Phase I/II study of the tumour-targeting human monoclonal antibody–cytokine fusion protein L19-TNF in patients with advanced solid tumours

G. Spitaleri; R. Berardi; C. Pierantoni; T. De Pas; C. Noberasco; C. Libbra; R. González-Iglesias; L. Giovannoni; A. Tasciotti; D. Neri; H. D. Menssen; F. de Braud

doi:10.1007/s00432-012-1327-7

Phase I/II study of the tumour-targeting human monoclonal antibody–cytokine fusion protein L19-TNF in patients with advanced solid tumours

Journal of Cancer Research and Clinical Oncology ◽

10.1007/s00432-012-1327-7 ◽

2012 ◽

Vol 139 (3) ◽

pp. 447-455 ◽

Cited By ~ 68

Author(s):

G. Spitaleri ◽

R. Berardi ◽

C. Pierantoni ◽

T. De Pas ◽

C. Noberasco ◽

...

Keyword(s):

Monoclonal Antibody ◽

Fusion Protein ◽

Phase I ◽

Human Monoclonal Antibody ◽

Solid Tumours ◽

Tumour Targeting

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PHASE I/II STUDY OF THE TUMOUR-TARGETING HUMAN L19- IL2 MONOCLONAL ANTIBODY-CYTOKINE FUSION PROTEIN IN PATIENTS WITH ADVANCED RENAL CELL CARCINOMA

European Urology Supplements ◽

10.1016/s1569-9056(08)60941-0 ◽

2008 ◽

Vol 7 (3) ◽

pp. 307

Author(s):

M. Johannsen ◽

A. Roemer ◽

J. Roigas ◽

G. Curigliano ◽

G. Spitaleri ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Monoclonal Antibody ◽

Fusion Protein ◽

Phase I ◽

Cell Carcinoma ◽

Renal Cell ◽

Advanced Renal Cell Carcinoma ◽

Tumour Targeting

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A universal surrogate peptide to enable LC-MS/MS bioanalysis of a diversity of human monoclonal antibody and human Fc-fusion protein drug candidates in pre-clinical animal studies

Biomedical Chromatography ◽

10.1002/bmc.2759 ◽

2012 ◽

pp. n/a-n/a ◽

Cited By ~ 8

Author(s):

Michael T. Furlong ◽

Zheng Ouyang ◽

Steven Wu ◽

James Tamura ◽

Timothy Olah ◽

...

Keyword(s):

Monoclonal Antibody ◽

Fusion Protein ◽

Animal Studies ◽

Human Monoclonal Antibody ◽

Protein Drug ◽

Drug Candidates ◽

Fc Fusion Protein ◽

Surrogate Peptide

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First in human, a phase I study of ISU104, a novel ErbB3 monoclonal antibody, in patients with advanced solid tumours

Annals of Oncology ◽

10.1093/annonc/mdz244.016 ◽

2019 ◽

Vol 30 ◽

pp. v168

Author(s):

S.-B. Kim ◽

B. Keam ◽

S. Shin ◽

Y.S. Chae ◽

T.M. Kim ◽

...

Keyword(s):

Monoclonal Antibody ◽

Phase I ◽

Phase I Study ◽

Solid Tumours

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CNTO 95, a fully human monoclonal antibody to alpha-v integrins: results of a phase I/II study in patients with metastatic melanoma

Melanoma Research ◽

10.1097/00008390-200609001-00069 ◽

2006 ◽

Vol 16 (Supplement 1) ◽

pp. S39-S40 ◽

Cited By ~ 1

Author(s):

S. O??Day ◽

J. Richards ◽

R. Corringham ◽

R. Beckman ◽

Z. Lang ◽

...

Keyword(s):

Monoclonal Antibody ◽

Phase I ◽

Metastatic Melanoma ◽

Human Monoclonal Antibody

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Abstract B55: Phase I/II study of the tumor‐targeting human L19TNF‐monoclonal antibody‐cytokine fusion protein in patients with advanced solid tumors

10.1158/1535-7163.targ-09-b55 ◽

2009 ◽

Author(s):

Gianluca Spitaleri ◽

Tommaso M. De Pas ◽

Cristina Noberasco ◽

Leonardo Giovannoni ◽

Hans D. Menseen ◽

...

