De-risking Scale-up of a High Shear Wet Granulation Process Using Latent Variable Modeling and Near-Infrared Spectroscopy

2011 ◽  
Vol 6 (3) ◽  
pp. 142-156 ◽  
Author(s):  
Koji Muteki ◽  
Ken Yamamoto ◽  
George L. Reid ◽  
Mahesh Krishnan
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Latent Variable ◽  
Near Infrared ◽  
Scale Up ◽  
Latent Variable Modeling ◽  
Wet Granulation ◽  
High Shear ◽  
Granulation Process ◽  
High Shear Wet Granulation

scholarly journals Real-time monitoring of granule properties during high shear wet granulation by near-infrared spectroscopy with a chemometrics approach

RSC Advances ◽  
2017 ◽  
Vol 7 (61) ◽  
pp. 38307-38317 ◽  
Author(s):  
F. Shikata ◽  
S. Kimura ◽  
Y. Hattori ◽  
M. Otsuka
Keyword(s):  
Infrared Spectroscopy ◽  
Real Time ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Wet Granulation ◽  
High Shear ◽  
Monitoring Method ◽  
Granulation Process ◽  
High Shear Wet Granulation ◽  
Granule Properties

An in-line near-infrared spectroscopy monitoring method was developed for analyzing granule properties during a high shear wet granulation process.

scholarly journals Scale-Up Studies on High Shear Wet Granulation Process from Mini-Scale to Commercial Scale

2008 ◽  
Vol 56 (10) ◽  
pp. 1431-1435 ◽  
Author(s):  
Shouhei Aikawa ◽  
Naomi Fujita ◽  
Hidetoshi Myojo ◽  
Takashi Hayashi ◽  
Tadatsugu Tanino
Keyword(s):  
Scale Up ◽  
Wet Granulation ◽  
High Shear ◽  
Granulation Process ◽  
Commercial Scale ◽  
High Shear Wet Granulation

Evaluating Scale-Up Rules of a High-Shear Wet Granulation Process

2015 ◽  
Vol 104 (7) ◽  
pp. 2323-2333 ◽  
Author(s):  
Jing Tao ◽  
Preetanshu Pandey ◽  
Dilbir S. Bindra ◽  
Julia Z. Gao ◽  
Ajit S. Narang
Keyword(s):  
Scale Up ◽  
Wet Granulation ◽  
High Shear ◽  
Granulation Process ◽  
High Shear Wet Granulation

Comparison of torque measurements and near-infrared spectroscopy in characterization of a wet granulation process

2004 ◽  
Vol 93 (9) ◽  
pp. 2232-2243 ◽  
Author(s):  
Anna Cecilia Jørgensen ◽  
Pirjo Luukkonen ◽  
Jukka Rantanen ◽  
Torben Schæfer ◽  
Anne Mari Juppo ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Wet Granulation ◽  
Granulation Process ◽  
Torque Measurements

Scale-up of a high shear wet granulation process using a nucleation regime map approach

Particuology ◽  
2017 ◽  
Vol 31 ◽  
pp. 87-94 ◽  
Author(s):  
Gan Luo ◽  
Bing Xu ◽  
Yi Zhang ◽  
Xianglong Cui ◽  
Jianyu Li ◽  
...  
Keyword(s):  
Scale Up ◽  
Wet Granulation ◽  
High Shear ◽  
Granulation Process ◽  
Regime Map ◽  
High Shear Wet Granulation ◽  
Map Approach

Closing the gap in series scale up of high shear wet granulation process using impeller power and blade design

2011 ◽  
Vol 205 (1-3) ◽  
pp. 184-192 ◽  
Author(s):  
Gossett A. Campbell ◽  
Donald J. Clancy ◽  
Jinzhou X. Zhang ◽  
Manish K. Gupta ◽  
Choon K. Oh
Keyword(s):  
Scale Up ◽  
Wet Granulation ◽  
High Shear ◽  
Blade Design ◽  
Granulation Process ◽  
In Series ◽  
Closing The Gap ◽  
High Shear Wet Granulation
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