Malignant transformation in mature cystic teratoma of the ovary: report of five cases and review of the literature

Abstract Background Mature Cystic Teratoma (MCT) is a benign tumor that can lead to malignant transformation (MT) in 1–3% of cases. Management of MT is a big challenge for gynecologic oncologists due to the lack of specific diagnostic and treatment protocols. Case presentation We reported two Iranian cases of MT of MCT with two different stages and prognosis. Our both cases presented the same symptoms, including chronic abdominal pain and distention, loss of appetite, and weight loss. In case number 1, despite the large size of the tumor, the disease was at stage Ia and had a good prognosis; while, case number 2 was at stage IIIc of the disease with a poor prognosis. Conclusion The stage of the disease is the most important prognostic factor, and early diagnosis and treatment are very critical for better survival.

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O935 Malignant transformation of ovarian mature cystic teratoma to intestinal adenocarcinoma

International Journal of Gynecology & Obstetrics ◽

10.1016/s0020-7292(09)61308-4 ◽

2009 ◽

Vol 107 ◽

pp. S359-S359

Author(s):

N. Thomakos ◽

A. Vlismas ◽

A. Rodolakis ◽

M. Sotiropoulou ◽

P. Drakakis ◽

...

Keyword(s):

Malignant Transformation ◽

Cystic Teratoma ◽

Mature Cystic Teratoma

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Squamous cell carcinoma in mature cystic teratoma of the ovary

Medicinski pregled ◽

10.2298/mpns1210429a ◽

2012 ◽

Vol 65 (9-10) ◽

pp. 429-431 ◽

Cited By ~ 2

Author(s):

Jelena Amidzic ◽

Matilda Djolai ◽

Mihaela Mocko-Kacanski ◽

Aleksandar Gluhovic ◽

Jelena Ilic ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Malignant Transformation ◽

Squamous Cell ◽

Rare Complication ◽

Cystic Teratoma ◽

Internal Surface ◽

Cystic Mass ◽

Mature Cystic Teratoma ◽

Well Differentiated

Introduction. Malignant transformation is a rare complication of mature cystic teratoma, with squamous cell carcinoma as the most common malignancy (in 75% of cases). In this article we present a case of a well-differentiated squamous cell carcinoma arising in a mature cystic teratoma and discuss the morphological and clinico-pathological features of malignant transformation in teratoma. Case Report. An 80-year-old woman with symptoms of acute abdomen underwent left salpingo-oophorectomy. Gross examination showed a cystic mass measuring 20 cm in diameter, with papillary formation on its internal surface. Histology revealed a well-differentiated squamous cell carcinoma arising in mature cystic teratoma. Squamous epithelium surrounding the tumor was dysplastic. Conclusion. Squamous cell carcinoma in mature cystic teratoma is a rare pathologic event and in most cases it is an accidental pathohistological finding.

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Mature cystic teratoma with neurogenic components and struma ovarii: a rare case report and review of the literature

Kasr Al Ainy Medical Journal ◽

10.4103/kamj.kamj_17_17 ◽

2017 ◽

Vol 23 (3) ◽

pp. 154

Author(s):

Seema Dayal

Keyword(s):

Case Report ◽

Rare Case ◽

Cystic Teratoma ◽

Mature Cystic Teratoma ◽

Struma Ovarii ◽

Review Of The Literature ◽

Rare Case Report

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Advanced Mucinous Adenocarcinoma Arising from a Mature Cystic Teratoma: A Case Report and Literature Review

Case Reports in Oncology ◽

10.1159/000447258 ◽

2016 ◽

Vol 9 (2) ◽

pp. 331-337

Author(s):

Aki Miyasaka ◽

Tadaaki Nishikawa ◽

Eito Kozawa ◽

Masanori Yasuda ◽

Keiichi Fujiwara ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Case Report ◽

Literature Search ◽

Abdominal Mass ◽

Cystic Teratoma ◽

Figo Stage ◽

Mature Cystic Teratoma ◽

Advanced Stage ◽

Review Of The Literature ◽

Progressive Course

Purpose: To describe the postoperative progressive course of advanced-stage adenocarcinoma arising from a mature cystic teratoma (MCT) and review the literature regarding this disease. Methods: A 59-year-old woman visited our hospital with an abdominal mass. Laparotomy showed enlargement of the left ovary and dissemination throughout the abdominal and pelvic cavities. The diagnosis was FIGO stage IIIB adenocarcinoma arising from a MCT. We report this case in detail with a review of the literature. Results: A literature search yielded 9 cases of stage III adenocarcinoma with malignant transformation. Six of these 9 patients died within 12 months after diagnosis. Of the 8 patients who underwent postoperative chemotherapy, 3 survived for over 39 months. The review indicates that prognosis of adenocarcinoma is as poor as that for squamous cell carcinoma arising from a MCT. Conclusions: In general, as with this case, prognosis of advanced adenocarcinoma associated with a MCT is poor. However, we should be aware that not all patients are resistant to chemotherapy.

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