Evaluation and comparison of cartilage repair tissue of the patella and medial femoral condyle by using morphological MRI and biochemical zonal T2 mapping

2008 ◽  
Vol 19 (5) ◽  
pp. 1253-1262 ◽  
Author(s):  
Goetz H. Welsch ◽  
Tallal C. Mamisch ◽  
Sebastian Quirbach ◽  
Lukas Zak ◽  
Stefan Marlovits ◽  
...  
Keyword(s):  
Cartilage Repair ◽  
T2 Mapping ◽  
Femoral Condyle ◽  
Medial Femoral Condyle ◽  
Repair Tissue

scholarly journals Juvenile Osteochondritis Dissecans: Cartilage T2 Mapping of Stable Medial Femoral Condyle Lesions

Radiology ◽  
2018 ◽  
Vol 288 (2) ◽  
pp. 536-543 ◽  
Author(s):  
Jie C. Nguyen ◽  
Fang Liu ◽  
Donna G. Blankenbaker ◽  
Kaitlin M. Woo ◽  
Richard Kijowski
Keyword(s):  
Osteochondritis Dissecans ◽  
T2 Mapping ◽  
Femoral Condyle ◽  
Medial Femoral Condyle ◽  
Juvenile Osteochondritis Dissecans

First-in-Human Pilot Study of Implantation of a Scaffold-Free Tissue-Engineered Construct Generated From Autologous Synovial Mesenchymal Stem Cells for Repair of Knee Chondral Lesions

2018 ◽  
Vol 46 (10) ◽  
pp. 2384-2393 ◽  
Author(s):  
Kazunori Shimomura ◽  
Yukihiko Yasui ◽  
Kota Koizumi ◽  
Ryota Chijimatsu ◽  
David A. Hart ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Magnetic Resonance ◽  
Cartilage Repair ◽  
Femoral Condyle ◽  
Chondral Lesions ◽  
Repair Tissue ◽  
Biopsy Specimens ◽  
Implantation Procedure

Background: Articular cartilage has limited healing capacity, owing in part to poor vascularity and innervation. Once injured, it cannot be repaired, typically leading to high risk for developing osteoarthritis. Thus, cell-based and/or tissue-engineered approaches have been investigated; however, no approach has yet achieved safety and regenerative repair capacity via a simple implantation procedure. Purpose: To assess the safety and efficacy of using a scaffold-free tissue-engineered construct (TEC) derived from autologous synovial membrane mesenchymal stem cells (MSCs) for effective cartilage repair. Study Design: Case series; Level of evidence, 4. Methods: Five patients with symptomatic knee chondral lesions (1.5-3.0 cm2) on the medial femoral condyle, lateral femoral condyle, or femoral groove were included. Synovial MSCs were isolated from arthroscopic biopsy specimens and cultured to develop a TEC that matched the lesion size. The TECs were then implanted into chondral defects without fixation and assessed up to 24 months postoperatively. The primary outcome was the safety of the procedure. Secondary outcomes were self-assessed clinical scores, arthroscopy, tissue biopsy, and magnetic resonance image–based estimation of morphologic and compositional quality of the repair tissue. Results: No adverse events were recorded, and self-assessed clinical scores for pain, symptoms, activities of daily living, sports activity, and quality of life were significantly improved at 24 months after surgery. Secure defect filling was confirmed by second-look arthroscopy and magnetic resonance imaging in all cases. Histology of biopsy specimens indicated repair tissue approaching the composition and structure of hyaline cartilage. Conclusion: Autologous scaffold-free TEC derived from synovial MSCs may be used for regenerative cartilage repair via a sutureless and simple implantation procedure. Registration: 000008266 (UMIN Clinical Trials Registry number).

scholarly journals Current Practice of Analysis and Treatment of underlying Varus Deformity in Patients with Cartilage Defects of the medial Femoral Condyle: Data of the German Cartilage Registry (KnorpelRegister DGOU)

2019 ◽  
Vol 7 (6_suppl4) ◽  
pp. 2325967119S0023
Author(s):  
Svea Faber ◽  
Johannes Zellner ◽  
Alfred Hochrein ◽  
Gunter Spahn ◽  
Philipp Niemeyer
Keyword(s):  
Cartilage Repair ◽  
Femoral Condyle ◽  
Weight Bearing ◽  
Combined Treatment ◽  
Varus Deformity ◽  
Outcome Evaluation ◽  
Medial Femoral Condyle ◽  
Tibial Osteotomy ◽  
Leg Axis ◽  
Preoperative Analysis

