scholarly journals Vascular risk factors, white matter lesions and cognitive impairment in Parkinson’s disease: the PACOS longitudinal study

2020 ◽  
Author(s):  
Alessandra Nicoletti ◽  
Antonina Luca ◽  
Roberta Baschi ◽  
Calogero Edoardo Cicero ◽  
Giovanni Mostile ◽  
...  
Keyword(s):  
Risk Factors ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Longitudinal Study ◽  
White Matter ◽  
White Matter Lesions ◽  
Vascular Risk Factors ◽  
Vascular Risk

Vascular risk factors do not contribute to motor and cognitive impairment in Parkinson's disease

2010 ◽  
Vol 16 (1) ◽  
pp. 73-74 ◽  
Author(s):  
J. Sławek ◽  
D. Wieczorek ◽  
M. Derejko ◽  
M. Dubaniewicz ◽  
B. Brockhuis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Vascular Risk Factors ◽  
Vascular Risk

scholarly journals Modifiable vascular risk factors, white matter disease and cognition in early Parkinson's disease

2018 ◽  
Vol 26 (2) ◽  
pp. 246-e18 ◽  
Author(s):  
L. M. Chahine ◽  
C. Dos Santos ◽  
M. Fullard ◽  
C. Scordia ◽  
D. Weintraub ◽  
...  
Keyword(s):  
Risk Factors ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
Vascular Risk Factors ◽  
White Matter Disease ◽  
Vascular Risk ◽  
Early Parkinson’S Disease

Treatment response in late-onset depression: relationship to neuropsychological, neuroradiological and vascular risk factors

2004 ◽  
Vol 34 (1) ◽  
pp. 125-136 ◽  
Author(s):  
R. BALDWIN ◽  
S. JEFFRIES ◽  
A. JACKSON ◽  
C. SUTCLIFFE ◽  
N. THACKER ◽  
...  
Keyword(s):  
Risk Factors ◽  
Executive Function ◽  
White Matter ◽  
Depressive Disorder ◽  
Late Onset ◽  
White Matter Lesions ◽  
Vascular Risk Factors ◽  
Group Differences ◽  
Vascular Risk ◽  
Control Subjects

Background. Late-onset depressive disorder is associated with white matter lesions and neuropsychological deficits that in some studies are linked to a poorer outcome for depression. Some white matter lesions may be vascular in origin. This study investigated the relationship between response or non-response to antidepressant monotherapy and neuropsychological function, structural brain measures and vascular factors.Method. This was a case–control study. Fifty patients with late-onset major depressive disorder (29 who were responders to antidepressant monotherapy and 21 who were not) were compared with 35 non-depressed control subjects. Measures included assessment of vascular risk factors, neuropsychological testing and a magnetic resonance imaging (MRI) scan.Results. After adjustment for depressed mood and medication at evaluation, both patient groups had significantly more impairment compared to control subjects on verbal learning tasks involving immediate or delayed recall. Patients who did not respond to antidepressant monotherapy had significantly poorer performance than controls on tests involving visuospatial ability, language, word recognition and tests of executive function, whereas there were no differences between control subjects and responders. On two tests of executive function (verbal fluency and the Stroop test) non-responders scored significantly worse than responders. There were no significant group differences on MRI measures of atrophy or of white matter lesions apart from a higher periventricular hyperintensity score in non-responders compared to controls. There were no group differences on measures of vascular disease.Conclusion. The results lend support to the emerging evidence that resistance to treatment in late-onset depression may be associated with impaired executive function. Subtle cerebrovascular mechanisms may be involved.

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