A double-blind randomized clinical trial of different doses of transdermal nicotine patch for smoking reduction and cessation in long-term hospitalized schizophrenic patients

2012 ◽  
Vol 263 (1) ◽  
pp. 75-82 ◽  
Author(s):  
Hsing-Kang Chen ◽  
Tsuo-Hung Lan ◽  
Bo-Jian Wu
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Nicotine Patch ◽  
Smoking Reduction ◽  
Double Blind ◽  
Transdermal Nicotine ◽  
Schizophrenic Patients ◽  
Transdermal Nicotine Patch ◽  
Different Doses

Essential oils in one-stage full-mouth disinfection: double-blind, randomized clinical trial of long-term clinical, microbial and salivary effects

2009 ◽  
Vol 36 (4) ◽  
pp. 333-342 ◽  
Author(s):  
Sheila Cavalca Cortelli ◽  
José Roberto Cortelli ◽  
Marinella Holzhausen ◽  
Gilson Cesar Nobre Franco ◽  
Renato Zanotta Rebelo ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Essential Oils ◽  
Randomized Clinical Trial ◽  
Double Blind ◽  
One Stage ◽  
Full Mouth Disinfection

A Double-Blind Trial of a 16-Hour Transdermal Nicotine Patch in Smoking Cessation

1991 ◽  
Vol 325 (5) ◽  
pp. 311-315 ◽  
Author(s):  
Philip Tonnesen ◽  
Jesper Norregaard ◽  
Kåre Simonsen ◽  
Urbain Säwe
Keyword(s):  
Smoking Cessation ◽  
Nicotine Patch ◽  
Double Blind Trial ◽  
Double Blind ◽  
Blind Trial ◽  
Transdermal Nicotine ◽  
Transdermal Nicotine Patch

scholarly journals Evaluation of the efficacy of a topical chamomile-pumpkin oleogel for the treatment of plaque psoriasis: an intra-patient, double-blind, randomized clinical trial

2018 ◽  
Vol 5 (11) ◽  
pp. 2811-2819
Author(s):  
Sima Kolahdooz ◽  
Mehrdad Karimi ◽  
Nafiseh Esmaili ◽  
Arman Zargaran ◽  
Gholamreza Kordafshari ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Placebo Group ◽  
Side Effects ◽  
Randomized Clinical Trial ◽  
Plaque Psoriasis ◽  
Severity Index ◽  
Double Blind ◽  
The Mean ◽  
Psoriasis Severity

Background: Plaque psoriasis is a chronic inflammatory skin disease. Conventional treatments of psoriasis are not completely effective. In addition, unwanted side effects limit their long-term use. In this regard, developing new natural treatments with fewer side effects could be an alternative option. This study was designed to evaluate the efficacy and safety of topical chamomile-pumpkin oleogel (ChP) in treating plaque psoriasis. Methods: A total of 40 patients with mild-to-moderate plaque psoriasis were enrolled in this intra-patient, double-blind, block-randomized clinical trial. In each patient, bilateral symmetrical plaques were treated with ChP or placebo twice daily for four weeks. For clinical assessment, the Psoriasis Severity Index (PSI) and the Physician's Global Assessment (PGA) scale were evaluated at baseline and after the treatment. At the end of the study, patients' satisfaction with the treatment was evaluated using a visual analog scale (VAS) ranging from 0 to 10. For safety assessment, all treatment-related side effects were recorded. Results: Thirty-seven subjects (20 female, 17 male; age 20–60 years) completed the study. The mean decreases in the PSI score in the ChP group (4.09 +/- 2.24) were significantly (p = 0.000) greater than the placebo group (0.48 +/- 1.39). According to the PGA results, 13/37 (35%) of the ChP-treated plaques could achieve marked to complete improvement compared to 0% in the placebo group. Three patients dropped out from the study due to worsening of bilateral plaques during the first week of trial. Conclusion: Our results suggest that topically applied ChP could provide a safe and effective complementary option for psoriasis plaque management. IRCT registration code: IRCT2016092830030N1.  

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