The safety and efficacy of stapled hemorrhoidectomy in the treatment of hemorrhoids: a systematic review and meta-analysis of ten randomized control trials

2005 ◽  
Vol 21 (2) ◽  
pp. 172-178 ◽  
Author(s):  
Ping Lan ◽  
Xjiaojian Wu ◽  
Xuyu Zhou ◽  
Jianping Wang ◽  
Longjuan Zhang
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Randomized Control Trials ◽  
Stapled Hemorrhoidectomy ◽  
Safety And Efficacy ◽  
Randomized Control

scholarly journals “Safety and efficacy of pharmacotherapy used for the management of COVID 19: A systematic review and meta-analysis of randomized control trials”

2020 ◽  
Author(s):  
Sujit Kumar Sah ◽  
Krishna Undela ◽  
Sharad Chand ◽  
Madhan Ramesh ◽  
R Subramanian ◽  
...  
Keyword(s):  
Systematic Review ◽  
Statistical Analysis ◽  
Meta Analysis ◽  
Ordinal Scale ◽  
Cochrane Library ◽  
P Value ◽  
Randomized Control Trials ◽  
Pharmacological Management ◽  
Safety And Efficacy ◽  
Randomized Control

AbstractBackgroundCOVID-19 is a novel coronavirus, which is highly contagious and a threat to human health, spreading across nearly 235 countries, affecting 33.8 million and causing 1.01 million fatalities as of 22 September 2020. Researchers have invested tremendous efforts to develop vaccines or effective drug therapy but have not yet been fruitful. Hence, we planned to conduct this systematic review and meta-analysis to supplement the readers with comprehensive data and credible information on the safety and efficacyof essential pharmacotherapy during the pharmacological management of COVID-19.MethodsTheprotocol will be designed based on the updated PRISMA-P 2015 guidelines. An elaborate search of electronic databases such as PubMed/Medline, Web of Science, Scopus, The Cochrane Library, ClinicalTrials.gov, Google Scholar, Medrxiv and other potential databases for articles published during January 2020 to 10 October 2020 is planned to be conducted. Following this,randomized control trials published in English language that assess the safety and efficacy of pharmacotherapy versusplacebo or standard of care or usual care will be evaluated for inclusion. The primary outcomes will include time to clinical recovery and the probability for the negative conversion of COVID-19. Secondary outcomes will quantifythe proportion of patients relieved of symptoms, the all-cause mortality, morbidity, detection of viral RNA, time needed to achieve a negative viral load, ordinal scale changes, ventilatorand oxygen requirements,length of hospital stayand the incidence of adverse and serious adverse events.RevMan V.5.3 computer software packages will be utilised to conduct an accurate statistical analysis of the study. Thebinary random-effects model will be used at a 95 % confidence interval to estimate the weighted effect size ofdichotomous data and continuous data studies. The results of statistical analysis will be considered statistically significant whena p-value <0.05 is attained.ResultsSelected studies will be used to evaluate the safety and efficacy of pharmacotherapy used during the management of the novel COVID-19.ConclusionThis study will be a qualitative and quantitative pool of comprehensive evidence regarding the safety and efficacy of pharmacotherapy on COVID-19.PROSPERO registrationCRD42020205433

Trauma-Sensitive Yoga Interventions and Posttraumatic Stress and Depression Outcomes Among Women: A Systematic Review and Analysis of Randomized Control Trials

2021 ◽  
Author(s):  
Ashleigh Kysar-Moon ◽  
Matthew Vasquez ◽  
Tierra Luppen
Keyword(s):  
Systematic Review ◽  
Posttraumatic Stress ◽  
Traumatic Event ◽  
Meta Analysis ◽  
Depression Symptoms ◽  
Randomized Control Trials ◽  
Methodological Rigor ◽  
History Of ◽  
Randomized Control ◽  
Analysis Models

Abstract Research shows that most people experience at least one traumatic event in their lifetimes, and between 6% and 8% of those with a history of trauma will develop posttraumatic stress disorder (PTSD) and/or related mental health conditions. Women face a greater threat of trauma exposure and have a higher risk of PTSD and depression than men. Trauma-Sensitive Yoga (TSY), a body-based adjunctive therapy, has shown potential in several studies as an effective method for reducing PTSD and depression symptoms. However, existing research and systematic reviews vary widely in their methodological rigor and comparison samples. Thus, in this systematic review we examined the effectiveness of TSY among women with a history of trauma and depression who had participated in randomized control trials with clear control and experimental groups. Findings in fixed- and mixed-effects meta-analysis models suggest marginally significant to no effects of TSY on PTSD and depression outcomes. Our systematic review highlights critical questions and significant gaps in the existing literature about the rationale and best practices of TSY intervention duration.

scholarly journals METFORMIN AS A PREVENTIVE AND THERAPEUTIC MODALITY IN ENDOMETRIAL CANCER: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROL TRIALS

2020 ◽  
Author(s):  
SOFIA LEKKA ◽  
Anastasia Prodromidou ◽  
Alexandros Fotiou ◽  
Victoria Psomiadou ◽  
Dimitrios Giannoulopoulos ◽  
...  
Keyword(s):  
Systematic Review ◽  
Endometrial Cancer ◽  
Meta Analysis ◽  
Therapeutic Modality ◽  
Randomized Control Trials ◽  
Randomized Control
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