Systematic review and meta-analysis of randomized controlled trials comparing botulinum toxin injection with lateral internal sphincterotomy for chronic anal fissure

2009 ◽  
Vol 24 (9) ◽  
pp. 995-1000 ◽  
Author(s):  
Wan-Jin Shao ◽  
Guo-Chun Li ◽  
Zhi-Kun Zhang
Keyword(s):  
Systematic Review ◽  
Botulinum Toxin ◽  
Randomized Controlled Trials ◽  
Anal Fissure ◽  
Chronic Anal Fissure ◽  
Meta Analysis ◽  
Botulinum Toxin Injection ◽  
Lateral Internal Sphincterotomy ◽  
Controlled Trials ◽  
Randomized Controlled

scholarly journals Efficacy and Safety of Botulinum Toxin vs. Placebo in Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2020 ◽  
Vol 11 ◽  
Author(s):  
Huan Qian ◽  
Fangjie Shao ◽  
Cameron Lenahan ◽  
Anwen Shao ◽  
Yingjun Li
Keyword(s):  
Systematic Review ◽  
Depressive Symptoms ◽  
Botulinum Toxin ◽  
Randomized Controlled Trials ◽  
Clinical Diagnosis ◽  
Effect Size ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Efficacy And Safety ◽  
Randomized Controlled

Background: Major depressive disorder (MDD) is a serious mental disorder that represents a substantial public health problem. Several trials have been undertaken to investigate the role of botulinum toxin type A (BTX-A) in the treatment of MDD, but the conclusions were controversial. To examine the efficacy and safety of BTX-A vs. placebo on patients with a clinical diagnosis of MDD, we conducted this systematic review and meta-analysis.Methods: A systematic search was conducted for all relevant randomized controlled trials (RCTs) in PubMed and Web of Science from inception to June 17, 2020. All published studies that investigated the efficacy and safety of BTX-A injections on patients with a clinical diagnosis of MDD were included. The overall effect size was summarized using a random-effects meta-analysis model. The primary outcomes of the present meta-analysis were the changes in depressive rating scale at week 6 after BTX-A injection compared with placebo. The safety of BTX-A injections also was assessed.Results: Five RCTs with a total of 417 participants (189 patients in the BTX-A group, 228 patients in placebo group) were eligible in this meta-analysis. The results indicated an overall positive effect of BTX-A injections for reducing the depressive symptoms of patients with MDD (Hedges' g, −0.82; 95% CI, −1.38 to −0.27) with large effect size. Differences are likely explained by the dose of BTX-As and the gender of the participants. Our findings also highlighted that BTX-A injections were generally well-tolerated, with only mild and temporary adverse events reported.Conclusions: The present meta-analysis provides evidence that BTX-A injections are associated with a statistically significant improvement in depressive symptoms. BTX-A injections are generally safe and may provide a new, alternative option for the treatment of depression.

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