Effect of intravenous dezocine on fentanyl-induced cough during general anesthesia induction: a double-blinded, prospective, randomized, controlled trial

2011 ◽  
Vol 25 (6) ◽  
pp. 860-863 ◽  
Author(s):  
Zhen-Tao Sun ◽  
Chun-Yao Yang ◽  
Zhi Cui ◽  
Jie Zhang ◽  
Xue-Ping Han
Keyword(s):  
Randomized Controlled Trial ◽  
General Anesthesia ◽  
Controlled Trial ◽  
Anesthesia Induction ◽  
Randomized Controlled ◽  
Prospective Randomized Controlled Trial ◽  
Double Blinded

scholarly journals Comparison of a small dose of oxycodone and sufentanil for the prevention of sufentanil-induced cough during general anesthesia induction: a prospective randomized controlled trial

2021 ◽  
Author(s):  
Lingli Shi ◽  
Yong He ◽  
Huanhuan Ni
Keyword(s):  
Randomized Controlled Trial ◽  
General Anesthesia ◽  
Small Dose ◽  
Elective Surgery ◽  
Controlled Trial ◽  
Anesthesia Induction ◽  
Clinical Trial Registry ◽  
Randomized Controlled ◽  
Prospective Randomized Controlled Trial ◽  
Hemodynamic State

Abstract Background: Sufentanil is widely used during anesthesia induction. However, sufentanil injections can cause cough through different mechanisms. This study aimed to evaluate the effectiveness of a small dose of oxycodone and sufentanil in suppressing sufentanil-induced cough (SIC) during general anesthesia induction.Methods: This prospective, randomized, controlled trial was conducted form February 12, 2019 to December 30, 2019. A total of 174 patients were scheduled for elective surgery, and 144 screened patients were randomly divided into 3 groups (n=48). Five minutes before sufentanil bolus (0.4 μg/kg), patients in group O received 0.02 mg/kg oxycodone intravenously within 5 s, those in group S received 0.02 μg/kg sufentanil within 5 s and those in group N received an equal volume of 0.9% normal saline within 5 s. Sufentanil was diluted to 5 μg/ml and administered within 5 s after pretreatment. The incidence and severity of cough in the three groups were evaluated within 1 minute after sufentanil injection during anesthesia induction. Mean arterial pressure (MAP) and heart rate (HR) were recorded at T0 (after entering the operation), T1 (3 minutes after pretreatment), T2 (before intubation), and T3 (1 minute after intubation).Results: The incidences of cough in group N, group O, and group S were 20 (41.6%), 7 (14.5%), and 6 (12.5%), respectively. Compared with group N, group O and group S exhibited significantly reduced incidence and severity of cough, and the severity of cough in group O and group S was dramatically reduced compared with that in group N (P<0.05). No significant differences in the rangeability of MAP and HR were noted at the four time points in the three groups (P> 0.05).Conclusion: Intravenous oxycodone (0.02 mg/kg) and sufentanil (0.02 μg/kg) represent effective approaches to reducing SIC in anesthesia induction and ensuring a relatively stable hemodynamic state during general anesthesia induction.Trial registration: Chinese Clinical Trial Registry (ChiCTR1900021087, registered date: January 28, 2019), http://www.chictr.org.cn

Acupuncture accelerates recovery after general anesthesia: a prospective randomized controlled trial

2015 ◽  
Vol 13 (2) ◽  
pp. 99-104 ◽  
Author(s):  
Marco Gemma ◽  
Elisa Nicelli ◽  
Luigi Gioia ◽  
Elena Moizo ◽  
Luigi Beretta ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
General Anesthesia ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Prospective Randomized Controlled Trial

scholarly journals Comparison of the combination of propofol and etomidate versus propofol or etomidate alone for induction of general anesthesia: a double-blind, randomized controlled trial

2021 ◽  
Author(s):  
Yun Li ◽  
Wenze Lu ◽  
David Li ◽  
Jon Zhou ◽  
Richard Applegate ◽  
...  
Keyword(s):  
Heart Rate ◽  
Randomized Controlled Trial ◽  
General Anesthesia ◽  
Controlled Trial ◽  
Anesthesia Induction ◽  
Double Blind ◽  
Randomized Controlled ◽  
Hemodynamic Variables ◽  
Processed Eeg ◽  
Induction Agents

IntroductionHemodynamic fluctuation during the induction of general anesthesia is a common event and adversely affect patients’ outcomes. The aim of this study is to investigate the impacts of different anesthesia induction agents: propofol, etomidate, and propofol-etomidate combination on patient hemodynamics and processed electroencephalography (EEG).Material and methodsSeventy-five patients undergoing elective non-cardiac surgery were randomly assigned to three groups of anesthesia induction agents: the group P received 2 mg/kg propofol, the group E received 0.3 mg/kg etomidate, and the group PE received the combination of 1mg/kg propofol plus 0.15mg/kg etomidate. Hemodynamic variables and processed EEG were measured during induction.ResultsHeart rate (HR) was significantly increased at intubation and 1 min after intubation compared with baseline in all three groups. Mean arterial pressure (MAP) decreased significantly after induction, at 5, and 10 min after intubation in group P (79.1±12.6, 77.0±14.2, 76.6±11.4 versus 93.2±9.9 mmHg; all P＜0.001). MAP increased significantly at intubation and 1 min after intubation in group E (104.7±13.0, 103.8±12.8 versus 92.9±10.2; P＜0.001, P=0.001 respectively). The incidence of myoclonus was lower in groups PE (4.0%) and P (4.0%) compared with that in group E (24.0%) (P=0.033). The incidence of pain at injection was higher in group P (28.0%) than that in groups PE and E (4.0% and 0.0%) (P=0.025).ConclusionsThe combination of propofol and etomidate used during induction of anesthesia provided a more stable BP profile, less pain at site of injection, and decreased myoclonic movements compared with propofol or etomidate alone.

Sign in / Sign up

Export Citation Format

Share Document