scholarly journals The mechanical and metabolic basis of myocardial blood flow heterogeneity

2001 ◽  
Vol 96 (6) ◽  
pp. 582-594 ◽  
Author(s):  
James B. Bassingthwaighte ◽  
Daniel A. Beard ◽  
Zheng Li
Keyword(s):  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Flow Heterogeneity ◽  
Metabolic Basis ◽  
Blood Flow Heterogeneity

Myocardial Blood Flow Heterogeneity In Highly Endurance-trained Athletes And Untrained Control Subjects

2014 ◽  
Vol 46 ◽  
pp. 341
Author(s):  
Ilkka Heinonen ◽  
Joonas Hakala ◽  
Dirk J. Duncker ◽  
Juhani Knuuti ◽  
Kari K. Kalliokoski
Keyword(s):  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Flow Heterogeneity ◽  
Control Subjects ◽  
Blood Flow Heterogeneity

scholarly journals Fractal nature of regional myocardial blood flow heterogeneity.

1989 ◽  
Vol 65 (3) ◽  
pp. 578-590 ◽  
Author(s):  
J B Bassingthwaighte ◽  
R B King ◽  
S A Roger
Keyword(s):  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Regional Myocardial Blood Flow ◽  
Fractal Nature ◽  
Flow Heterogeneity ◽  
Blood Flow Heterogeneity ◽  
Regional Myocardial Blood

Estimation of myocardial blood flow heterogeneity by transorgan helium transport functions

1984 ◽  
Vol 401 (3) ◽  
pp. 217-222 ◽  
Author(s):  
H. G. Wolpers ◽  
V. Geppert ◽  
A. Hoeft ◽  
H. Korb ◽  
R. Schräder ◽  
...  
Keyword(s):  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Flow Heterogeneity ◽  
Blood Flow Heterogeneity

Myocardial blood flow heterogeneity in shock and small-volume resuscitation in pigs with coronary stenosis

1997 ◽  
Vol 83 (6) ◽  
pp. 1832-1841 ◽  
Author(s):  
Martin Kleen ◽  
Martin Welte ◽  
Peter Lackermeier ◽  
Oliver Habler ◽  
Gregor Kemming ◽  
...  
Keyword(s):  
Blood Flow ◽  
Myocardial Perfusion ◽  
Myocardial Blood Flow ◽  
Fluid Therapy ◽  
Coronary Stenosis ◽  
Small Volume ◽  
Volume Resuscitation ◽  
Flow Heterogeneity ◽  
Regional Myocardial Perfusion ◽  
Blood Flow Heterogeneity

Kleen, Martin, Martin Welte, Peter Lackermeier, Oliver Habler, Gregor Kemming, and Konrad Messmer. Myocardial blood flow heterogeneity in shock and small-volume resuscitation in pigs with coronary stenosis. J. Appl. Physiol.83(6): 1832–1841, 1997.—We analyzed the effects of shock and small-volume resuscitation in the presence of coronary stenosis on fractal dimension ( D) and spatial correlation (SC) of regional myocardial perfusion. Hemorrhagic shock was induced and maintained for 1 h. Pigs were resuscitated with hypertonic saline-dextran 60 [HSDex, 10% of shed blood volume (SBV)] or normal saline (NS; 80% of SBV). Therapy was continued after 30 min with dextran (10% SBV). At baseline, D was 1.39 ± 0.06 (mean ± SE; HSDex group) and 1.34 ± 0.04 (NS group). SC was 0.26 ± 0.07 (HSDex) and 0.26 ± 0.04 (NS). Left anterior descending coronary artery stenosis changed neither D nor SC. Shock significantly reduced D(i.e., homogenized perfusion): 1.26 ± 0.06 (HSDex) and 1.23 ± 0.05 (NS). SC was increased: 0.41 ± 0.1 (HSDex) and 0.48 ± 0.07 (NS). Fluid therapy with HSDex further decreased D to 1.22 ± 0.05, whereas NS did not change D. SC was increased by both HSDex (0.56 ± 0.1) and NS (0.53 ± 0.06). At 1 h after resuscitation, SC was constant in both groups, and D was reduced only in the NS group (1.18 ± 0.02). We conclude that hemorrhagic shock homogenized regional myocardial perfusion in coronary stenosis and that fluid therapy failed to restore this.

scholarly journals Computational Assessment of Blood Flow Heterogeneity in Peritoneal Dialysis Patients' Cardiac Ventricles

