Analysis of granulation mechanism in a high-shear wet granulation method using near-infrared spectroscopy and stirring power consumption

2020 ◽  
Vol 298 (8) ◽  
pp. 977-987 ◽  
Author(s):  
Keita Koyanagi ◽  
Akinori Ueno ◽  
Yusuke Hattori ◽  
Tetsuo Sasaki ◽  
Tomoaki Sakamoto ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Power Consumption ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Wet Granulation ◽  
High Shear ◽  
High Shear Wet Granulation ◽  
Granulation Mechanism

scholarly journals Real-time monitoring of granule properties during high shear wet granulation by near-infrared spectroscopy with a chemometrics approach

RSC Advances ◽  
2017 ◽  
Vol 7 (61) ◽  
pp. 38307-38317 ◽  
Author(s):  
F. Shikata ◽  
S. Kimura ◽  
Y. Hattori ◽  
M. Otsuka
Keyword(s):  
Infrared Spectroscopy ◽  
Real Time ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Wet Granulation ◽  
High Shear ◽  
Monitoring Method ◽  
Granulation Process ◽  
High Shear Wet Granulation ◽  
Granule Properties

An in-line near-infrared spectroscopy monitoring method was developed for analyzing granule properties during a high shear wet granulation process.

Comparison of torque measurements and near-infrared spectroscopy in characterization of a wet granulation process

2004 ◽  
Vol 93 (9) ◽  
pp. 2232-2243 ◽  
Author(s):  
Anna Cecilia Jørgensen ◽  
Pirjo Luukkonen ◽  
Jukka Rantanen ◽  
Torben Schæfer ◽  
Anne Mari Juppo ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Wet Granulation ◽  
Granulation Process ◽  
Torque Measurements

scholarly journals Elucidation of the Molecular Mechanism of Wet Granulation for Pharmaceutical Standard Formulations in a High-Speed Shear Mixer Using Near-Infrared Spectroscopy

2020 ◽  
Vol 13 (9) ◽  
pp. 226 ◽  
Author(s):  
Ryo Omata ◽  
Yusuke Hattori ◽  
Tetsuo Sasaki ◽  
Tomoaki Sakamoto ◽  
Makoto Otsuka
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
High Speed ◽  
Near Infrared ◽  
Potato Starch ◽  
Particle Surface ◽  
Wet Granulation ◽  
Chemical Information ◽  
Calibration Model ◽  
Least Squares Regression

The granulation process of pharmaceutical standard formulation in a high-speed shear wet granulation (HSWG) was measured by in-line near-infrared spectroscopy (NIRS) and agitation power consumption (APC) methods. The F-1, F-2, and F-3 formulations (500 g) contained 96% w/w α-lactose monohydrate (LA), potato starch (PS), and a LA:PS = 7:3 mixture, respectively, and all the formulations contained 4% w/w hydroxypropyl cellulose. While adding purified water at 10 mL/min, the sample powder was mixed. The calibration models to measure the amount of binding water (Wa) and APC of the HSWG formulations were established based on NIRS of the samples measured for 60 min by partial least-squares regression analysis (PLS). Molecular interaction related to APC between the particle surface and binding liquor was analyzed based on NIRS. The predicted values of Wa and APC for all formulations were superimposed with the measured values on a straight line, respectively. The regression vector (RV) of the calibration model for Wa indicated the chemical information of all the water in the samples. In contrast, the RV for APC suggested that APC changes in the processes are related to powder aggregation because of surface tension of binding water between particles.

Novel Identification of Pseudopolymorphic Changes of Theophylline During Wet Granulation Using Near Infrared Spectroscopy

2001 ◽  
Vol 90 (3) ◽  
pp. 389-396 ◽  
Author(s):  
Eetu Räsänen ◽  
Jukka Rantanen ◽  
Anna Jørgensen ◽  
Milja Karjalainen ◽  
Timo Paakkari ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Wet Granulation
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