The course of cervical spinal cord atrophy rate and its relationship with NEDA in relapsing remitting multiple sclerosis

2021 ◽  
Author(s):  
Vedat Cilingir ◽  
Hüseyin Akdeniz
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Cervical Spinal Cord ◽  
Spinal Cord Atrophy ◽  
Atrophy Rate ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis

Early diffuse demyelinating lesion in the cervical spinal cord predicts a worse prognosis in relapsing—remitting multiple sclerosis

2010 ◽  
Vol 16 (8) ◽  
pp. 935-941 ◽  
Author(s):  
F. Coret ◽  
I. Bosca ◽  
L. Landete ◽  
MJ Magraner ◽  
A. Navarré ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Cervical Spinal Cord ◽  
Long Term Outcome ◽  
Relapsing Remitting ◽  
Group A ◽  
Remitting Multiple Sclerosis ◽  
Group B ◽  
Relapsing Remitting Multiple Sclerosis ◽  
Worse Prognosis

Objective: To study the long-term outcome and persistence of two patterns of cervical spinal cord abnormality in early relapsing—remitting multiple sclerosis (RRMS). Methods: RRMS patients with a spinal cord MRI performed during the first 3 years of the disease, a control MRI 5 years later and who have been followed up at least 10 years were included. Patients were grouped according the T2 spinal cord MRI into: (A) nodular pattern, if one or more focal lesions were present; and (B) diffuse pattern, defined as a poorly demarcated high signal area. The end point was defined as the time to reach an Expanded Disability Status Score (EDSS) of 4.0. Results: Twenty-five patients were included; 12 in group A and 13 in group B. Three patients in group A and 9 in group B reached EDSS 4, in a mean time of 11 years in group A and 7 years in group B (log rank 10.3, p = 0.001). Multivariate Cox regression analysis assessing the risk of EDSS 4.0 including sex, age, number of relapses in the first 2 years, number of T2 brain lesions and spinal cord pattern showed higher risk for the diffuse pattern (hazard ratio 7.2, 95% confidence interval 1.4—36.4). Control MRI showed the persistence of the diffuse pattern in all patients, and the development of diffuse pattern in two patients with basal nodular lesions. Conclusions: The diffuse abnormality in cervical spinal cord at the beginning of the disease is persistent and predicts a worse prognosis in RRMS patients.

Spinal cord lesions are frequently asymptomatic in relapsing–remitting multiple sclerosis: a retrospective MRI survey

2019 ◽  
Vol 266 (12) ◽  
pp. 3031-3037 ◽  
Author(s):  
Franco Granella ◽  
Elena Tsantes ◽  
Stefania Graziuso ◽  
Veronica Bazzurri ◽  
Girolamo Crisi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Spinal Cord Lesions ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis

scholarly journals Sodium in the Relapsing–Remitting Multiple Sclerosis Spinal Cord: Increased Concentrations and Associations With Microstructural Tissue Anisotropy

2020 ◽  
Vol 52 (5) ◽  
pp. 1429-1438 ◽  
Author(s):  
Bhavana S. Solanky ◽  
Ferran Prados ◽  
Carmen Tur ◽  
Marios C. Yiannakas ◽  
Baris Kanber ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Relapsing Remitting ◽  
Tissue Anisotropy ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis

scholarly journals Brain and spinal cord MRI lesions in primary progressive vs. relapsing-remitting multiple sclerosis

2018 ◽  
Vol 12 ◽  
pp. 42-46 ◽  
Author(s):  
Akram Dastagir ◽  
Brian C. Healy ◽  
Alicia S. Chua ◽  
Tanuja Chitnis ◽  
Howard L. Weiner ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Primary Progressive ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis ◽  
Brain And Spinal Cord

Focal and diffuse cervical spinal cord damage in patients with early relapsing–remitting MS: A multicentre magnetisation transfer ratio study

2018 ◽  
Vol 25 (8) ◽  
pp. 1113-1123 ◽  
Author(s):  
Benoît Combès ◽  
Anne Kerbrat ◽  
Jean Christophe Ferré ◽  
Virginie Callot ◽  
Josefina Maranzano ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Cervical Spinal Cord ◽  
Magnetisation Transfer ◽  
Phase Sensitive Inversion Recovery ◽  
Magnetisation Transfer Ratio ◽  
Transfer Ratio ◽  
Relapsing Remitting ◽  
Phase Sensitive ◽  
Relapsing Remitting Multiple Sclerosis

Background: Studies including patients with well-established multiple sclerosis (MS) have shown a significant and disability-related reduction in the cervical spinal cord (SC) magnetisation transfer ratio (MTR). Objectives: The objectives are to (1) assess whether MTR reduction is already measurable in the SC of patients with early relapsing–remitting multiple sclerosis (RRMS) and (2) describe its spatial distribution. Methods: We included 60 patients with RRMS <12  months and 34 age-matched controls at five centres. Axial T2*w, sagittal T2w, sagittal phase-sensitive inversion recovery (PSIR), 3DT1w, and axial magnetisation transfer (MT) images were acquired from C1 to C7. Lesions were manually labelled and mean MTR values computed both for the whole SC and for normal-appearing SC in different regions of interest. Results: Mean whole SC MTR was significantly lower in patients than controls (33.7 vs 34.9  pu, p  =  0.00005), even after excluding lesions (33.9  pu, p  =  0.0003). We observed a greater mean reduction in MTR for vertebral levels displaying the highest lesion loads (C2–C4). In the axial plane, we observed a greater mean MTR reduction at the SC periphery and barycentre. Conclusion: Cervical SC tissue damage measured using MTR is not restricted to macroscopic lesions in patients with early RRMS and is not homogeneously distributed.

scholarly journals The Effect of Glatiramer Acetate on Spinal Cord Volume in Relapsing-Remitting Multiple Sclerosis

2016 ◽  
Vol 27 (1) ◽  
pp. 33-36 ◽  
Author(s):  
Tarun Singhal ◽  
Shahamat Tauhid ◽  
Shelley Hurwitz ◽  
Mohit Neema ◽  
Rohit Bakshi
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Glatiramer Acetate ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis ◽  
Spinal Cord Volume

Serial gadolinium-enhanced MRI of the brain and spinal cord in early relapsing-remitting multiple sclerosis

Neurology ◽  
1996 ◽  
Vol 46 (2) ◽  
pp. 373-378 ◽  
Author(s):  
J. W. Thorpe ◽  
D. Kidd ◽  
I. F. Moseley ◽  
B. E. Kendall ◽  
A. J. Thompson ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Enhanced Mri ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis ◽  
Brain And Spinal Cord ◽  
The Brain
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