Keyword(s):

Monoclonal Antibody ◽

Fusion Protein ◽

Phase I ◽

Solid Tumors ◽

Tumor Targeting ◽

Advanced Solid Tumors

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Abstract LB-410: Phase I dose escalation study of MM-121, a fully human monoclonal antibody to ErbB3, in patients with advanced solid tumors

10.1158/1538-7445.am2011-lb-410 ◽

2011 ◽

Cited By ~ 3

Author(s):

Crystal S. Denlinger ◽

Vicki L. Keedy ◽

James M. Cleary ◽

William Kubasek ◽

Matthew Onsum ◽

...

Keyword(s):

Monoclonal Antibody ◽

Phase I ◽

Solid Tumors ◽

Dose Escalation ◽

Human Monoclonal Antibody ◽

Advanced Solid Tumors ◽

Dose Escalation Study

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A phase Ia/Ib trial of the anti-programmed death-ligand 1 (PD-L1) human monoclonal antibody (mAb), CS1001, in patients (pts) with advanced solid tumours or lymphomas

Annals of Oncology ◽

10.1093/annonc/mdz253.093 ◽

2019 ◽

Vol 30 ◽

pp. v516

Author(s):

L. Shen ◽

J. Li ◽

N. Xu ◽

B. Xing ◽

Q. Zhang ◽

...

Keyword(s):

Monoclonal Antibody ◽

Human Monoclonal Antibody ◽

Solid Tumours ◽

Programmed Death Ligand 1 ◽

Programmed Death

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Phase I study of CNTO 95, a fully human monoclonal antibody (mAb) to αv integrins, in patients with solid tumors

Journal of Clinical Oncology ◽

10.1200/jco.2004.22.14_suppl.3119 ◽

2004 ◽

Vol 22 (14_suppl) ◽

pp. 3119-3119 ◽

Cited By ~ 2

Author(s):

G. C. Jayson ◽

S. Mullamitha ◽

C. Ton ◽

J. Valle ◽

M. Saunders ◽

...

Keyword(s):

Monoclonal Antibody ◽

Phase I ◽

Solid Tumors ◽

Phase I Study ◽

Human Monoclonal Antibody

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Phase I study of a fully human monoclonal antibody to the tumor necrosis factor-related apoptosis-inducing ligand death receptor 4 (TRAIL-R1) in subjects with advanced solid malignancies or non-Hodgkin's lymphoma (NHL)

Journal of Clinical Oncology ◽

10.1200/jco.2004.22.90140.2533 ◽

2004 ◽

Vol 22 (14_suppl) ◽

pp. 2533-2533 ◽

Cited By ~ 5

Author(s):

L. H. Le ◽

H. W. Hirte ◽

S. J. Hotte ◽

M. Maclean ◽

A. Iacobucci ◽

...

Keyword(s):

Monoclonal Antibody ◽

Tumor Necrosis Factor ◽

Phase I ◽

Phase I Study ◽

Tumor Necrosis ◽

Human Monoclonal Antibody ◽

Death Receptor ◽

Solid Malignancies ◽

Death Receptor 4 ◽

Necrosis Factor

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Phase I and pharmacokinetic study of HGS-ETR2, a human monoclonal antibody to TRAIL R2, in patients with advanced solid malignancies

Journal of Clinical Oncology ◽

10.1200/jco.2005.23.16_suppl.3055 ◽

2005 ◽

Vol 23 (16_suppl) ◽

pp. 3055-3055 ◽

Cited By ~ 10

Author(s):

S. Pacey ◽

R. E. Plummer ◽

G. Attard ◽

C. Bale ◽

A. H. Calvert ◽

...

Keyword(s):

Monoclonal Antibody ◽

Phase I ◽

Pharmacokinetic Study ◽

Human Monoclonal Antibody ◽

Solid Malignancies

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