In situ surgical procedures for locally advanced pancreatic cancer: partial abdominal evisceration and intestinal autotransplantation

2009 ◽  
Vol 16 (6) ◽  
pp. 771-776 ◽  
Author(s):  
Hodaka Amano ◽  
Fumihiko Miura ◽  
Naoyuki Toyota ◽  
Keita Wada ◽  
Ken-ichirou Katoh ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Surgical Procedures ◽  
Locally Advanced ◽  
Advanced Pancreatic Cancer ◽  
Locally Advanced Pancreatic Cancer ◽  
Intestinal Autotransplantation

A Critical Overview of Systematic Reviews of Chemotherapy for Advanced and Locally Advanced Pancreatic Cancer using both AMSTAR2 and ROBIS as Quality Assessment Tools

2020 ◽  
Vol 15 ◽  
Author(s):  
Amit Dang ◽  
Surendar Chidirala ◽  
Prashanth Veeranki ◽  
BN Vallish
Keyword(s):  
Pancreatic Cancer ◽  
High Risk ◽  
Systematic Reviews ◽  
Locally Advanced ◽  
Advanced Pancreatic Cancer ◽  
Risk Of Bias ◽  
Low Risk ◽  
Locally Advanced Pancreatic Cancer ◽  
Grade 3 ◽  
Critical Overview

Background: We performed a critical overview of published systematic reviews (SRs) of chemotherapy for advanced and locally advanced pancreatic cancer, and evaluated their quality using AMSTAR2 and ROBIS tools. Materials and Methods: PubMed and Cochrane Central Library were searched for SRs on 13th June 2020. SRs with metaanalysis which included only randomized controlled trials and that had assessed chemotherapy as one of the treatment arms were included. The outcome measures, which were looked into, were progression-free survival (PFS), overall survival (OS), and adverse events (AEs) of grade 3 or above. Two reviewers independently assessed all the SRs with both ROBIS and AMSTAR2. Results: Out of the 1,879 identified records, 26 SRs were included for the overview. Most SRs had concluded that gemcitabine-based combination regimes, prolonged OS and PFS, but increased the incidence of grade 3-4 toxicities, when compared to gemcitabine monotherapy, but survival benefits were not consistent when gemcitabine was combined with molecular targeted agents. As per ROBIS, 24/26 SRs had high risk of bias, with only 1/26 SR having low risk of bias. As per AMSTAR2, 25/26 SRs had critically low, and 1/26 SR had low, confidence in the results. The study which scored ‘low’ risk of bias in ROBIS scored ‘low confidence in results’ in AMSTAR2. The inter-rater reliability for scoring the overall confidence in the SRs with AMSTAR2 and the overall domain in ROBIS was substantial; ROBIS: kappa=0.785, SEM=0.207, p<0.001; AMSTAR2: kappa=0.649, SEM=0.323, p<0.001. Conclusion: Gemcitabine-based combination regimens can prolong OS and PFS but also worsen AEs when compared to gemcitabine monotherapy. The included SRs have an overall low methodological quality and high risk of bias as per AMSTAR2 and ROBIS respectively.

Maintenance therapy with alpha-interferon (IFN-α) in locally advanced pancreatic cancer (LAPC): A pilot study

Pancreatology ◽  
2012 ◽  
Vol 12 (6) ◽  
pp. 558-559
Author(s):  
S. Cereda ◽  
A. Rognone ◽  
C. Belli ◽  
P. Passoni ◽  
N. Slim ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Pilot Study ◽  
Maintenance Therapy ◽  
Locally Advanced ◽  
Advanced Pancreatic Cancer ◽  
Locally Advanced Pancreatic Cancer ◽  
Alpha Interferon

scholarly journals Conversion pancreaticoduodenectomy with dual arterial reconstructions for locally advanced pancreatic cancer: Case report and literature review

2021 ◽  
Vol 80 ◽  
pp. 105692
Author(s):  
Yasutoshi Kimura ◽  
Masafumi Imamura ◽  
Tatsuya Itoh ◽  
Takatoshi Yotsuyanagi ◽  
Nobuyoshi Kawaharada ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Case Report ◽  
Literature Review ◽  
Locally Advanced ◽  
Advanced Pancreatic Cancer ◽  
Locally Advanced Pancreatic Cancer ◽  
Cancer Case

scholarly journals Geographic Variation in Attitudes Regarding Locally Advanced Pancreatic Cancer Management

HPB ◽  
2021 ◽  
Vol 23 ◽  
pp. S53
Author(s):  
A.B. Blair ◽  
B. Reames ◽  
R. Krell ◽  
A. Ejaz ◽  
M. Falconi ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Geographic Variation ◽  
Locally Advanced ◽  
Advanced Pancreatic Cancer ◽  
Locally Advanced Pancreatic Cancer ◽  
Cancer Management
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