Oncological safety and functional outcomes of testosterone replacement therapy in symptomatic adult-onset hypogonadal prostate cancer patients following robot-assisted radical prostatectomy

2020 ◽  
Author(s):  
Hanna Shahine ◽  
Marc Zanaty ◽  
Ahmed S. Zakaria ◽  
David-Dan Nguyen ◽  
Felix Couture ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Replacement Therapy ◽  
Cancer Patients ◽  
Functional Outcomes ◽  
Testosterone Replacement ◽  
Testosterone Replacement Therapy ◽  
Adult Onset ◽  
Robot Assisted ◽  
Oncological Safety

scholarly journals Testosterone Replacement Therapy in Patients with Prostate Cancer After Radical Prostatectomy

2013 ◽  
Vol 190 (2) ◽  
pp. 639-644 ◽  
Author(s):  
Alexander W. Pastuszak ◽  
Amy M. Pearlman ◽  
Win Shun Lai ◽  
Guilherme Godoy ◽  
Kumaran Sathyamoorthy ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Replacement Therapy ◽  
Testosterone Replacement ◽  
Testosterone Replacement Therapy

scholarly journals A survey of Canadian urologists’ opinions and prescribing patterns of testosterone replacement therapy in men on active surveillance for low-risk prostate cancer

2016 ◽  
Vol 10 (5-6) ◽  
pp. 181 ◽  
Author(s):  
Adam C. Millar ◽  
Dean S. Elterman ◽  
Larry Goldenberg ◽  
Brandon Van Asseldonk ◽  
Ashley Curtis ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Replacement Therapy ◽  
Active Surveillance ◽  
Low Risk ◽  
Testosterone Replacement ◽  
External Beam Radiation ◽  
Testosterone Replacement Therapy ◽  
Low Grade ◽  
Testosterone Deficiency

Introduction: Attitudes regarding the safety of testosterone replacement therapy (TRT) in hypogonadal men with prostate cancer (PCa) have changed over the past few years with the emergence of case studies suggesting a low risk of cancer progression and a better understanding of the interaction of different levels of androgen with prostate cellular metabolism. This new view has the potential to change clinical practice.Methods: Active members of the Canadian Urological Association were surveyed about their opinions on the safety of TRT in men with low-risk PCa, as well as their current prescribing habits.Results: Of 57 responding urologists, 86% actively prescribe TRT in men with testosterone deficiency syndrome (TDS), 93% are involved in the treatment of men with PCa, and 95% offer active surveillance as a management option for low-grade/low-stage disease. Furthermore, 65% stated that they would offer TRT to men with TDS who were on active surveillance for PCa and 63% believed that TRT did not increase the risk of progression of PCa in these men. In terms of treatment methods, 96% believed TRT was safe for men who have undergone radical prostatectomy, while a smaller number felt it was safe for patients who have undergone brachytherapy (86%) or external beam radiation (84%). Despite these figures, only 35% of the surveyed physicians had ever offered TRT for men on active surveillance and only 42% actually had men in their practice who were taking testosterone while on active surveillance.Conclusions: The discrepancy between urologists’ beliefs about the safety of TRT and their clinical practice patterns may be due to multiple factors, such as hesitation in recommending treatment in real-life practice, low numbers of eligible patients, absence of screening for testosterone deficiency in patients on active surveillance, and patient preference or fears. Furthermore, the difference in perceived safety in men treated by radical prostatectomy vs. radiation therapy suggests that some urologists are concerned that the radiated gland remaining in-situ may be “reactivated” by TRT. The results from this survey will be used as the basis of developing a national Canadian registry of men with low-grade/stage PCa who are receiving TRT while on active surveillance.

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