Hormones increase mRNA of cyclic-nucleotide-gated cation channels in airway epithelia

2000 ◽  
Vol 441 (1) ◽  
pp. 69-77 ◽  
Author(s):  
W. Qiu ◽  
A. Laheri ◽  
Steve Leung ◽  
S.E. Guggino
Keyword(s):  
Cyclic Nucleotide ◽  
Cation Channels ◽  
Airway Epithelia

Cyclic Nucleotide-Gated Cation Channels

1996 ◽  
Vol 6 (8) ◽  
pp. 274-280 ◽  
Author(s):  
Martin Biel ◽  
Xiangang Zong ◽  
Franz Hofmann
Keyword(s):  
Cyclic Nucleotide ◽  
Cation Channels

Expression of hyperpolarization-activated cyclic nucleotide-gated cation channels in rat dorsal root ganglion neurons innervating urinary bladder

2006 ◽  
Vol 1119 (1) ◽  
pp. 115-123 ◽  
Author(s):  
Hiroko Matsuyoshi ◽  
Noriyuki Masuda ◽  
Michael B. Chancellor ◽  
Vickie L. Erickson ◽  
Yoshihiko Hirao ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Dorsal Root Ganglion ◽  
Cyclic Nucleotide ◽  
Dorsal Root ◽  
Dorsal Root Ganglion Neurons ◽  
Cation Channels ◽  
Ganglion Neurons

scholarly journals Cyclic Nucleotide-Gated Ion Channels

2002 ◽  
Vol 82 (3) ◽  
pp. 769-824 ◽  
Author(s):  
U. Benjamin Kaupp ◽  
Reinhard Seifert
Keyword(s):  
Ion Channels ◽  
Sensory Neurons ◽  
Cyclic Nucleotide ◽  
Cation Channels ◽  
Voltage Gated ◽  
Nonselective Cation Channels ◽  
Retinal Photoreceptors ◽  
Cng Channel ◽  
B Subunits ◽  
Gated Ion Channels

Cyclic nucleotide-gated (CNG) channels are nonselective cation channels first identified in retinal photoreceptors and olfactory sensory neurons (OSNs). They are opened by the direct binding of cyclic nucleotides, cAMP and cGMP. Although their activity shows very little voltage dependence, CNG channels belong to the superfamily of voltage-gated ion channels. Like their cousins the voltage-gated K+ channels, CNG channels form heterotetrameric complexes consisting of two or three different types of subunits. Six different genes encoding CNG channels, four A subunits (A1 to A4) and two B subunits (B1 and B3), give rise to three different channels in rod and cone photoreceptors and in OSNs. Important functional features of these channels, i.e., ligand sensitivity and selectivity, ion permeation, and gating, are determined by the subunit composition of the respective channel complex. The function of CNG channels has been firmly established in retinal photoreceptors and in OSNs. Studies on their presence in other sensory and nonsensory cells have produced mixed results, and their purported roles in neuronal pathfinding or synaptic plasticity are not as well understood as their role in sensory neurons. Similarly, the function of invertebrate homologs found in Caenorhabditis elegans, Drosophila,and Limulus is largely unknown, except for two subunits of C. elegans that play a role in chemosensation. CNG channels are nonselective cation channels that do not discriminate well between alkali ions and even pass divalent cations, in particular Ca2+. Ca2+ entry through CNG channels is important for both excitation and adaptation of sensory cells. CNG channel activity is modulated by Ca2+/calmodulin and by phosphorylation. Other factors may also be involved in channel regulation. Mutations in CNG channel genes give rise to retinal degeneration and color blindness. In particular, mutations in the A and B subunits of the CNG channel expressed in human cones cause various forms of complete and incomplete achromatopsia.

scholarly journals A novel role for cyclic nucleotide-gated cation channels in lung liquid homeostasis in sheep

1999 ◽  
Vol 520 (1) ◽  
pp. 255-260 ◽  
Author(s):  
R. W. J. Junor ◽  
A. R. Benjamin ◽  
D. Alexandrou ◽  
S. E. Guggino ◽  
D. V. Walters
Keyword(s):  
Cyclic Nucleotide ◽  
Cation Channels ◽  
Lung Liquid

Cyclic Nucleotide-Activated Currents in Cultured Olfactory Receptor Neurons of the Hawkmoth Manduca sexta

2008 ◽  
Vol 100 (5) ◽  
pp. 2866-2877 ◽  
Author(s):  
Steffi Krannich ◽  
Monika Stengl
Keyword(s):  
Manduca Sexta ◽  
Cyclic Nucleotide ◽  
Olfactory Receptor ◽  
Low Voltage ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Guanosine Monophosphate ◽  
Olfactory Receptor Neurons ◽  
Cation Channels ◽  
Receptor Neurons

Moth pheromones cause rises in intracellular Ca2+ concentrations that activate Ca2+-dependent cation channels in antennal olfactory receptor neurons. In addition, mechanisms of adaptation and sensitization depend on changes in cyclic nucleotide concentrations. Here, cyclic nucleotide-activated currents in cultured olfactory receptor neurons of the moth Manduca sexta are described, which share properties with currents through vertebrate cyclic nucleotide-gated channels. The cyclic nucleotide-activated currents of M. sexta carried Ca2+ and monovalent cations. They were directly activated by cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), modulated by Ca2+/calmodulin, and inhibited by lanthanum. M. sexta cyclic nucleotide-activated currents developed in an all-or-none manner, which suggests that the underlying channels are coupled and act coordinately. At least one cAMP- and two cGMP-activated nonselective cation currents could be distinguished. Compared with the cAMP-activated current, both cGMP-activated currents appeared to conduct more Ca2+ and showed a stronger down-regulation by Ca2+/calmodulin-dependent negative feedback. Furthermore, both cGMP-activated currents differed in their Ca2+-dependent inhibition. Thus M. sexta olfactory receptor neurons, like vertebrate sensory neurons, appear to express nonselective cyclic nucleotide-activated cation channels with different subunit compositions. Besides the nonselective cyclic nucleotide-activated cation currents, olfactory receptor neurons express a cAMP-dependent current. This current resembled a protein kinase-modulated low-voltage–activated Ca2+ current.

scholarly journals Genetic Analysis of Hyperpolarization-Activated Cyclic Nucleotide-Gated Cation Channels in Sudden Unexpected Death in Epilepsy Cases

2011 ◽  
Vol 21 (6) ◽  
pp. 692-698 ◽  
Author(s):  
Emily Tu ◽  
Louise Waterhouse ◽  
Johan Duflou ◽  
Richard D. Bagnall ◽  
Christopher Semsarian
Keyword(s):  
Genetic Analysis ◽  
Cyclic Nucleotide ◽  
Sudden Unexpected Death ◽  
Cation Channels ◽  
Unexpected Death
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