Diffusion-weighted imaging of breast lesions: Region-of-interest placement and different ADC parameters influence apparent diffusion coefficient values

2016 ◽  
Vol 27 (5) ◽  
pp. 1883-1892 ◽  
Author(s):  
Hubert Bickel ◽  
Katja Pinker ◽  
Stephan Polanec ◽  
Heinrich Magometschnigg ◽  
Georg Wengert ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Diffusion Weighted Imaging ◽  
Region Of Interest ◽  
Breast Lesions ◽  
Diffusion Weighted ◽  
Apparent Diffusion Coefficient Values ◽  
Apparent Diffusion

Effects of contrast-enhancement on diffusion weighted imaging and apparent diffusion coefficient measurements in 3-T magnetic resonance imaging of breast lesions

2017 ◽  
Vol 59 (8) ◽  
pp. 902-908
Author(s):  
Valentina Cipolla ◽  
Daniele Guerrieri ◽  
Giacomo Bonito ◽  
Simone Celsa ◽  
Carlo de Felice
Keyword(s):  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Diffusion Weighted Imaging ◽  
Breast Lesions ◽  
Post Contrast ◽  
Diffusion Weighted ◽  
Signed Rank ◽  
Apparent Diffusion ◽  
Malignant Breast ◽  
Adc Values

Background The effect of gadolinium-based contrast agents on diffusion-weighted imaging (DWI) measurements of breast lesions is still not clear. Purpose To investigate gadolinium effects on DWI and apparent diffusion coefficient (ADC) in breast lesions and normal parenchyma with 3 Tesla contrast-enhanced MRI. Material and Methods Pre- and post-contrast DWI (b = 0 and b = 1000 s/mm2) were acquired in 47 patients. Measured ADC values, pre- and post-contrast T2 signal intensity (T2 SI) and contrast-to-noise ratio (CNR) were compared with Wilcoxon signed-rank and rank-sum test ( P < 0.05). Results Post-contrast ADC was reduced only in malignant lesions (−34%), T2 SI was reduced both in malignant (−50%) and benign (−36%) lesions. Post-contrast CNR was reduced in all groups except for benign lesions. Conclusion Gadolinium-based contrast agent causes a significant reduction in ADC values of malignant breast lesions.

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