Surgical method influences specimen margins and biochemical recurrence during radical prostatectomy for high-risk prostate cancer: a systematic review and meta-analysis

2017 ◽  
Vol 35 (10) ◽  
pp. 1481-1488 ◽  
Author(s):  
Victor Srougi ◽  
Jose Bessa ◽  
Mohammed Baghdadi ◽  
Igor Nunes-Silva ◽  
Jose Batista da Costa ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Systematic Review ◽  
High Risk ◽  
Radical Prostatectomy ◽  
Biochemical Recurrence ◽  
Meta Analysis ◽  
Surgical Method ◽  
High Risk Prostate Cancer ◽  
Risk Prostate Cancer

A systematic review and meta-analysis to evaluate the influence of surgical method on specimen margins and biochemical recurrence after radical prostatectomy for high-risk prostate cancer.

2017 ◽  
Vol 35 (6_suppl) ◽  
pp. 65-65
Author(s):  
Victor Srougi ◽  
Jose Bessa ◽  
Mohammed Baghdadi ◽  
Igor Nunes-Silva ◽  
Silvia Garcia Barreras ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Systematic Review ◽  
High Risk ◽  
Radical Prostatectomy ◽  
Biochemical Recurrence ◽  
Meta Analysis ◽  
Risk Difference ◽  
High Risk Prostate Cancer ◽  
Strong Conclusion ◽  
Risk Prostate Cancer

65 Background: To date there is no robust evidence comparing the outcomes of robotic and open radical prostatectomies in patients with high-risk prostate cancer. The purpose of this study is to perform a meta-analysis comparing the rates of positive surgical margins (PSM) and biochemical recurrence (BCR) between open radical prostatectomy (ORP) and robot-assisted radical prostatectomy (RARP) in patients with high-risk prostate cancer. Methods: A systematic review was performed on Pubmed, Embase and Scopus databases in August 2016, according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement. References retrieved were evaluated using the Newcastle-Ottawa scale and the Black and Down’s tool for quality assessment. Nine retrospective cohorts comparing ORP and RARP were selected and included in the meta-analysis. Results: Nine studies reported the PSMs. Patients treated with RARP presented less risk of PSMs (risk difference -0.04, p 0.02) than those treated with ORP. Five articles reported hazard ratios for BCR-free survival. Patients treated with RARP had less risk of BCR (HR 0.72, 95% CI 0.58-0.89) than those treated with ORP. Reports for PSM assessment were considered of adequate quality, while the studies retrieved for BCR assessment were considered limited because of the heterogeneity of their results. Conclusions: Patients with high-risk prostate cancer treated with RARP have less risk of having PSM and BCR when compared to those treated with ORP. A strong conclusion is precluded due to the observational nature of the studies retrieved for our analysis.

Radical prostatectomy for locally advanced and high-risk prostate cancer: A systematic review of the literature

2018 ◽  
Vol 28 (16) ◽  
pp. 875-889 ◽  
Author(s):  
G. Delporte ◽  
F. Henon ◽  
G. Ploussard ◽  
A. Briganti ◽  
J. Rizk ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Systematic Review ◽  
High Risk ◽  
Radical Prostatectomy ◽  
Locally Advanced ◽  
Review Of The Literature ◽  
High Risk Prostate Cancer ◽  
Risk Prostate Cancer

Predictive factors of biochemical recurrence after radical prostatectomy for high-risk prostate cancer

2018 ◽  
Vol 25 (3) ◽  
pp. 284-289 ◽  
Author(s):  
Yukiko Murata ◽  
Katsunori Tatsugami ◽  
Masahiro Yoshikawa ◽  
Masumitsu Hamaguchi ◽  
Shigetomo Yamada ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Radical Prostatectomy ◽  
Predictive Factors ◽  
Biochemical Recurrence ◽  
High Risk Prostate Cancer ◽  
Risk Prostate Cancer

PSA-recurrence after radical prostatectomy for intermediate/high risk prostate cancer: A helpful parameter or just a patient stress amplifier.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e16535-e16535
Author(s):  
Martin Spahn ◽  
Marianna Kruithof-de Julio ◽  
Silvan Boxler ◽  
Marc-Alain Furrer ◽  
George N. Thalmann ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
High Risk ◽  
Radical Prostatectomy ◽  
Biochemical Recurrence ◽  
Clinical Failure ◽  
High Risk Prostate Cancer ◽  
Risk Prostate Cancer ◽  
Psa Recurrence ◽  
Time Point

e16535 Background: Development of biochemical recurrence with a rising PSA level after radical prostatectomy causes significant anxiety for patients and treating oncologist. Management of these patients is controversial. Here, we characterize the natural course and pattern of disease progression and survival in men with biochemical recurrence (BCR) after radical prostatectomy (RP) for intermediate and high-risk prostate cancer (PCa) untreated until clinical failure (CF). Methods: Retrospective analysis of consecutive men with BCR after RP for intermediate/high risk PCa. All patients underwent RP+extended pelvic lymph node dissection. A PSA level > 0.2 ng/ml on two consecutive measures was considered BCR. None received neoadjuvant or adjuvant therapy prior to documented clinical failure by body imaging, which was performed at the time point of BCR or symptoms and at least once per year. Results: Of the 622 men with BCR included into the analysis, 267 (43%) had high risk PCa. Median follow-up after RP was 9.4 yrs. (IQR 4.8-15.1) and median time from RP to BCR was 1.4 yrs. (IQR 0.4-3.6). Of the patients 324 (52%) never experienced CF (Æfollow-up from BCR 5.8yr, IQR2.1-11.9); 88 (14%) had local recurrence only; 59 (9%) had lymph node metastasis +/-local recurrence and 151(24%) distant metastasis. The median times from BCR to CF were: 9.5 yrs. (IQR 5.6-13.5) for local failure; 4.9 yrs. (IQR 3.1-8.8) for lymph node failure and 5.6 yrs. (IQR 3-10.5) for distant failure. The 10-yrs cancer specific (CSS) and overall survival (OS) of the entire group from time point of BCR was 78% and 66%, respectively. 5- and 7-yrs conditional CSS from time of CF was strongly depended on recurrence pattern and ranged from 90% and 79% (local only) to 70% and 47% (lymph node+/-local) and 47% and 36% (distant mets), respectively. PSA-doubling time < 12 months and > 2 positive nodes were independent predictors of outcome in multivariate analysis. Conclusions: These data may be useful in informing men with intermediate/high risk PCa regarding the natural course of PSA recurrence and counseling the timing of additional therapies.

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