Opposing effects on infarction of delta and kappa opioid receptor activation in the isolated rat heart: implications for ischemic preconditioning

2000 ◽  
Vol 95 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Keri A. Aitchison ◽  
Gary F. Baxter ◽  
M. Moneeb Awan ◽  
Robert M. Smith ◽  
Derek M. Yellon ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Ischemic Preconditioning ◽  
Rat Heart ◽  
Receptor Activation ◽  
Isolated Rat Heart ◽  
Kappa Opioid Receptor ◽  
Kappa Opioid ◽  
Opposing Effects ◽  
Isolated Rat

scholarly journals Kappa-opioid receptor activation during reperfusion limits myocardial infarction via ERK1/2 activation in isolated rat hearts

2011 ◽  
Vol 60 (5) ◽  
pp. 351 ◽  
Author(s):  
June Hong Kim ◽  
Young Ho Jang ◽  
Kook Jin Chun ◽  
Jun Kim ◽  
Yong Hyun Park ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Opioid Receptor ◽  
Receptor Activation ◽  
Kappa Opioid Receptor ◽  
Kappa Opioid ◽  
Rat Hearts ◽  
Isolated Rat

scholarly journals Kappa opioid receptor activation in the amygdala disinhibits CRF neurons to generate pain-like behaviors

2021 ◽  
Vol 185 ◽  
pp. 108456
Author(s):  
Matthew Hein ◽  
Guangchen Ji ◽  
Dalton Tidwell ◽  
Preston D'Souza ◽  
Takaki Kiritoshi ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Receptor Activation ◽  
Kappa Opioid Receptor ◽  
Kappa Opioid ◽  
Crf Neurons

Species-dependent hemodynamic effects of adenosine A3-receptor agonists IB-MECA and Cl-IB-MECA

1999 ◽  
Vol 276 (6) ◽  
pp. H2076-H2084 ◽  
Author(s):  
Robert D. Lasley ◽  
Prakash Narayan ◽  
M. Salik Jahania ◽  
Elizabeth L. Partin ◽  
Kathleen R. Kraft ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Rat Heart ◽  
Coronary Flow ◽  
Receptor Activation ◽  
Isolated Rat Heart ◽  
Pressure Effects ◽  
Hemodynamic Effects ◽  
Receptor Agonists ◽  
Coronary Dilation ◽  
Isolated Rat

The purpose of this study was to compare the hemodynamic effects of the adenosine A3-receptor agonists N 6-(3-iodobenzyl)-9-[5-(methylcarbamoyl)-β-d-ribofuranosyl]adenine (IB-MECA) and 2-chloro- N 6-(3-iodobenzyl)-9-[5-(methylcarbamoyl)-β-d-ribofuranosyl]adenine (Cl-IB-MECA) in isolated rat and rabbit hearts and in the intact, open-chest pig. Isolated hearts perfused with Krebs-Henseleit buffer at a constant pressure (70 mmHg) were treated with 50 nM of either IB-MECA or Cl-IB-MECA. Neither IB-MECA nor Cl-IB-MECA altered ventricular function or heart rate in the isolated rat and rabbit hearts, and neither agent altered coronary flow in the rabbit. However, 2 min of IB-MECA treatment in the isolated rat heart increased coronary flow by 25%, an effect that did not exhibit tachyphylaxis. The IB-MECA-induced coronary dilation was only partially attenuated by the adenosine A3-receptor antagonist MRS-1191 (50 nM). IB-MECA-induced coronary dilation was completely blocked by the adenosine A2a-receptor antagonist 7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine (Sch-58261, 50 nM). Cl-IB-MECA (50 nM) did not increase coronary flow in the rat, but 100 nM did increase flow by 18%. In pentobarbital sodium-anesthetized pigs IB-MECA (5 μg/kg iv) decreased systemic blood pressure and increased pulmonary artery pressure, effects that did exhibit tachyphylaxis. These results illustrate that adenosine A3-receptor agonists produce species-dependent effects, which in the rat heart appear to be caused by adenosine A2a-receptor activation.

scholarly journals Analgesic Activity of the Kappa Opioid Receptor Agonist RU-1205 in Rats

2018 ◽  
Vol 3 (2) ◽  
pp. 13 ◽  
Author(s):  
AA Spasov ◽  
OY Grechko ◽  
DM Shtareva ◽  
AI Raschenko ◽  
Natalia Eliseeva ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Analgesic Activity ◽  
Analgesic Effect ◽  
Physical Dependence ◽  
Receptor Activation ◽  
Kappa Opioid Receptor ◽  
Kappa Opioid ◽  
Hot Plate ◽  
Hot Plate Test ◽  
Plate Test

Introduction: Opioid analgesics are the most efficient and widely used drugs for the management of moderate to severe pain. However, side effects associated with mu receptor activation, such as respiratory depression, tolerance and physical dependence severely limit their clinical application. Currently, the kappa-opioid system is the most attractive in terms of the clinical problem of pain, because kappa-agonists do not cause euphoria and physical dependence. The purpose of this study was to evaluate the antinociceptive effect of the novel compound - RU-1205. Methods: The analgesic activity of RU-1205 was studied on nociceptive models that characterize the central and peripheral pathways of pain sensitivity (hot plate test, electrically induced vocalisation, formalin test, writhing test). Results: RU-1205 exhibited highly potent antinociceptive effects in rodent models of acute pain with ED50 values of 0.002 - 0.49 mg /kg. Pretreatment with the κ-opioid receptor antagonist norBinaltorphimine significantly attenuated the analgesic activity of investigated substance in a hot plate test. Conclusions: It was established that the compound shows a significant dose-dependent central and peripheral analgesic effect. It was assumed kappa-opioidergic mechanism of analgesic effect of RU-1205.

scholarly journals Contribution of endocannabinoids in the endothelial protection afforded by ischemic preconditioning in the isolated rat heart

Life Sciences ◽  
2003 ◽  
Vol 72 (16) ◽  
pp. 1859-1870 ◽  
Author(s):  
Jean-François Bouchard ◽  
Philippe Lépicier ◽  
Daniel Lamontagne
Keyword(s):  
Ischemic Preconditioning ◽  
Rat Heart ◽  
Isolated Rat Heart ◽  
Isolated Rat
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