Ovarian mature cystic teratoma with malignant transformation: two case reports

Abstract Background Mature Cystic Teratoma (MCT) is a benign tumor that can lead to malignant transformation (MT) in 1–3% of cases. Management of MT is a big challenge for gynecologic oncologists due to the lack of specific diagnostic and treatment protocols. Case presentation We reported two Iranian cases of MT of MCT with two different stages and prognosis. Our both cases presented the same symptoms, including chronic abdominal pain and distention, loss of appetite, and weight loss. In case number 1, despite the large size of the tumor, the disease was at stage Ia and had a good prognosis; while, case number 2 was at stage IIIc of the disease with a poor prognosis. Conclusion The stage of the disease is the most important prognostic factor, and early diagnosis and treatment are very critical for better survival.

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Malignant Transformation of Mature Cystic Teratoma Diagnosed after a 10-Year Interval

Case Reports in Obstetrics and Gynecology ◽

10.1155/2017/2947927 ◽

2017 ◽

Vol 2017 ◽

pp. 1-4

Author(s):

Mariko Jitsumori ◽

Satoru Munakata ◽

Toshiya Yamamoto

Keyword(s):

Incisional Hernia ◽

Malignant Transformation ◽

Cystic Teratoma ◽

Mature Cystic Teratoma ◽

Appetite Loss ◽

Perforated Gastric Ulcer ◽

Chief Complaints ◽

Stage Ia ◽

The Right ◽

Mural Nodules

A 67-year-old uniparous woman had undergone surgery for acute perforated gastric ulcer 10 years prior to the current presentation. Although abdominal computed tomography (CT) performed at that point had revealed a mature cystic teratoma measuring 6 cm in diameter in the right ovary, it was left untreated. She visited the department of surgery at our hospital with chief complaints of appetite loss, nausea, and vomiting that had persisted for the prior two weeks. She was admitted with a diagnosis of ileus attributed to an abdominal incisional hernia. CT performed on admission revealed a tumor measuring 21 cm in diameter with mural nodules in the right ovary. Thus, surgery was performed under suspicion of malignant transformation of the previously detected ovarian mature cystic teratoma. While neither lymphadenopathy nor distant metastasis was detected by imaging studies, bilateral adnexectomy and repair of the abdominal incisional hernia were performed. Cytology of ascites was negative. The postoperative pathological diagnosis was squamous cell carcinoma arising from teratoma, and the postoperative clinical diagnosis was stage IA ovarian cancer. It was assumed that the mature cystic teratoma which had been detected in the right ovary 10 years earlier had undergone malignant transformation.

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O935 Malignant transformation of ovarian mature cystic teratoma to intestinal adenocarcinoma

International Journal of Gynecology & Obstetrics ◽

10.1016/s0020-7292(09)61308-4 ◽

2009 ◽

Vol 107 ◽

pp. S359-S359

Author(s):

N. Thomakos ◽

A. Vlismas ◽

A. Rodolakis ◽

M. Sotiropoulou ◽

P. Drakakis ◽

...

Keyword(s):

Malignant Transformation ◽

Cystic Teratoma ◽

Mature Cystic Teratoma

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Squamous cell carcinoma in mature cystic teratoma of the ovary

Medicinski pregled ◽

10.2298/mpns1210429a ◽

2012 ◽

Vol 65 (9-10) ◽

pp. 429-431 ◽

Cited By ~ 2

Author(s):

Jelena Amidzic ◽

Matilda Djolai ◽

Mihaela Mocko-Kacanski ◽

Aleksandar Gluhovic ◽

Jelena Ilic ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Malignant Transformation ◽

Squamous Cell ◽

Rare Complication ◽

Cystic Teratoma ◽

Internal Surface ◽

Cystic Mass ◽

Mature Cystic Teratoma ◽

Well Differentiated

Introduction. Malignant transformation is a rare complication of mature cystic teratoma, with squamous cell carcinoma as the most common malignancy (in 75% of cases). In this article we present a case of a well-differentiated squamous cell carcinoma arising in a mature cystic teratoma and discuss the morphological and clinico-pathological features of malignant transformation in teratoma. Case Report. An 80-year-old woman with symptoms of acute abdomen underwent left salpingo-oophorectomy. Gross examination showed a cystic mass measuring 20 cm in diameter, with papillary formation on its internal surface. Histology revealed a well-differentiated squamous cell carcinoma arising in mature cystic teratoma. Squamous epithelium surrounding the tumor was dysplastic. Conclusion. Squamous cell carcinoma in mature cystic teratoma is a rare pathologic event and in most cases it is an accidental pathohistological finding.

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Malignant transformation of an ovary mature cystic teratoma: case report and review of the literature

Obstetrics & Gynecology International Journal ◽

10.15406/ogij.2019.10.00426 ◽

2019 ◽

Vol 10 (2) ◽

Author(s):

Elkin Fabián Dorado-Roncancio ◽

Oscar Joel Carrillo-Garibaldi

Keyword(s):

Case Report ◽

Malignant Transformation ◽

Cystic Teratoma ◽

Mature Cystic Teratoma ◽

Review Of The Literature

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Rare giant: mature cystic teratoma in the liver

Journal of Surgical Case Reports ◽

10.1093/jscr/rjz347 ◽

2019 ◽

Vol 2019 (12) ◽

Author(s):

Manuel Jaklitsch ◽

Mafalda Sobral ◽

António Augusto Ferreira Pinto de Figueiredo ◽

Americo Martins ◽

Hugo Pinto Marques

Keyword(s):

Elective Surgery ◽

Age Groups ◽

Cystic Teratoma ◽

Longitudinal Axis ◽

Mature Cystic Teratoma ◽

Liver Mass ◽

Complete Surgical Resection ◽

History Of ◽

Cystic Liver ◽

Loss Of Appetite

Abstract Teratomas are rare pluripotent embryonic tumours occurring mostly in gonadal organs and pediatric age groups. Mature cystic teratoma in the liver are rare, and to the best of our knowledge, only a dozen cases in adults have been published in the literature. We present a 27-year-old female who had a history of loss of appetite and mild abdominal distention. Computed Tomography revealed a liver mass suggestive of teratoma. The patient underwent elective surgery, and the diagnosis of mature cystic liver teratoma was confirmed histologically. Measuring 23 cm in a longitudinal axis, the patient had an uneventful post-operative evolution and was discharged on day eight. Teratomas in the liver are a rare finding, especially in adults, mostly due to their asymptomatic evolution. Due to the possibility of malignant transformation, complete surgical resection remains the best treatment option.

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