Meta-analysis of the association between functional MICA-TM polymorphisms and systemic lupus erythematosus, rheumatoid arthritis and ankylosing spondylitis

This chapter describes the anaesthetic management of the patient with those musculoskeletal disorders which are relevant to anaesthetic practice. Topics covered include rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus (SLE); systemic sclerosis; scoliosis and achondroplasia. For each topic, pre-operative investigation and optimisation, treatment, and anaesthetic management are described.

Download Full-text

Rheumatology

Obstetric Medicine ◽

10.1093/med/9780198821540.003.0008 ◽

2020 ◽

pp. 263-306

Author(s):

Charlotte Frise ◽

Sally Collins

Keyword(s):

Rheumatoid Arthritis ◽

Systemic Lupus Erythematosus ◽

Systemic Sclerosis ◽

Psoriatic Arthritis ◽

Ankylosing Spondylitis ◽

Lupus Erythematosus ◽

Pregnant Patient ◽

Systemic Lupus ◽

Musculoskeletal Problems ◽

In Pregnancy

This chapter covers rheumatic diseases in the pregnant patient. It gives background, clinical features, and management in the pregnant patient for rheumatoid arthritis, Sjögren’s syndrome, psoriatic arthritis, systemic lupus erythematosus, antiphospholipid syndrome, and ankylosing spondylitis among others. It also covers systemic sclerosis, osteoporosis, and other musculoskeletal problems. Medications and the use of biologics in pregnancy are also discussed, with reference to breastfeeding.

Download Full-text

Bone, joint, and connective tissue disorders

10.1093/med/9780198719410.003.0009_update_001 ◽

2018 ◽

Author(s):

Colin Berry

Keyword(s):

Rheumatoid Arthritis ◽

Systemic Lupus Erythematosus ◽

Systemic Sclerosis ◽

Ankylosing Spondylitis ◽

Connective Tissue ◽

Musculoskeletal Disorders ◽

Lupus Erythematosus ◽

Anaesthetic Management ◽

Connective Tissue Disorders ◽

Systemic Lupus

This chapter describes the anaesthetic management of the patient with those musculoskeletal disorders which are relevant to anaesthetic practice. Topics covered include rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, systemic sclerosis, scoliosis, and achondroplasia. For each topic, preoperative investigation and optimization, treatment, and anaesthetic management are described.

Download Full-text

Associations between Polymorphisms in the IL-1 Gene and the Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus: Evidence from a Meta-Analysis

International Archives of Allergy and Immunology ◽

10.1159/000510641 ◽

2020 ◽

pp. 1-9

Author(s):

Lin Zhu ◽

Peng Chen ◽

Xuanjing Sun ◽

Shuo Zhang

Keyword(s):

Rheumatoid Arthritis ◽

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Web Of Science ◽

Meta Analysis ◽

Interleukin 1 ◽

Systemic Lupus

Background: Previous studies on polymorphisms in interleukin-1 (IL-1) and the risk of rheumatoid arthritis (RA)/systemic lupus erythematosus (SLE) yielded inconsistent results. Objectives: The authors performed this meta-analysis to more robustly evaluate associations between polymorphisms in the IL-1 gene and the risk of RA/SLE. Methods: MEDLINE, Embase, Web of Science, Wanfang, VIP, and CNKI were systematically searched for eligible studies, and 34 relevant studies were finally selected to be eligible for inclusion. Results: We found that IL-1A +4845G/T polymorphism was significantly associated with the risk of RA in the overall population (dominant comparison: p = 0.02; overdominant comparison: p = 0.05; allele comparison: p = 0.04), whereas IL-1B +3954C/T polymorphism was significantly associated with the risk of RA in the overall population (overdominant comparison: p = 0.03; allele comparison: p = 0.01) and Asians (recessive comparison: p = 0.007; allele comparison: p = 0.002). In addition, we found that IL-1A –889C/T polymorphism was significantly associated with the risk of SLE in Caucasians (allele comparison: p = 0.04), IL-1B –31T/C polymorphism was significantly associated with the risk of SLE in the overall population (recessive comparison: p = 0.04), and IL-1B –511C/T polymorphism was significantly associated with the risk of SLE in Asians (recessive comparison: p = 0.01; allele comparison: p = 0.03). Conclusions: This meta-analysis suggests that IL-1A +4845G/T and IL-1B +3954C/T polymorphisms may influence the risk of RA, whereas IL-1A –889C/T, IL-1B –31T/C, and IL-1B –511C/T polymorphisms may influence the risk of SLE.

Download Full-text