Common genetic variants on 3q28 contribute to non-small cell lung cancer susceptibility: evidence from 10 case-control studies

2014 ◽  
Vol 290 (2) ◽  
pp. 573-584 ◽  
Author(s):  
Yu-xing Jin ◽  
Ge-ning Jiang ◽  
Hui Zheng ◽  
Liang Duan ◽  
Jia-an Ding
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Genetic Variants ◽  
Cancer Susceptibility ◽  
Case Control ◽  
Small Cell ◽  
Small Cell Lung ◽  
Case Control Studies ◽  
Common Genetic Variants ◽  
Lung Cancer Susceptibility

scholarly journals Genetic evaluation of the variants using MassARRAY in non-small cell lung cancer among North Indians

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Gh. Rasool Bhat ◽  
Itty Sethi ◽  
Amrita Bhat ◽  
Sonali Verma ◽  
Divya Bakshi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Association Study ◽  
Cell Lung Cancer ◽  
Genetic Variants ◽  
Case Control ◽  
Small Cell ◽  
Small Cell Lung ◽  
Case Control Studies ◽  
Control Association

AbstractLung cancer is genetically diverse and a major health burden. Non-small cell lung cancer (NSCLC) accounts for 80% of total lung cancer cases and 20% cases are Small cell lung cancer (SCLC). The present case–control association study focused on the cost effective high throughput genotyping using Agena MassARRAY matrix-assisted laser desorption/ionization-time of flight, mass spectrometry (MALDI-TOF) platform to analyze the genetic association of candidate genetic variants. We performed multiplex PCR and genotyped twelve single nucleotide polymorphisms (SNPs) in 723 samples (162 NSCLC cases and 592 healthy controls). These genetic variants were selected from literature for their association with various cancers worldwide and this is the first study from the region to examine these critically important genetic variants. With prospective case–control association study design, twelve variants from ten genes were evaluated. Amongst these six variants, TCF21 (rs12190287), ERCC1 (rs2298881, 11615), ERCC5 (rs751402), ARNTL (rs4757151), BRIP1 (rs4986764) showed significant association with NSCLC risk (p ≤ 0.003) in Jammu and Kashmir population. In-silico findings of these genetic variants showed remarkable functional roles that needs in-vitro validations. It is further anticipated that such case control studies will help us in understanding the missing heritability of non-small cell lung cancer.

scholarly journals XAB2 tagSNPs contribute to non-small cell lung cancer susceptibility in Chinese population

BMC Cancer ◽  
2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Na Pei ◽  
Lei Cao ◽  
Yingwen Liu ◽  
Jing Wu ◽  
Qinqin Song ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Chinese Population ◽  
Cancer Susceptibility ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer Susceptibility

The 18p11.22 locus is associated with never smoker non-small cell lung cancer susceptibility in Korean populations

2011 ◽  
Vol 131 (3) ◽  
pp. 365-372 ◽  
Author(s):  
Myung-Ju Ahn ◽  
Hong-Hee Won ◽  
Jeeyun Lee ◽  
Seung-Tae Lee ◽  
Jong-Mu Sun ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Cancer Susceptibility ◽  
Small Cell ◽  
Small Cell Lung ◽  
Never Smoker ◽  
Lung Cancer Susceptibility

Relevance of N-acetyltransferase 1 and 2 (NAT1, NAT2) genetic polymorphisms in non-small cell lung cancer susceptibility

2001 ◽  
Vol 11 (2) ◽  
pp. 157-168 ◽  
Author(s):  
H. Wikman ◽  
S. Thiel ◽  
B. J??ger ◽  
P. Schmezer ◽  
B. Spiegelhalder ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Genetic Polymorphisms ◽  
Cell Lung Cancer ◽  
Cancer Susceptibility ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer Susceptibility
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