

Keyword(s):

Tissue Distribution ◽

Weak Bases ◽

PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration–time profiles in human by using the physiologically‐based pharmacokinetic modeling approach

10.1002/jps.22550 ◽

2011 ◽

Vol 100 (10) ◽

pp. 4127-4157 ◽

Cited By ~ 115

Author(s):

Patrick Poulin ◽

Rhys D.O. Jones ◽

Hannah M. Jones ◽

Christopher R. Gibson ◽

Malcolm Rowland ◽

...

Keyword(s):

Plasma Concentration ◽

Predictive Models ◽

Human Pharmacokinetics ◽

Time Profiles ◽

Modeling Approach ◽

Concentration Time ◽

Predicting Human Pharmacokinetics: Physiologically Based Pharmacokinetic Modeling and In Silico ADME Prediction in Early Drug Discovery

European Journal of Drug Metabolism and Pharmacokinetics ◽

10.1007/s13318-018-0503-9 ◽

2018 ◽

Vol 44 (1) ◽

pp. 135-137 ◽

Cited By ~ 2

Author(s):

Jian Shi ◽

Weibin Zha

Keyword(s):

Drug Discovery ◽

In Silico ◽

Human Pharmacokinetics ◽

Adme Prediction ◽

Physiologically Based ◽

In Silico Adme Prediction ◽

Early Drug

Whole-Body Physiologically Based Pharmacokinetic Modeling of Trastuzumab and Prediction of Human Pharmacokinetics

10.1016/j.xphs.2019.01.024 ◽

2019 ◽

Vol 108 (6) ◽

pp. 2180-2190 ◽

Cited By ~ 1

Author(s):

Dong-Jun Bae ◽

Sang-Yeob Kim ◽

Sang Mun Bae ◽

Ae-Kyung Hwang ◽

Kwan Cheol Pak ◽

...

Keyword(s):

Whole Body ◽

Human Pharmacokinetics ◽

Estimation of placental and lactational transfer and tissue distribution of atrazine and its main metabolites in rodent dams, fetuses, and neonates with physiologically based pharmacokinetic modeling

Toxicology and Applied Pharmacology ◽

10.1016/j.taap.2013.08.010 ◽

2013 ◽

Vol 273 (1) ◽

pp. 140-158 ◽

Cited By ~ 34

Author(s):

Zhoumeng Lin ◽

Jeffrey W. Fisher ◽

Ran Wang ◽

Matthew K. Ross ◽

Nikolay M. Filipov

Keyword(s):

Tissue Distribution ◽

Physiologically Based ◽

Lactational Transfer

Interspecies prediction of pharmacokinetics and tissue distribution of doxorubicin by physiologically‐based pharmacokinetic modeling

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.2229 ◽

2020 ◽

Vol 41 (4-5) ◽

pp. 192-205

Author(s):

Jong Bong Lee ◽

Simon Zhou ◽

Manting Chiang ◽

Xiaowei Zang ◽

Tae Hwan Kim ◽

...

Keyword(s):

Tissue Distribution ◽

Rodgers T, Leahy D, Rowland M. 2005. Physiologically based pharmacokinetic modeling 1: Predicting the tissue distribution of moderate‐to‐strong bases. J Pharm Sci 94:1259–1276.

10.1002/jps.20856 ◽

2007 ◽

Vol 96 (11) ◽

pp. 3151-3152 ◽

Cited By ~ 5

Author(s):

Trudy Rodgers ◽

David Leahy ◽

Malcolm Rowland

Keyword(s):

Tissue Distribution ◽

Physiologically Based Pharmacokinetic Modeling 1: Predicting the Tissue Distribution of Moderate-to-Strong Bases

10.1002/jps.20322 ◽

2005 ◽

Vol 94 (6) ◽

pp. 1259-1276 ◽

Cited By ~ 428

Author(s):

Trudy Rodgers ◽

David Leahy ◽

Malcolm Rowland

Keyword(s):

Tissue Distribution ◽