Analgesic effect of ivabradine against inflammatory pain mediated by hyperpolarization-activated cyclic nucleotide-gated cation channels expressed on primary afferent terminals in spinal dorsal horn

Pain ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Nobuko Ohashi ◽  
Daisuke Uta ◽  
Masayuki Ohashi ◽  
Hiroshi Baba
Keyword(s):  
Dorsal Horn ◽  
Cyclic Nucleotide ◽  
Inflammatory Pain ◽  
Analgesic Effect ◽  
Spinal Dorsal Horn ◽  
Cation Channels ◽  
Primary Afferent ◽  
Spinal Dorsal ◽  
Afferent Terminals

SNAP25/syntaxin4/VAMP2/Munc18-1 Complexes in Spinal Dorsal Horn Contributed to Inflammatory Pain

Neuroscience ◽  
2020 ◽  
Vol 429 ◽  
pp. 203-212 ◽  
Author(s):  
Xing-Lian Duan ◽  
Zhen Guo ◽  
Yong-Tao He ◽  
Yin-Xia Li ◽  
Yan-Ni Liu ◽  
...  
Keyword(s):  
Dorsal Horn ◽  
Inflammatory Pain ◽  
Spinal Dorsal Horn ◽  
Spinal Dorsal

scholarly journals Prior perineural or neonatal treatment with capsaicin does not alter the development of spinal microgliosis induced by peripheral nerve injury

2020 ◽  
Author(s):  
Ivett Dorina Szeredi ◽  
Gábor Jancsó ◽  
Orsolya Oszlács ◽  
Péter Sántha
Keyword(s):  
Peripheral Nerve ◽  
Dorsal Horn ◽  
Nerve Injury ◽  
Peripheral Nerve Injury ◽  
Spinal Dorsal Horn ◽  
Primary Afferents ◽  
Primary Afferent ◽  
Spinal Dorsal ◽  
C Fiber ◽  
Spinal Afferents

Abstract Peripheral nerve injury is associated with spinal microgliosis which plays a pivotal role in the development of neuropathic pain behavior. Several agents of primary afferent origin causing the microglial reaction have been identified, but the type(s) of primary afferents that release these mediators are still unclear. In this study, specific labeling of C-fiber spinal afferents by lectin histochemistry and selective chemodenervation by capsaicin were applied to identify the type(s) of primary afferents involved in the microglial response. Comparative quantitative morphometric evaluation of the microglial reaction in central projection territories of intact and injured peripheral nerves in the superficial (laminae I and II) and deep (laminae III and IV) spinal dorsal horn revealed a significant, about three-fold increase in microglial density after transection of the sciatic or the saphenous nerve. Prior perineural treatment of these nerves with capsaicin, resulting in a selective defunctionalization of C-fiber afferent fibers failed to affect spinal microgliosis. Similarly, peripheral nerve injury-induced increase in microglial density was unaffected in rats treated neonatally with capsaicin known to result in a near-total loss of C-fiber dorsal root fibers. Perineural treatment with capsaicin per se did not evoke a significant increase in microglial density. These observations indicate that injury-induced spinal microgliosis may be attributed to phenotypic changes in injured myelinated primary afferent neurons, whereas the contribution of C-fiber primary sensory neurons to this neuroimmune response is negligible. Spinal myelinated primary afferents may play a hitherto unrecognized role in regulation of neuroimmune and perisynaptic microenvironments of the spinal dorsal horn.

Reorganization of the primary afferent termination in the rat spinal dorsal horn during post-natal development

1999 ◽  
Vol 113 (1-2) ◽  
pp. 29-36 ◽  
Author(s):  
Jin-Soo Park ◽  
Terumasa Nakatsuka ◽  
Kensei Nagata ◽  
Hideho Higashi ◽  
Megumu Yoshimura
Keyword(s):  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Primary Afferent ◽  
Spinal Dorsal

Ht31 peptide inhibited inflammatory pain by blocking NMDA receptor-mediated nociceptive transmission in spinal dorsal horn of mice

2015 ◽  
Vol 89 ◽  
pp. 290-297 ◽  
Author(s):  
Wen-Tao Wang ◽  
Guo-Qiang Pan ◽  
Zi-Yang Zhang ◽  
Zhan-Wei Suo ◽  
Xian Yang ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Dorsal Horn ◽  
Inflammatory Pain ◽  
Spinal Dorsal Horn ◽  
Nociceptive Transmission ◽  
Spinal Dorsal

Structural and Molecular Alterations of Primary Afferent Fibres in the Spinal Dorsal Horn in Vincristine-Induced Neuropathy in Rat

2013 ◽  
Vol 51 (3) ◽  
pp. 880-892 ◽  
Author(s):  
Karine Thibault ◽  
Isabelle Rivals ◽  
Saïd M’Dahoma ◽  
Sophie Dubacq ◽  
Sophie Pezet ◽  
...  
Keyword(s):  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Primary Afferent ◽  
Molecular Alterations ◽  
Spinal Dorsal
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