Aims and Objectives: In the context of cartilage repair, identification of the underlying pathologies depends on detailed preoperative evaluation. High tibial osteotomy (HTO) for varus deformities is one of the most common concomitant treatments, though scientific evidence about efficiency of concomitant HTO is still limited. The present study was initiated to describe preoperative analysis of alignment and to analysis outcome comparing patients with combined cartilage repair and HTO with those who received cartilage repair procedures alone. Materials and Methods: The multicenter data (3855 data sets on April 15, 2018) was provided by the attending physician and a self-reported outcome analysis (KOOS). Inclusion criteria: Existence of a leg full length portrait, a single defect at the medial femoral condyle, either no accompanying surgery or a HTO and information on leg axis misalignment. For outcome evaluation patients were divided into three different groups with regard to the extent of varus deformity: MILD (0-4° varus), MODERATE (5-9° varus) and SEVERE (> 10°). Statistical Analysis was performed using SPSS (IBM) Version 23. For detection of significances between different groups one-way ANOVA test was applied. P-values < 0.05 were considered statistical significant. Results: In 55.1% (n=2125) of the patients a full leg weight-bearing radiographs has been performed preoperatively. Out of these 834 (39%) cases with isolated defects of the medial femoral condyle have been identified of which 179 received HTO in combination with the cartilage repair procedure (21.5%), while 411 cases have been treated with isolated cartilage repair (49.3%). From the remaining 385 patients, 256 patients were considered MILD (67,3%), 113 MODERATE (29.5%) and 4.2% (n=16) SEVERE. Incidence of HTO significantly depended on the degree of varus deformity for mild (19% HTO) and moderate (83% HTO) deformity, but there was no significance between the moderate and severe (81% HTO) group. Significant differences of the KOOS score could be shown preoperatively between the mild (mean: 57.3), as well as moderate (mean: 55.95), and the severe group (mean 39.53) and six months postoperatively between the mild (mean: 71.48) and the severe (mean: 52.6) group. Conclusion: The present analysis of a large patients cohort extracted from the German Cartilage Registry (KnorpelRegister DGOU) demonstrates that, against common guidelines, full-leg weigth-bearing radiographs are not conducted on a regular basis in patients assigned for cartilage repair procedures. In those cases with detailed preoperative analysis of alignment, the degree of deformity seems to influence the decision, whether a realignment procedure (HTO) is performed. For the moderate subgroup a trend towards better clinical outcome was found for combined treatment in terms of realignment and cartilage repair in comparison to cartilage repair alone. Since there was no difference in the MILD subgroup, more evidence is needed to proof, whether those patients benefit from a HTO or not.

Evaluation of cartilage repair tissue after biomaterial implantation in rat patella by using T2 mapping

2004 ◽  
Vol 17 (3-6) ◽  
pp. 219-228 ◽  
Author(s):  
A. Watrin-Pinzano ◽  
J.-P. Ruaud ◽  
Y. Cheli ◽  
P. Gonord ◽  
L. Grossin ◽  
...  
Keyword(s):  
Cartilage Repair ◽  
T2 Mapping ◽  
Repair Tissue

Magnetization transfer contrast and T2 mapping in the evaluation of cartilage repair tissue with 3T MRI

2008 ◽  
Vol 28 (4) ◽  
pp. 979-986 ◽  
Author(s):  
Goetz H. Welsch ◽  
Siegfried Trattnig ◽  
Klaus Scheffler ◽  
Pavol Szomonanyi ◽  
Sebastian Quirbach ◽  
...  
Keyword(s):  
Cartilage Repair ◽  
Magnetization Transfer ◽  
T2 Mapping ◽  
Magnetization Transfer Contrast ◽  
3T Mri ◽  
Repair Tissue

Longitudinal evaluation of cartilage repair tissue after microfracture using T2-mapping: a case report with arthroscopic and MRI correlation

2010 ◽  
Vol 18 (11) ◽  
pp. 1545-1550 ◽  
Author(s):  
José M. Mejía Oneto ◽  
Jutta Ellermann ◽  
Robert F. LaPrade
Keyword(s):  
Case Report ◽  
Cartilage Repair ◽  
T2 Mapping ◽  
Longitudinal Evaluation ◽  
Repair Tissue

Comparison of Clinical Outcome following Cartilage Repair for Patients with Underlying Varus Deformity with or without Additional High Tibial Osteotomy: A Propensity Score–Matched Study Based on the German Cartilage Registry (KnorpelRegister DGOU)

Cartilage ◽  
2020 ◽  
pp. 194760352098234
Author(s):  
Svea Faber ◽  
Peter Angele ◽  
Johannes Zellner ◽  
Gerrit Bode ◽  
Alfred Hochrein ◽  
...  
Keyword(s):  
Propensity Score ◽  
High Tibial Osteotomy ◽  
Cartilage Repair ◽  
Femoral Condyle ◽  
Varus Deformity ◽  
Medial Femoral Condyle ◽  
Cartilage Defects ◽  
Tibial Osteotomy ◽  
Matched Study

Background Even though realignment procedures have gained popularity as concomitant techniques in cartilage repair approaches with underlying malalignment, the clinical efficacy has not been proven to full extent. Methods Out of 5474 patients from the German Cartilage Registry, 788 patients with focal cartilage defects on the medial femoral condyle having received either no accompanying surgery or high tibial osteotomy (HTO) were identified. After a 1:1 propensity score matching, outcome of 440 patients was evaluated using KOOS (Knee Injury and Osteoarthritis Outcome Score), VAS (visual analogue scale), and satisfaction during the 3-year follow-up. Results Patients having received a concomitant HTO had significantly higher postoperative KOOS values (12 months: 67.26 ± 15.69 vs.75.10 ± 16.12, P = 0.001; 24 months: 67.14 ± 23.85 vs. 77.11 ± 16.50, P = 0.010; 36 months: 74.40 ± 16.57 vs. 81.75 ± 14.22, P = 0.023) and lower pain levels (6 months: 3.43 ± 2.18 vs. 2.89 ± 2.15, P = 0.009; 12 months: 3.64 ± 2.20 vs. 2.17 ± 1.96, P < 0.001; 24 months: 4.20 ± 3.12 vs. 2.94 ± 2.45, P = 0.005; 36 months: 3.20 ± 2.18 vs. 2.02 ± 1.98, P = 0.003). One and 3 years postoperatively, concomitant HTO led to significantly higher satisfaction in patients. These advantages of accompanying HTO were also seen in the group of patients with a varus deformity of 5° or more, in which pain levels without concomitant HTO even increased during the 3-year follow-up. Conclusion The results of the present study underline the importance and safety of concomitant HTO in patients with cartilage defects and varus deformity. HTO should therefore be considered and recommended generously in patients with focal cartilage defects of the medial femoral condyle and varus deformity.

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