A young adult with coronary artery and jugular vein thrombosis: a case report of combined protein S and protein C deficiency

2002 ◽  
Vol 17 (2) ◽  
pp. 74-76 ◽  
Author(s):  
Ö. Çakır ◽  
Orhan Ayyıldız ◽  
Ahmet Oruc ◽  
Nesimi Eren
2008 ◽  
Vol 5 (3) ◽  
pp. 169-173
Author(s):  
Ioannis Starakis ◽  
Dimitrios Siagris ◽  
Eftichia Polyzogopoulou ◽  
Elias Mazokopakis

Blood ◽  
1995 ◽  
Vol 85 (10) ◽  
pp. 2756-2761 ◽  
Author(s):  
T Koster ◽  
FR Rosendaal ◽  
E Briet ◽  
FJ van der Meer ◽  
LP Colly ◽  
...  

A deficiency of protein C (PC), antithrombin, or protein S is strongly associated with deep-vein thrombosis in selected patients and their families. However, the strength of the association with venous thrombosis in the general population is unknown. This study was a population-based, patient-control study of 474 consecutive outpatients, aged less than 70 years, with a first, objectively diagnosed, episode of venous thrombosis and without an underlying malignant disease, and 474 healthy controls who matched for age and sex. Relative risks were estimated as matched odds ratios. Based on a single measurement, there were 22 (4.6%) patients with a PC deficiency (PC activity, less than 0.67 U/mL or PC antigen, less than 0.33 U/mL when using coumarins). Among the controls, the frequency was 1.5% (seven subjects). Thus, there is a threefold increase in risk of thrombosis in subjects with PC levels below 0.67 or 0.33 U/mL [matched odds ratio, 3.1; 95% confidence interval (CI), 1.4 to 7.0]. When a PC deficiency was based on two repeated measurements, the relative risk for thrombosis increased to 3.8 (95% CI, 1.3 to 10); when it was based on DNA-confirmation, the relative risk increased further to 6.5 (95% CI, 1.8 to 24). In addition, there was a gradient in thrombosis risk, according to PC levels. The results for antithrombin are similar to those for PC, although less pronounced (relative risk, 2.2; 95% CI, 1.0 to 4.7). We could not find an association between reduced total protein S (relative risk, 0.7; 95% CI, 0.3 to 1.8) or free protein S levels (relative risk, 1.6; 95% CI, 0.6 to 4.0) and thrombosis risk. Although not very frequent, PC and antithrombin deficiency are clearly associated with an increase in thrombosis risk.


Neurosurgery ◽  
1997 ◽  
Vol 41 (3) ◽  
pp. 680-683 ◽  
Author(s):  
Bryan J. Duke ◽  
Robert K. Ryu ◽  
Kerry E. Brega ◽  
Douglas M. Coldwell

2000 ◽  
Vol 114 (7) ◽  
pp. 545-547 ◽  
Author(s):  
R. Agarwal ◽  
P. S. Arunachalam ◽  
D. A. Bosman

Lemierre’s syndrome is a recognized but infrequently seen complication of acute oropharyngitis. In this case report the patient presented with acute sore throat that led to a bacteraemia with internal jugular vein thrombosis and subsequent cranial nerve palsies.


2008 ◽  
Vol 19 (6) ◽  
pp. 601-604 ◽  
Author(s):  
Fu-Chi Yang ◽  
Chang-Hung Hsu ◽  
Jiann-Chyun Lin ◽  
Cheng-Yu Chen ◽  
Jiunn-Tay Lee

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