Contribution of Nitric Oxide in Big Endothelin-1–induced Cardioprotective Effects on Ischemia/Reperfusion Injury in Rat Hearts

2011 ◽  
Vol 57 (5) ◽  
pp. 575-578 ◽  
Author(s):  
Masashi Tawa ◽  
Taiki Fukumoto ◽  
Mamoru Ohkita ◽  
Naoto Yamashita ◽  
Ayman Geddawy ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Endothelin 1 ◽  
Rat Hearts ◽  
Cardioprotective Effects

scholarly journals Influence of Hypoxic and Hyperoxic Preconditioning on Endothelial Function in a Model of Myocardial Ischemia-Reperfusion Injury with Cardiopulmonary Bypass (Experimental Study)

2020 ◽  
Vol 21 (15) ◽  
pp. 5336
Author(s):  
Irina A. Mandel ◽  
Yuri K. Podoksenov ◽  
Irina V. Suhodolo ◽  
Darya A. An ◽  
Sergey L. Mikheev ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cardiopulmonary Bypass ◽  
Endothelial Function ◽  
Light Microscopy ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Control Group ◽  
Endothelin 1 ◽  
Nitric Oxide Metabolites

The aim of the experiment was to evaluate the effect of preconditioning based on changes in inspiratory oxygen fraction on endothelial function in the model of ischemia-reperfusion injury of the myocardium in the condition of cardiopulmonary bypass. The prospective randomized study included 32 rabbits divided into four groups: hypoxic preconditioning, hyperoxic preconditioning, hypoxic-hyperoxic preconditioning, and control group. All animals were anesthetized and mechanically ventilated. We provided preconditioning, then started cardiopulmonary bypass, followed by induced acute myocardial infarction (ischemia 45 min, reperfusion 120 min). We investigated endothelin-1, nitric oxide metabolites, asymmetric dimethylarginine during cardiopulmonary bypass: before ischemia, after ischemia, and after reperfusion. We performed light microscopy of myocardium, kidney, lungs, and gut mucosa. The endothelin-1 level was much higher in the control group than in all preconditioning groups after ischemia. The endothelin-1 even further increased after reperfusion. The total concentration of nitric oxide metabolites was significantly higher after all types of preconditioning compared with the control group. The light microscopy of the myocardium and other organs revealed a diminished damage extent in the hypoxic-hyperoxic preconditioning group as compared to the control group. Hypoxic-hyperoxic preconditioning helps to maintain the balance of nitric oxide metabolites, reduces endothelin-1 hyperproduction, and enforces organ protection.

The dual effects of nitric oxide synthase inhibitors on ischemia-reperfusion injury in rat hearts

2003 ◽  
Vol 98 (5) ◽  
pp. 319-328 ◽  
Author(s):  
Miyuki Kobara ◽  
Tetsuya Tatsumi ◽  
Mitsuo Takeda ◽  
Akiko Mano ◽  
Satoshi Yamanaka ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Nitric Oxide Synthase Inhibitors ◽  
Rat Hearts ◽  
Oxide Synthase

CARDIOPROTECTIVE EFFECTS OF QUERCETIN AGAINST ISCHEMIA-REPERFUSION INJURY IN ISOLATED JUVENILE AND ADULT RAT HEARTS

2018 ◽  
Vol 25 (3) ◽  
pp. 174
Author(s):  
Monika Bartekova ◽  
Kristina Ferenczyova ◽  
Jana Radosinska ◽  
Dezider Pancza ◽  
Miroslav Barancik ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Adult Rat ◽  
Rat Hearts ◽  
Cardioprotective Effects
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