<b><i>Introduction:</i></b> The aim of this study was to identify the rates of 2 phenotypes of intra-amniotic inflammation: intra-amniotic infection (with microbial invasion of the amniotic cavity [MIAC]) and sterile intra-amniotic inflammation (without MIAC), and their outcomes, among women with cervical insufficiency with prolapsed fetal membranes. <b><i>Methods of Study:</i></b> This is a retrospective study of women admitted to the Department of Obstetrics and Gynecology, University Hospital Hradec Kralove between January 2014 and May 2020. Transabdominal amniocentesis to evaluate intra-amniotic inflammation (amniotic fluid interleukin-6) and MIAC (culturing and molecular biology methods) was performed as part of standard clinical management. <b><i>Results:</i></b> In total, 37 women with cervical insufficiency and prolapsed fetal membranes were included; 11% (4/37) and 43% (16/37) of them had intra-amniotic infection and sterile intra-amniotic inflammation, respectively. In women with intra-amniotic infection and sterile intra-amniotic inflammation, we noted shorter intervals between admission and delivery (both <i>p</i> < 0.0001), and lower gestational age at delivery (<i>p</i> < 0.0001 and <i>p</i> = 0.004) and percentiles of birth/abortion weight (<i>p</i> = 0.03 and <i>p</i> = 0.009, respectively) than in those without intra-amniotic inflammation. <b><i>Conclusions:</i></b> Both phenotypes of intra-amniotic inflammation, with sterile intra-amniotic inflammation being more frequent, are associated with worse outcomes in pregnancies with cervical insufficiency with prolapsed fetal membranes.
Double Cerclage In Cervical Insufficiency: A Single Tertiary Center Experience
