Salvianolic Acid A Demonstrates Cardioprotective Effects in Rat Hearts and Cardiomyocytes After Ischemia/Reperfusion Injury

2011 ◽  
Vol 58 (5) ◽  
pp. 535-542 ◽  
Author(s):  
Huanjun Pan ◽  
Dongye Li ◽  
Fang Fang ◽  
Dan Chen ◽  
Lingling Qi ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Salvianolic Acid ◽  
Salvianolic Acid A ◽  
Rat Hearts ◽  
Cardioprotective Effects

Contribution of Nitric Oxide in Big Endothelin-1–induced Cardioprotective Effects on Ischemia/Reperfusion Injury in Rat Hearts

2011 ◽  
Vol 57 (5) ◽  
pp. 575-578 ◽  
Author(s):  
Masashi Tawa ◽  
Taiki Fukumoto ◽  
Mamoru Ohkita ◽  
Naoto Yamashita ◽  
Ayman Geddawy ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Endothelin 1 ◽  
Rat Hearts ◽  
Cardioprotective Effects

Salvianolic acid a attenuates limb ischemia/reperfusion injury in skeletal muscle of rats

2018 ◽  
Vol 97 ◽  
pp. 551-556 ◽  
Author(s):  
Yijia Xiang ◽  
Shiyong Ye ◽  
Changhong Cai ◽  
Junchong Chen ◽  
Xuyong Zhao ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Limb Ischemia ◽  
Salvianolic Acid ◽  
Salvianolic Acid A

CARDIOPROTECTIVE EFFECTS OF QUERCETIN AGAINST ISCHEMIA-REPERFUSION INJURY IN ISOLATED JUVENILE AND ADULT RAT HEARTS

2018 ◽  
Vol 25 (3) ◽  
pp. 174
Author(s):  
Monika Bartekova ◽  
Kristina Ferenczyova ◽  
Jana Radosinska ◽  
Dezider Pancza ◽  
Miroslav Barancik ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Adult Rat ◽  
Rat Hearts ◽  
Cardioprotective Effects

scholarly journals Cardioprotective Effects of Salvianolic Acid A on Myocardial Ischemia-Reperfusion InjuryIn VivoandIn Vitro

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Huaying Fan ◽  
Liu Yang ◽  
Fenghua Fu ◽  
Hui Xu ◽  
Qinggang Meng ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Protective Effect ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Apoptotic Cell ◽  
Ischemia Reperfusion ◽  
Salvianolic Acid ◽  
Salvianolic Acid A ◽  
Myocardial Ischemia Reperfusion Injury ◽  
Myocardial Ischemia Reperfusion

Salvianolic acid A (SAA), one of the major active components of Danshen that is a traditional Chinese medicine, has been reported to possess protective effect in cardiac diseases and antioxidative activity. This study aims to investigate the cardioprotection of SAAin vivoandin vitrousing the model of myocardial ischemia-reperfusion in rat and hydrogen peroxide (H2O2)-induced H9c2 rat cardiomyoblasts apoptosis. It was found that SAA significantly limited infarct size of ischemic myocardium when given immediately prior to reperfusion. SAA also significantly suppressed cellular injury and apoptotic cell death. Additionally, the results of western blot and phospho-specific antibody microarray analysis showed that SAA could up-regulate Bcl-2 expression and increase the phosphorylation of proteins such as Akt, p42/p44 extracellular signal-related kinases (Erk1/2), and their related effectors. The phosphorylation of those points was related to suppress apoptosis. In summary, SAA possesses marked protective effect on myocardial ischemia-reperfusion injury, which is related to its ability to reduce myocardial cell apoptosis and damage induced by oxidative stress. The protection is achieved via up-regulation of Bcl-2 expression and affecting protein phosphorylation. These findings indicate that SAA may be of value in cardioprotection during myocardial ischemia-reperfusion injury, which provide pharmacological evidence for clinical application.

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