Synthesis of stimuli-responsive poly(ethylene glycol) diacrylate/methacrylic acid-based nanogels and their application as drug delivery vehicle

2014 ◽  
Vol 293 (2) ◽  
pp. 441-451 ◽  
Author(s):  
Hongyan Cao ◽  
Qian Wang ◽  
Min Li ◽  
Zhiyong Chen
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Methacrylic Acid ◽  
Stimuli Responsive ◽  
Poly Ethylene Glycol ◽  
Delivery Vehicle ◽  
Glycol Diacrylate ◽  
Drug Delivery Vehicle ◽  
Poly Ethylene

Micelles of Methoxy Poly(ethylene glycol)–Poly(ε-caprolactone) as a Novel Drug Delivery Vehicle for Tacrolimus

2013 ◽  
Vol 9 (2) ◽  
pp. 147-157 ◽  
Author(s):  
Yingjing Wang ◽  
Cheng Wang ◽  
Yujun Wang ◽  
Feng Luo ◽  
Xi Yan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Delivery Vehicle ◽  
Drug Delivery Vehicle ◽  
Poly Ethylene ◽  
Novel Drug

Multi-stimuli-responsive, liposome-crosslinked poly(ethylene glycol) hydrogels for drug delivery

2020 ◽  
pp. 1-22
Author(s):  
Luisa L. Palmese ◽  
Ming Fan ◽  
Rebecca A. Scott ◽  
Huaping Tan ◽  
Kristi L. Kiick
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Stimuli Responsive ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals Composite Nanogels Based on Zeolite-Poly(ethylene glycol) Diacrylate for Controlled Drug Delivery

Nanomaterials ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 195 ◽  
Author(s):  
Catalina Paula Spatarelu ◽  
Anita-Laura (Radu) Chiriac ◽  
Bogdan Cursaru ◽  
Tanta-Verona Iordache ◽  
Ana-Mihaela Gavrila ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Natural Zeolite ◽  
Drug Loading ◽  
Controlled Drug Delivery ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
Preparation Conditions ◽  
Transmission Electron ◽  
Poly Ethylene

This study presents the design of novel composites nanogels, based on poly(ethylene glycol) diacrylate and natural zeolite particles, that are able to act as materials with controlled drug delivery properties. Natural zeolite–nanogels composite, with varying zeolite contents, were obtained by an inverse mini-emulsion technique and loaded with 5-fluorouracil, a widely used chemotherapeutic drug. Herein, the possibility of adjusting final properties by means of modifying the preparation conditions was investigated. The prepared composite nanogels are characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). In light of this tunable drug-loading capability, swelling behaviour, and cytotoxicity, these composite nanogels could be highly attractive as drug reservoirs.

Drug Delivery From Poly(ethylene glycol) Diacrylate Scaffolds Produced by DLC Based Micro-Stereolithography

2014 ◽  
Vol 346 (1) ◽  
pp. 43-47 ◽  
Author(s):  
Mark Vehse ◽  
Svea Petersen ◽  
Katrin Sternberg ◽  
Klaus-Peter Schmitz ◽  
Hermann Seitz
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
Poly Ethylene

RAFT Polymerization of Dual Responsive Hyperbranched-Star Copolymers of Methacrylic Acid and Poly(Ethylene Glycol)

2017 ◽  
Vol 890 ◽  
pp. 78-81 ◽  
Author(s):  
Eduardo C. Atayde Jr. ◽  
Monica M. Berenguel ◽  
Susan D. Arco
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Methacrylic Acid ◽  
Morphological Changes ◽  
Spectroscopic Techniques ◽  
Block Copolymerization ◽  
Poly Ethylene Glycol ◽  
Dual Responsive ◽  
Star Copolymers ◽  
Poly Ethylene

Smart polymers are materials that respond to external stimuli via reversible morphological changes, making them potential systems for drug delivery applications. In this study, dual-responsive star copolymers with a hyperbranched core composed of ethylene glycol dimethacrylate (EGDMA) - methacrylic acid (MAA) and poly(ethylene glycol) methyl ether methacrylate (PEGMA) arms were synthesized via two-step Reversible Addition-fragmentation Chain Transfer (RAFT) block copolymerization. The synthesis involved the formation of the hyperbranched MAA core followed by arm extension with PEGMA. The formation of the hyperbranched core and subsequent copolymerization with PEGMA were verified by FT-IR and 1H-NMR spectroscopic techniques. The distinct EGDMA peak was found at 4.3 ppm while the peak attributed to PEGMA was found at around 3.5 ppm. Furthermore, the synthesized block copolymers were both temperature and pH-responsive with LCST value at 57°C and morphological transition at pH 5.6. The synthesized smart polymer was also biocompatible based on Trypan blue cytotoxicity assay. The inherent dual responsive behavior and biocompatibility of the copolymer render it a good candidate for drug delivery systems.

Novel pH-Sensitive Hydrogels with Peg-Tethered Chains for Oral Delivery of Calcitonin

1998 ◽  
Vol 550 ◽  
Author(s):  
M. Torres-Lugo ◽  
N.A. Peppas
Keyword(s):  
Drug Delivery ◽  
Ionic Strength ◽  
Ethylene Glycol ◽  
Methacrylic Acid ◽  
Salmon Calcitonin ◽  
Oral Delivery ◽  
Ph Sensitive ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Tethered Chains

AbstractMajor challenges in oral delivery of peptides include the need to overcome gastric and intestinal degradation. pH -Sensitive hydrogels are suitable candidates for oral drug delivery of peptides due to their ability to respond to their environment. We have developed a new type of hydrogel composed of poly(methacrylic acid) grafted with poly(ethylene glycol) which can be used as drug delivery carriers for salmon calcitonin. These hydrogels were prepared by free radical solution polymerization and were molecularly designed to contain poly(ethylene glycol) tethered chains promoting mucosal adhesion and providing calcitonin protection, as well as methacrylic acid moieties, which act as calcium binders leading to epithelial cell junction opening. Solutions of approximately 0.1 mg/ml of salmon calcitonin were used to load the protein into the gels at pH = 7 and constant ionic strength of 0.1 M. In vitro release studies were performed at pH=7 and 37 °C, while keeping an ionic strength of 0.1 M. Calcitonin release was achieved. The release behavior was explained in terms of diffusional theories.

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