The effects of creatine supplementation on muscular performance and body composition responses to short-term resistance training overreaching

IntroductionCreatine supplementation has consistently been demonstrated to augment adaptations in body composition, muscle strength and physical function in a variety of apparently healthy older adults and clinical populations. The effects of creatine supplementation and resistance training in individuals with cancer have yet to be investigated. This study aims to examine the effects of creatine supplementation in conjunction with resistance training on body composition, muscle strength and physical function in prostate cancer patients undergoing androgen deprivation therapy.Methods and analysisThis is a randomised, double-blind, placebo-controlled trial designed to examine the effects of creatine supplementation in addition to resistance training in patients with prostate cancer receiving androgen deprivation therapy. Both supplement and placebo groups will receive a 12-week supervised exercise programme comprising resistance training undertaken three times per week. The primary endpoint (fat-free mass) and secondary endpoints (fat mass, per cent body fat, physical fitness, quality of life and blood biomarkers) will be assessed at baseline and immediately following the intervention.Ethics and disseminationThe Human Research Ethics Committee of Edith Cowan University approved this study (ID: 22243 FAIRMAN). If the results of this trial demonstrate that creatine supplementation can augment beneficial adaptations of body composition, physical function and/or psychosocial outcomes to resistance training, this study will provide effect sizes that will inform the design of subsequent definitive randomised controlled trials. The results of this study will be published in peer-reviewed journals and presented at various national and international conferences.Trial registration numberACTRN12619000099123

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Short-term creatine supplementation does not alter the hormonal response to resistance training

Medicine & Science in Sports & Exercise ◽

10.1097/00005768-200103000-00018 ◽

2001 ◽

Vol 33 (3) ◽

pp. 449-453 ◽

Cited By ~ 18

Author(s):

BERT OP ???T EIJNDE ◽

PETER HESPEL

Keyword(s):

Resistance Training ◽

Creatine Supplementation ◽

Hormonal Response ◽

Short Term

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THE EFFECTS OF CREATINE SUPPLEMENTATION ON RESTING SERUM HORMONAL CONCENTRATIONS DURING SHORT-TERM RESISTANCE TRAINING OVERREACHING

Medicine & Science in Sports & Exercise ◽

10.1097/00005768-200105001-01142 ◽

2001 ◽

Vol 33 (5) ◽

pp. S203 ◽

Cited By ~ 2

Author(s):

D N. French ◽

J S. Volek ◽

N A. Ratamess ◽

S A. Mazzetti ◽

M R. Rubin ◽

...

Keyword(s):

Resistance Training ◽

Creatine Supplementation ◽

Short Term

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Four Weeks of Time-Restricted Feeding Combined with Resistance Training Does Not Differentially Influence Measures of Body Composition, Muscle Performance, Resting Energy Expenditure, and Blood Biomarkers

Nutrients ◽

10.3390/nu12041126 ◽

2020 ◽

Vol 12 (4) ◽

pp. 1126 ◽

Cited By ~ 1

Author(s):

Matthew T. Stratton ◽

Grant M. Tinsley ◽

Michaela G. Alesi ◽

Garrett M. Hester ◽

Alex A. Olmos ◽

...

Keyword(s):

Body Composition ◽

Resistance Training ◽

Energy Expenditure ◽

Resting Energy Expenditure ◽

Muscle Performance ◽

Restricted Feeding ◽

Blood Biomarkers ◽

Muscular Performance ◽

Caloric Deficit ◽

Resting Energy

Recently, interest in time-restricted feeding (TRF) has increased from reports highlighting improvements in body composition and muscular performance measures. Twenty-six recreationally active males were randomly assigned to either TRF (n = 13; ~22.9 years; 82.0 kg; 178.1 cm; 8 h eating window, 25% caloric deficit, 1.8 g/kg/day protein) or normal diet (ND; n = 13; ~22.5 years; 83.3 kg; 177.5 cm; normal meal pattern; 25% caloric deficit, 1.8 g/kg/day protein) groups. Participants underwent 4-weeks of supervised full body resistance training. Changes in body composition (fat mass (FM), fat free mass (FFM), and body fat percentage (BF%)), skeletal muscle cross sectional area (CSA) and muscle thickness (MT) of the vastus lateralis (VL), rectus femoris, (RF), and biceps brachii (BB) muscles, resting energy expenditure (REE), muscular performance, blood biomarkers, and psychometric parameters were assessed. Significant (p < 0.05) decreases were noted in BM, FM, BF%, testosterone, adiponectin, and REE, along with significant increases in BP1RM, LP1RM, VJHT, VJPP, VLCSA, BBCSA, and BBMT in both groups. Plasma cortisol levels were significantly elevated at post (p = 0.018) only in ND. Additionally, FFM was maintained equally between groups. Thus, a TRF style of eating does not enhance reductions in FM over caloric restriction alone during a 4-week hypocaloric diet.

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