Absence of anti-human herpesvirus 8 antibody in 32 Japanese hemophiliacs with advanced HIV infection

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Author(s):  
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Harutaka Katano ◽  
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Ko-Ron Chen ◽  
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...  
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Musa Fares Alzahrani ◽  
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Heather A. Leitch

Castleman's disease (CD) is a rare lymphoproliferative disorder that is most commonly present in multicentric (MCD) form in association with HIV infection. Interleukin-6 (IL-6) and human herpesvirus-8 (HHV-8) play major roles in MCD pathogenesis. Important treatment options have recently become available, particularly with the introduction of IL-6 and IL-6 receptor inhibitors for the treatment of HIV-negative patients with MCD. Though advances in therapy may improve outcomes in some patients, the prognosis remains guarded, and a stratified approach to the management of MCD is needed.


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Vol 56 (6) ◽  
pp. 833-842 ◽  
Author(s):  
A. Dossier ◽  
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