Three-dimensional choroidal vascularity index in acute central serous chorioretinopathy using swept-source optical coherence tomography

AbstractThe purpose of the study was to evaluate the retinal blood flow in patients with acute central serous chorioretinopathy (CSC) over an observational period of 1 month using swept-source optical coherence tomography (SS-OCTA), focusing especially on changes in the area of subretinal fluid (A-SRF). We correlated these findings with conventional indocyanine green angiography (ICGA). ICGA and SS-OCTA images were collected and analyzed of 12 eyes of 12 patients. The A-SRF was annotated and a qualitative analysis of choriocapillaris, the vessel density (VD) and perfusion density (PD) of the retinal superficial capillary plexus (SCP) and the deep capillary plexus (DCP) was performed in A-SRF and the unaffected remaining area (RA). The VD and PD in the DCP were statistically significantly lower in A-SRF than in the RA at baseline. (VD: p = 0.014; PD: p = 0.036). After 1 month, there was a statistically significant difference in the VD and PD of the DCP (VD: p = 0.015; PD: p = 0.014), and for the PD of the SCP between the A-SRF and the RA (p = 0.015), with lower values in the A-SRF. We found low perfused areas in choriocapillaris corresponding to hypofluorescent areas on ICGA. In conclusion there is a difference in VD and VD of the DCP in the area of SRF in acute CSC. These alterations may lead to a chronic change in the microvasculature and potentially to morphological changes.

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Diagnostic Function of 3D Optical Coherence Tomography Multimode Images in Diagnosis of Acute Central Serous Chorioretinopathy

10.21203/rs.3.rs-134896/v1 ◽

2020 ◽

Author(s):

Gui-ling Zhao ◽

Rui-zhuang Li ◽

Yan-hua Pang ◽

Xiu-qin Wang ◽

Jin-fen Wei ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Central Serous Chorioretinopathy ◽

High Speed ◽

Three Dimensional ◽

Internal Limiting Membrane ◽

Diagnostic Value ◽

Optical Coherence ◽

Three Dimension ◽

Acute Central Serous Chorioretinopathy ◽

B Scan Images

Abstract Background: Spectral-Domain Optical coherence tomography (SD-OCT) provides non-invasive, high speed, high resolution, three-dimensional cross-section imaging of macula. This study was aimed to investigate the diagnostic value of multimodal imaging technique of three-dimension (3D) optical coherence tomography (OCT) (3D-OCT) for diagnosis and characterizing of acute central serous chorioretinopathy (CSC). Methods: The 3D-OCT examinations of 82 cases of acute CSC were performed on the macular area, and the image characteristics were analyzed. Our study included a total of 87 eyes from 82 cases of CSC patients, 67 males and 15 females, aged 27 to 56 years, mean age 42.89±7.80 years old.Results: According to B-scan images, 87 (100%) eyes had ERD, 38 (44%) eyes had bulge of RPE, 36 (41%) eyes had PED, 8 (9%) eyes had membrane -like structure, 2 (2%) eyes had subretinal dot-like precipitates, 1 (1%) eyes had focal choroidal excavation (FCE), and 1 (1%) eye had fluctuation of internal limiting membrane (FI). In ILM-RPE thickness map, all eyes had a round or round like regular uniform domes. Total of 57 (66%) domes were limited in exam area and 30 (44%) domes beyond the scope of this examination and only part of the dome could be observed. In the Shadowgram image, all eyes had a round or round like black figure that correspond with domes In ILM-RPE thickness map. In RPE surface, 76(87%) eyes had a shallow plate depression, 71(82%) had small focal uplift and 1 (1%) eye had a focal concave.Conclusions: In OCT ILM-RPE thickness map, Shadowgram, and RPE surface, acute CSC had special images and can be helpful for diagnosis and difference diagnosis.Trial registration: Not applicable.

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Three-dimensional segmentation and depth-encoded visualization of choroidal vasculature using swept-source optical coherence tomography

Experimental Biology and Medicine ◽

10.1177/15353702211028540 ◽

2021 ◽

pp. 153537022110285

Author(s):

Hao Zhou ◽

Tommaso Bacci ◽

K Bailey Freund ◽

Ruikang K Wang

Keyword(s):

Optical Coherence Tomography ◽

Three Dimensional ◽

Age Related Macular Degeneration ◽

Optical Coherence ◽

Full Thickness ◽

Swept Source ◽

Automated Method ◽

Choroidal Imaging ◽

Choroidal Vasculature ◽

Choroidal Vessels

The choroid provides nutritional support for the retinal pigment epithelium and photoreceptors. Choroidal dysfunction plays a major role in several of the most important causes of vision loss including age-related macular degeneration, myopic degeneration, and pachychoroid diseases such as central serous chorioretinopathy and polypoidal choroidal vasculopathy. We describe an imaging technique using depth-resolved swept-source optical coherence tomography (SS-OCT) that provides full-thickness three-dimensional (3D) visualization of choroidal anatomy including topographical features of individual vessels. Enrolled subjects with different clinical manifestations within the pachychoroid disease spectrum underwent 15 mm × 9 mm volume scans centered on the fovea. A fully automated method segmented the choroidal vessels using their hyporeflective lumens. Binarized choroidal vessels were rendered in a 3D viewer as a vascular network within a choroidal slab. The network of choroidal vessels was color depth-encoded with a reference to the Bruch’s membrane segmentation. Topographical features of the choroidal vasculature were characterized and compared with choroidal imaging obtained with indocyanine green angiography (ICGA) from the same subject. The en face SS-OCT projections of the larger choroid vessels closely resembled to that obtained with ICGA, with the automated SS-OCT approach proving additional depth-encoded 3D information. In 16 eyes with pachychoroid disease, the SS-OCT approach added clinically relevant structural details, including choroidal thickness and vessel depth, which the ICGA studies could not provide. Our technique appears to advance the in vivo visualization of the full-thickness choroid, successfully reveals the topographical features of choroidal vasculature, and shows potential for further quantitative analysis when compared with other choroidal imaging techniques. This improved visualization of choroidal vasculature and its 3D structure should provide an insight into choroid-related disease mechanisms as well as their responses to treatment.

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