Stabilization of Lung Function and Clinical Symptoms in a Patient with Cystic Fibrosis (CF) After Institution of Infliximab: A Monoclonal Antibody that Binds Tumor Necrosis Factor alpha

Lung ◽  
2009 ◽  
Vol 187 (3) ◽  
pp. 149-152 ◽  
Author(s):  
Brian Casserly ◽  
Walter Donat
Keyword(s):  
Cystic Fibrosis ◽  
Monoclonal Antibody ◽  
Tumor Necrosis Factor ◽  
Lung Function ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Clinical Symptoms ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals An anti-human recombinant tumor necrosis factor alpha (TNF?) monoclonal antibody recognizes an epitope in feline TNF?

2003 ◽  
Vol 34 (2) ◽  
pp. 177-184 ◽  
Author(s):  
Adam Aguirre ◽  
Alejandro Escobar ◽  
Viviana Ferreira ◽  
Mar�a C. Molina ◽  
Arturo Ferreira ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Recombinant Tumor Necrosis Factor ◽  
Necrosis Factor

scholarly journals Hemorrhagic tumor necrosis during a pilot trial of tumor necrosis factor-alpha and anti-GD3 ganglioside monoclonal antibody in patients with metastatic melanoma

Blood ◽  
1994 ◽  
Vol 83 (1) ◽  
pp. 56-64 ◽  
Author(s):  
LM Minasian ◽  
TP Szatrowski ◽  
M Rosenblum ◽  
T Steffens ◽  
ME Morrison ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Tumor Necrosis Factor ◽  
Metastatic Melanoma ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Tnf Alpha ◽  
Necrosis Factor Alpha ◽  
Gd3 Ganglioside ◽  
Factor Alpha ◽  
Necrosis Factor

Abstract Hemorrhagic tumor necrosis is an inflammatory event that leads to selective destruction of malignant tissues, with both potentially toxic and beneficial consequences. A pilot clinical trial was undertaken combining tumor necrosis factor-alpha (TNF-alpha) with the monoclonal antibody R24 (MoAb R24) against GD3 ganglioside in patients with metastatic melanoma. Patients received MoAb R24 to recruit leukocytes to the tumor followed by low doses of recombinant TNF-alpha to activate leukocytes. Eight patients were treated and seven patients had mild toxicity. One patient with extensive metastatic melanoma developed tumor lysis syndrome within hours after treatment with almost complete necrosis of bulky tumors in multiple visceral sites. To our knowledge, this is the first documented case of hemorrhagic tumor necrosis in a patient with metastatic cancer in multiple visceral sites.

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