Expression of nitric oxide synthase isoforms (NOS II and NOS III) in adult rat lung in hyperoxic pulmonary hypertension

1999 ◽  
Vol 295 (2) ◽  
pp. 317-329 ◽  
Author(s):  
Wolfgang Steudel ◽  
Masazumi Watanabe ◽  
Krikor Dikranian ◽  
Margaretha Jacobson ◽  
R. C. Jones
Keyword(s):  
Nitric Oxide ◽  
Pulmonary Hypertension ◽  
Nitric Oxide Synthase ◽  
Rat Lung ◽  
Adult Rat ◽  
Oxide Synthase

Prolonged in vivo hypoxia enhances nitric oxide synthase type I and type III gene expression in adult rat lung.

1995 ◽  
Vol 13 (2) ◽  
pp. 167-174 ◽  
Author(s):  
P W Shaul ◽  
A J North ◽  
T S Brannon ◽  
K Ujiie ◽  
L B Wells ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Type I ◽  
Rat Lung ◽  
Type Iii ◽  
Adult Rat ◽  
Oxide Synthase

scholarly journals Effects of chronic hypoxia and altered hemodynamics on endothelial nitric oxide synthase expression in the adult rat lung.

1998 ◽  
Vol 101 (4) ◽  
pp. 795-801 ◽  
Author(s):  
T D Le Cras ◽  
R C Tyler ◽  
M P Horan ◽  
K G Morris ◽  
R M Tuder ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Chronic Hypoxia ◽  
Rat Lung ◽  
Adult Rat ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Effects of Chronic Hypoxia and Altered Hemodynamics on Endothelial Nitric Oxide Synthase and Preproendothelin-1 Expression in the Adult Rat Lung

CHEST Journal ◽  
1998 ◽  
Vol 114 (1) ◽  
pp. 35S-36S ◽  
Author(s):  
Timothy D. Le Cras ◽  
Robert C. Tyler ◽  
Marilee P. Horan ◽  
Ken G. Morris ◽  
Ivan F. McMurty ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Chronic Hypoxia ◽  
Rat Lung ◽  
Adult Rat ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Nitric oxide synthase inhibitors protect cerebellar Purkinje cells from zinc-induced cell loss in adult rat

2011 ◽  
Vol 41 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Mehmet Fatih Gökçe ◽  
Süleyman Kaplan ◽  
Ayten Türkkani ◽  
Ramazan Kozan ◽  
Mustafa Ayyildiz ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Purkinje Cells ◽  
Cell Loss ◽  
Nitric Oxide Synthase Inhibitors ◽  
Adult Rat ◽  
Cerebellar Purkinje Cells ◽  
Oxide Synthase

Nitric oxide synthase type I and type III gene expression are developmentally regulated in rat lung

1994 ◽  
Vol 266 (6) ◽  
pp. L635-L641 ◽  
Author(s):  
A. J. North ◽  
R. A. Star ◽  
T. S. Brannon ◽  
K. Ujiie ◽  
L. B. Wells ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Fetal Lung ◽  
Mrna Abundance ◽  
Type I ◽  
Fetal Life ◽  
Rat Lung ◽  
Developmentally Regulated ◽  
Oxide Synthase

The successful transition from fetal to neonatal life involves a marked decline in pulmonary vascular resistance which is modulated in part by endothelium-derived nitric oxide. To define the molecular processes which prepare the pulmonary circulation for nitric oxide mediation of vasodilatation at the time of birth, we determined the ontogeny of endothelial nitric oxide synthase (NOS-III) gene expression in lungs from fetal and newborn rats. Maturational changes in lung neuronal NOS (NOS-I) expression were also investigated; the latter isoform has been localized to rat bronchiolar epithelium. NOS proteins were examined by immunoblot analysis, and mRNA abundance was assessed in reverse transcription-polymerase chain reaction assays. Both NOS-III and NOS-I protein were detectable in 16-day fetal lung, they increased 3.8- and 3.1-fold, respectively, to maximal levels at 20 days of gestation (term = 22 day), and they fell postnatally (1-5 days). In parallel with the findings for NOS-III protein, NOS-III mRNA increased from 16 to 20 days gestation and fell after birth. In contrast, NOS-I mRNA abundance declined during late fetal life and rose postnatally. These findings were confirmed by Northern analyses. Thus NOS-III and NOS-I gene expression are developmentally regulated in rat lung, with maximal NOS-III and NOS-I protein present near term. The regulation of pulmonary NOS-III may primarily involve alterations in transcription or mRNA stability, whereas NOS-I expression in the maturing lung may also be mediated by additional posttranscriptional processes.

scholarly journals Inducible nitric oxide synthase after sensitization and allergen challenge of Brown Norway rat lung

1997 ◽  
Vol 121 (7) ◽  
pp. 1241-1246 ◽  
Author(s):  
Shu Fang Liu ◽  
El-Bdaoui Haddad ◽  
Ian Adcock ◽  
Michael Salmon ◽  
Hiro Koto ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Allergen Challenge ◽  
Brown Norway ◽  
Rat Lung ◽  
Norway Rat ◽  
Brown Norway Rat ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

IMMUNOHISTOCHEMICAL DISTRIBUTION OF NITRIC OXIDE SYNTHASE IN NORMOXIC VERSUS HYPOXIC RAT LUNG

1994 ◽  
Vol 81 (SUPPLEMENT) ◽  
pp. A649
Author(s):  
R. A. Johns ◽  
C. Xue ◽  
A. Rengasmy ◽  
T. D. Le Cras ◽  
P. Koberna ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Rat Lung ◽  
Oxide Synthase
Sign in / Sign up

Export Citation Format

Share Document