Spinal cord lesions are frequently asymptomatic in relapsing–remitting multiple sclerosis: a retrospective MRI survey

2019 ◽  
Vol 266 (12) ◽  
pp. 3031-3037 ◽  
Author(s):  
Franco Granella ◽  
Elena Tsantes ◽  
Stefania Graziuso ◽  
Veronica Bazzurri ◽  
Girolamo Crisi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Spinal Cord Lesions ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis

Early diffuse demyelinating lesion in the cervical spinal cord predicts a worse prognosis in relapsing—remitting multiple sclerosis

2010 ◽  
Vol 16 (8) ◽  
pp. 935-941 ◽  
Author(s):  
F. Coret ◽  
I. Bosca ◽  
L. Landete ◽  
MJ Magraner ◽  
A. Navarré ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Cervical Spinal Cord ◽  
Long Term Outcome ◽  
Relapsing Remitting ◽  
Group A ◽  
Remitting Multiple Sclerosis ◽  
Group B ◽  
Relapsing Remitting Multiple Sclerosis ◽  
Worse Prognosis

Objective: To study the long-term outcome and persistence of two patterns of cervical spinal cord abnormality in early relapsing—remitting multiple sclerosis (RRMS). Methods: RRMS patients with a spinal cord MRI performed during the first 3 years of the disease, a control MRI 5 years later and who have been followed up at least 10 years were included. Patients were grouped according the T2 spinal cord MRI into: (A) nodular pattern, if one or more focal lesions were present; and (B) diffuse pattern, defined as a poorly demarcated high signal area. The end point was defined as the time to reach an Expanded Disability Status Score (EDSS) of 4.0. Results: Twenty-five patients were included; 12 in group A and 13 in group B. Three patients in group A and 9 in group B reached EDSS 4, in a mean time of 11 years in group A and 7 years in group B (log rank 10.3, p = 0.001). Multivariate Cox regression analysis assessing the risk of EDSS 4.0 including sex, age, number of relapses in the first 2 years, number of T2 brain lesions and spinal cord pattern showed higher risk for the diffuse pattern (hazard ratio 7.2, 95% confidence interval 1.4—36.4). Control MRI showed the persistence of the diffuse pattern in all patients, and the development of diffuse pattern in two patients with basal nodular lesions. Conclusions: The diffuse abnormality in cervical spinal cord at the beginning of the disease is persistent and predicts a worse prognosis in RRMS patients.

scholarly journals Sodium in the Relapsing–Remitting Multiple Sclerosis Spinal Cord: Increased Concentrations and Associations With Microstructural Tissue Anisotropy

2020 ◽  
Vol 52 (5) ◽  
pp. 1429-1438 ◽  
Author(s):  
Bhavana S. Solanky ◽  
Ferran Prados ◽  
Carmen Tur ◽  
Marios C. Yiannakas ◽  
Baris Kanber ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Relapsing Remitting ◽  
Tissue Anisotropy ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis

scholarly journals Brain and spinal cord MRI lesions in primary progressive vs. relapsing-remitting multiple sclerosis

2018 ◽  
Vol 12 ◽  
pp. 42-46 ◽  
Author(s):  
Akram Dastagir ◽  
Brian C. Healy ◽  
Alicia S. Chua ◽  
Tanuja Chitnis ◽  
Howard L. Weiner ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Primary Progressive ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis ◽  
Brain And Spinal Cord

scholarly journals The Effect of Glatiramer Acetate on Spinal Cord Volume in Relapsing-Remitting Multiple Sclerosis

2016 ◽  
Vol 27 (1) ◽  
pp. 33-36 ◽  
Author(s):  
Tarun Singhal ◽  
Shahamat Tauhid ◽  
Shelley Hurwitz ◽  
Mohit Neema ◽  
Rohit Bakshi
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Glatiramer Acetate ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis ◽  
Spinal Cord Volume

Serial gadolinium-enhanced MRI of the brain and spinal cord in early relapsing-remitting multiple sclerosis

Neurology ◽  
1996 ◽  
Vol 46 (2) ◽  
pp. 373-378 ◽  
Author(s):  
J. W. Thorpe ◽  
D. Kidd ◽  
I. F. Moseley ◽  
B. E. Kendall ◽  
A. J. Thompson ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Enhanced Mri ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis ◽  
Brain And Spinal Cord ◽  
The Brain
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