Effects of Different Doses of Dexamethasone on Blood Glucose Concentration in Patients Undergoing Elective Abdominal Surgery: A Double-Blind Randomized Clinical Trial

Ten trained male runners performed a treadmill exercise test at 80%under two experimental conditions, carbohydrate (CHO, 7% carbohydrate) and placebo (P), to determine the effect of carbohydrate ingestion on endurance performance (treadmill run time), blood glucose concentration, respiratory exchange ratio (RER), and subjective ratings of perceived exertion (RPE). Treatment order was randomized and counterbalanced and test solutions were administered double-blind. Ingestion took place 5 min preexercise (250 ml) and at 15-min intervals during exercise (125 ml). Performance was enhanced by 29.4% (p~ 0.05) during CHO (115 ±25 min) compared to P (92 ± 27 min). Blood glucose concentration was significantly greater during CHO (5.6 ± 0.9 mM) relative to P (5.0 ±0.7 mM). There was a significant increase in mean RER following CHO ingestion (.94±.01) compared to P (.90±.01). Average RPE was significantly less during CHO (14.5±2.3) relative to P (15.4±2.4). These data suggest that time to exhaustion of high-intensity treadmill exercise is delayed as a result of carbohydrate ingestion and that this effect is mediated by favorable alterations in blood glucose concentration and substrate utilization.

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Faculty of 1000 evaluation for Bispectral index-guided induction of general anaesthesia in patients undergoing major abdominal surgery using propofol or etomidate: a double-blind, randomized, clinical trial.

F1000 - Post-publication peer review of the biomedical literature ◽

10.3410/f.717964874.793474488 ◽

2013 ◽

Author(s):

Frédérique Servin

Keyword(s):

Clinical Trial ◽

Abdominal Surgery ◽

General Anaesthesia ◽

Randomized Clinical Trial ◽

Bispectral Index ◽

Major Abdominal Surgery ◽

Double Blind

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Comparisons of tramadol with pethidine for prevention of post anaesthetic shivering in elective abdominal surgery

Health Renaissance ◽

10.3126/hren.v10i3.7139 ◽

2012 ◽

Vol 10 (3) ◽

pp. 220-223

Author(s):

SN Singh ◽

BP Sah ◽

A Ghimire ◽

JN Prasad ◽

DD Baral

Keyword(s):

Clinical Trial ◽

Adverse Effects ◽

Abdominal Surgery ◽

Respiratory Depression ◽

Respiratory System ◽

Nausea And Vomiting ◽

Unknown Etiology ◽

Double Blind ◽

Elective Abdominal Surgery ◽

Arterial O2 Saturation

Background: Postoperative shivering is a common event of unknown etiology. Objectives: To compare the efficiency of tramadol with that of pethidine in controlling post anaesthetic shivering. Methods: This double . blind randomized clinical trial was performed on 120 consecutive patients who received general anaesthesia for elective abdominal surgery. Intravenous tramadol (1mg.kg-1) or pethidine (0.5mg.kg-1) was administered to alternate subjects who developed post anaestheic shivering. They were monitored in the recovery room for 1 hour and the cessation time of shivering, recurrence of the events, duration of recovery, respiratory depression, arterial O2 saturation, nausea and vomiting were recorded. Results: Forty-eight patients (40%) had post anaesthetic shivering. In the tramadol group, shivering terminated within 5 minutes after injection. They had no recurrence of shivering, respiratory depression, reduction in SPO2, nausea and vomiting during the period of recovery. In the pethidine group, shivering terminated within 8 minutes after injection, but in 7 patients it recurred after 30 minutes. Similarly, 6 patients had respiratory depression, reduction in SPO2 and 10 patients had nausea, vomiting but none of them needed further medication. Conclusion: Tramadol is superior to pethidine as it induces a faster termination of post anaesthetic shivering and does not entail adverse effects on the respiratory system. DOI: http://dx.doi.org/10.3126/hren.v10i3.7139 Health Renaissance; September-December 2012; Vol 10 (No.3);220-223

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Blood glucose concentration profile after 10 mg dexamethasone in nondiabetic and type 2 diabetic patients undergoing abdominal surgery

Yearbook of Anesthesiology and Pain Management ◽

10.1016/s1073-5437(08)70022-6 ◽

2007 ◽

Vol 2007 ◽

pp. 20

Author(s):

H.T. Lee

Keyword(s):

Blood Glucose ◽

Abdominal Surgery ◽

Concentration Profile ◽

Glucose Concentration ◽

Blood Glucose Concentration ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Type 2 Diabetic

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A double-blind randomized clinical trial of different doses of transdermal nicotine patch for smoking reduction and cessation in long-term hospitalized schizophrenic patients

European Archives of Psychiatry and Clinical Neuroscience ◽

10.1007/s00406-012-0338-3 ◽

2012 ◽

Vol 263 (1) ◽

pp. 75-82 ◽

Cited By ~ 12

Author(s):

Hsing-Kang Chen ◽

Tsuo-Hung Lan ◽

Bo-Jian Wu

Keyword(s):

Clinical Trial ◽

Randomized Clinical Trial ◽

Nicotine Patch ◽

Smoking Reduction ◽

Double Blind ◽

Transdermal Nicotine ◽

Schizophrenic Patients ◽

Transdermal Nicotine Patch ◽

Different Doses

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The Comparative Effect on Satiety and Subsequent Energy Intake of Ingesting Sucrose or Isomaltulose Sweetened Trifle: A Randomized Crossover Trial

Nutrients ◽

10.3390/nu10101504 ◽

2018 ◽

Vol 10 (10) ◽

pp. 1504 ◽

Cited By ~ 2

Author(s):

Fiona Kendall ◽

Olivia Marchand ◽

Jillian Haszard ◽

Bernard Venn

Keyword(s):

Blood Glucose ◽

Energy Intake ◽

Glucose Concentration ◽

Crossover Trial ◽

Blood Glucose Concentration ◽

Area Under The Curve ◽

Double Blind ◽

Satiety Response ◽

Diet Records ◽

Significant Difference

The effect that blood glucose concentration has on feelings of satiety is unclear. Our aims were to assess satiety and subsequent energy intake following the ingestion of trifle sweetened with sucrose or isomaltulose whilst measuring plasma glucose concentration to confirm glycemic differences between trifles. Seventy-seven healthy adults participated in a double-blind crossover trial where trifle sweetened with sucrose or isomaltulose was consumed on separate days with a two-week washout. Blood was sampled at the baseline, 1 and 2 h postprandially, and satiety assessed using visual analogue scales (VAS). Weighed diet records were taken on test days. A statistically significant difference in blood glucose concentration between trifles was found at 60 min following consumption, with the isomaltulose trifle having a 0.69 mmol/L (95% confidence interval: −1.07, −0.31) lower concentration when compared with the sucrose trifle. Mean satiety response by area-under-the-curve (AUC) was not significantly different between trifles. Mean (SD) appetite scores for the sucrose and isomaltulose trifles were 4493 (2393) and 4527 (2590) mm·min, respectively, with a between trifle difference of −9 (95% CI: −589, 572) mm·min. Mean (SD) energy intake for the remainder of the day following trifle consumption was 3894 kJ (1950 kJ) and 3530 kJ (1926 kJ) after the sucrose and isomaltulose trifles, respectively, and was not significantly different (p = 0.133). The differing glycemic response to trifle was not related to satiety or to subsequent energy intake.

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