2018 ◽  
Vol 9 ◽  
Author(s):  
Sanjay R. Kharche ◽  
Aaron So ◽  
Fabio Salerno ◽  
Ting-Yim Lee ◽  
Chris Ellis ◽  
...  
Keyword(s):  
Blood Flow ◽  
Peritoneal Dialysis ◽  
Dialysis Patients ◽  
Flow Heterogeneity ◽  
Cardiac Ventricles ◽  
Blood Flow Heterogeneity

Blood flow distribution in working in situ canine muscle during blood flow reduction

1996 ◽  
Vol 80 (6) ◽  
pp. 1978-1983 ◽  
Author(s):  
S. S. Kurdak ◽  
B. Grassi ◽  
P. D. Wagner ◽  
M. C. Hogan
Keyword(s):  
Blood Flow ◽  
Muscle Blood Flow ◽  
Flow Distribution ◽  
Blood Flow Distribution ◽  
Strong Negative Correlation ◽  
Flow Heterogeneity ◽  
Blood Flow Reduction ◽  
Blood Flow Heterogeneity

The purpose of this study was to determine whether reduction in apparent muscle O2 diffusing capacity (Dmo2) calculated during reduced blood flow conditions in maximally working muscle is a reflection of alterations in blood flow distribution. Isolated dog gastrocnemius muscle (n = 6) was stimulated for 3 min to achieve peak O2 uptake (VO2) at two levels of blood flow (controlled by pump perfusion): control (C) conditions at normal perfusion pressure (blood flow = 111 +/- 10 ml.100 g-1.min-1) and reduced blood flow treatment [ischemia (I); 52 +/- 6 ml.100 g-1.min-1]. In addition, maximal vasodilation was achieved by adenosine (A) infusion (10(-2)M) at both levels of blood flow, so that each muscle was subjected randomly to a total of four conditions (C, CA, I, and IA; each separated by 45 min of rest). Muscle blood flow distribution was measured with 15-microns-diameter colored microspheres. A numerical integration technique was used to calculate Dmo2 for each treatment with use of a model that calculates O2 loss along a capillary on the basis of Fick's law of diffusion. Peak VO2 was reduced significantly (P < 0.01) with ischemia and was unchanged by adenosine infusion at either flow rate (10.6 +/- 0.9, 9.7 +/- 1.0, 6.7 +/- 0.2, and 5.9 +/- 0.8 ml.100 g-1.min-1 for C, CA, I, and IA, respectively). Dmo2 was significantly lower by 30-35% (P < 0.01) when flow was reduced (except for CA vs. I; 0.23 +/- 0.03, 0.20 +/- 0.02, 0.16 +/- 0.01, and 0.13 +/- 0.01 ml.100 g-1.min-1.Torr-1 for C, CA, I, and IA, respectively). As expressed by the coefficient of variation (0.45 +/- 0.04, 0.47 +/- 0.04, 0.55 +/- 0.03, and 0.53 +/- 0.04 for C, CA, I, and IA, respectively), blood flow heterogeneity per se was not significantly different among the four conditions when examined by analysis of variance. However, there was a strong negative correlation (r = 0.89, P < 0.05) between Dmo2 and blood flow heterogeneity among the four conditions, suggesting that blood flow redistribution (likely a result of a decrease in the number of perfused capillaries) becomes an increasingly important factor in the determination of Dmo2 as blood flow is diminished.

Pulmonary Blood Flow Heterogeneity during Hypoxia and High-Altitude Pulmonary Edema

2005 ◽  
Vol 171 (1) ◽  
pp. 83-87 ◽  
Author(s):  
Susan R. Hopkins ◽  
Joy Garg ◽  
Divya S. Bolar ◽  
Jamal Balouch ◽  
David L. Levin
Keyword(s):  
Blood Flow ◽  
Pulmonary Edema ◽  
High Altitude ◽  
Pulmonary Blood Flow ◽  
Flow Heterogeneity ◽  
High Altitude Pulmonary Edema ◽  
Blood Flow Heterogeneity

Evaluation of arterial blood flow heterogeneity via an image-based computational model

2005 ◽  
Author(s):  
Kelly S. Burrowes ◽  
Merryn H. Tawhai ◽  
Peter J. Hunter
Keyword(s):  
Blood Flow ◽  
Computational Model ◽  
Arterial Blood Flow ◽  
Flow Heterogeneity ◽  
Arterial Blood ◽  
Blood Flow Heterogeneity
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