Interphase epichromatin: last refuge for the 30-nm chromatin fiber?

Chromosoma ◽  
2021 ◽  
Author(s):  
Peng Xu ◽  
Julia Mahamid ◽  
Marco Dombrowski ◽  
Wolfgang Baumeister ◽  
Ada L. Olins ◽  
...  
Keyword(s):  
Chromatin Fiber

scholarly journals Nucleosome interactions in chromatin: Fiber stiffening and hairpin formation

2004 ◽  
Vol 70 (1) ◽  
Author(s):  
Boris Mergell ◽  
Ralf Everaers ◽  
Helmut Schiessel
Keyword(s):  
Chromatin Fiber ◽  
Hairpin Formation

To the 30-nm chromatin fiber and beyond

2004 ◽  
Vol 1677 (1-3) ◽  
pp. 12-23 ◽  
Author(s):  
Nicholas L Adkins ◽  
Meagan Watts ◽  
Philippe T Georgel
Keyword(s):  
Chromatin Fiber

Nucleosome and chromatin fiber dynamics

2005 ◽  
Vol 15 (2) ◽  
pp. 188-196 ◽  
Author(s):  
Karolin Luger ◽  
Jeffrey C Hansen
Keyword(s):  
Chromatin Fiber ◽  
Fiber Dynamics

scholarly journals Local chromatin fiber folding represses transcription and loop extrusion in quiescent cells

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Sarah G Swygert ◽  
Dejun Lin ◽  
Stephanie Portillo-Ledesma ◽  
Po-Yen Lin ◽  
Dakota R Hunt ◽  
...  
Keyword(s):  
Chromatin Fiber ◽  
State Transitions ◽  
Chromatin Domain ◽  
Global Changes ◽  
Histone H4 ◽  
Mitotic Chromosomes ◽  
Quiescent Cells ◽  
Genome Wide ◽  
Dividing Cells ◽  
The Relationship

A longstanding hypothesis is that chromatin fiber folding mediated by interactions between nearby nucleosomes represses transcription. However, it has been difficult to determine the relationship between local chromatin fiber compaction and transcription in cells. Further, global changes in fiber diameters have not been observed, even between interphase and mitotic chromosomes. We show that an increase in the range of local inter-nucleosomal contacts in quiescent yeast drives the compaction of chromatin fibers genome-wide. Unlike actively dividing cells, inter-nucleosomal interactions in quiescent cells require a basic patch in the histone H4 tail. This quiescence-specific fiber folding globally represses transcription and inhibits chromatin loop extrusion by condensin. These results reveal that global changes in chromatin fiber compaction can occur during cell state transitions, and establish physiological roles for local chromatin fiber folding in regulating transcription and chromatin domain formation.

scholarly journals Evaluation of origin of driving force for loop formation in a chromatin fiber

2020 ◽  
Author(s):  
Hiroshi Yokota ◽  
Masashi Tachikawa
Keyword(s):  
Driving Force ◽  
Chromatin Fiber ◽  
Technical Error ◽  
Loop Formation ◽  
Link Type

This article has been withdrawn by bioRxiv owing to a technical error that created a duplicate posting of this manuscript. Please see doi: https://doi.org/10.1101/2020.06.24.168757 to access the preprint.

Sign in / Sign up

Export Citation Format

Share Document