The objective: to investigate the relationship between clinical manifestations of neuropsychological disorders and neuroimaging data (MRI) and electrophysiological (EEG mapping, somatosensory evoked potentials) methods of diagnosis in patients with multiple sclerosis (MS) in the aspect of comorbidity.
Patients and methods. Achieved the clinical, neuropsychological, instrumental study 216 MS patients with the presence of (107) or absence (109) comorbid pathology. Spend a numerical score of neurological deficit symptoms (the FS scale) with the total score counting, defined EDSS level evaluated symptoms of fatigue (the FSS), pain (VAS), depression (BDI-II), the degree of cognitive impairment (MMSE). Implemented neyrovizualizuatsionnoe (MRI) study of the brain and spinal cord and EEG mapping study of electrical activity (EA) of the brain., somatosensory evoked potentials (SSEP).
Results. It is found that the presence of foci of demyelination in the brain stem in both groups correlated with the severity of the manifestations of depression BDI-II data. It also shows that about 65% of both groups of MS patients had signs of decrease ascending activating effects on the cortex from the reticular formation of the brainstem. It was found that 70% of MS patients in both groups there are irritative and hypersynchronous types EA brain, reducing the symptoms of seizure threshold, with the presence of a strong direct correlation between them and multimodal pain.
Conclusions. In the presence of comorbid disease in MS patients observed clinically deeper and more frequent manifestations of NPM, which is confirmed by the results of neuropsychological testing conducted. The presence of foci of demyelination in the cervical spinal cord was significantly more frequent in the MS group with comorbidity (p<0.05), and both groups of patients clinically directly correlates with the severity of pain according to VAS.
Whole-scalp EEG mapping of somatosensory evoked potentials in macaque monkeys
