PROPHYLACTIC BILATERAL INTERNAL ILIAC ARTERY LIGATION, IN PREVENTION OF PPH, IN A CASE OF MULTIPLE LARGE INTRA MURAL FIBROIDS

Postpartum haemorrhage is dened as a blood loss of more than 500ml after delivery of the placenta. It is a clinical diagnosis that encompasses excessive blood loss after delivery of the baby from a variety of sites: uterus, cervix, 1 vagina and perineum

Blood coagulation components in GtoPdb v.2021.2

Coagulation as a process is interpreted as a mechanism for reducing excessive blood loss through the generation of a gel-like clot local to the site of injury. The process involves the activation, adhesion (see Integrins), degranulation and aggregation of platelets, as well as proteins circulating in the plasma. The coagulation cascade involves multiple proteins being converted to more active forms from less active precursors (for example, prothrombin [Factor II] is converted to thrombin [Factor IIa]), typically through proteolysis (see Proteases). Listed here are the components of the coagulation cascade targeted by agents in current clinical usage or at an advanced level of development.

Bloodless surgery and gynecological patients among Jehovah’s Witnesses

Overview Objective: The aim of this research is to present our experiences with the surgical treatment of gynecological patients among Jehovah’s Witnesses. Moreover, the medical, moral, and ethical problems in this regard have been highlighted. Methods: 75 Jehovah’s Witnesses patients were operated on for various benign and malignant gynecological diseases between 2007 and 2018. All of these patients were operated on according to the rules of blood-sparing surgery. Results: The operations were assessed according to the dia­gnosis, mode of surgery, estimated blood loss, and disease outcome. Excessive blood loss did not occur during any of these operations, and the estimated blood loss for the same procedure was 10 to 550 mL. Conclusion: Jehovah’s Witnesses gynecological patients is a group of high-risk patients because they refuse to undergo blood transfusion. Nevertheless, the principles of blood-sparing surgery should be applied to not only Jehovah’s Witnesses patients but also to all patients in general. Even if a blood transfusion is the last resort to solve issues pertaining to excessive blood loss during complicated operations, the said procedure always carries certain risks. Therefore, blood transfusion should be performed only on rare occasions. Jehovah’s Witnesses patients categorically refuse blood transfusion even if it is the only way to save one’s life. Even though the legislation of the Czech Republic deals with this problem, there are other moral and ethical aspects that need to be addressed in this regard. Keywords: bloodless surgery – Gynecologic surgery – Jehovah’s Witnesses – legislation – moral and ethical problems

Upaya Cara Mengatasi Disminore pada Remaja Putri

Dismenore muncul dengan berbagai jenis rasa nyeri,sepeti sakit yang teramat sangat, berdenyut, mual, nyeri seperti terbakar, atau sakit yang sangat menusuk.Dismenore bisa mendahului menstruasi dengan beberapa hari atau mungkin menyertainya, dan biasanya berkurang hingga akhir menstruasi. Dismenore bisa hidup berdampingan dengan kehilangan darah berlebihan berat, yang dikenal sebagai menorrhagia. Dalam keadaan yang normal, nyeri haid hanya membuat wanita merasa sakit dan tidak nyaman. Tetapi dalam keadaan yang parah, nyeri haid ini bisa membuat wanita tidak dapat bekerja dan harus beristirahat, nyeri sering bersamaan dengan rasa mual, sakit kepala, perasaan mau pingsan dan lekas marah..Tujuan kegiatan pengabdian masyarakat adalah mengetahui dan memahami tentang nyeri haid/disminore serta mengetahui dan memahami cara penanganan nyeri haid/disminore sehingga tidak mengganggu aktivitas selama pembelajaran di sekolah. Kegiatan dilaksanakan dua kali yaitu pertemuan pertama dengan memberikan penyuluhan tentang upaya cara mengatasi nyeri haid/disminore pada remaja putri. pertemuan kedua dengan demonstrasi cara mengatasi nyeri haid/disminore pada remaja putri. Hasil dari pengabdian menunjukkan bahwa ada peningkatan pengetahuan tentang nyeri haid/disminore serta mengetahui dan memahami cara penanganan nyeri haid/disminore. Kata kunci: disminore; menstruasi; remaja putri EFFORTS HOW TO OVERCOME DISMINORE IN PRINCESS ADOLESCENTS ABSTRACT Dysmenorrhea presents with various types of pain, such as extreme pain, throbbing, nausea, burning pain, or very sharp pain. Dysmenorrhea can precede menstruation by several days or may accompany it, and usually decreases until the end of menstruation. Dysmenorrhea can coexist with heavy excessive blood loss, known as menorrhagia. Under normal circumstances, menstrual pain only makes women feel sick and uncomfortable. But in severe conditions, menstrual pain can make a woman unable to work and must rest, pain often coincides with nausea, headaches, feelings of fainting and irritability. The purpose of community service activities is to know and understand menstrual pain/ disminore as well as knowing and understanding how to manage menstrual pain / disminore so that it does not interfere with activities during learning at school. Activities carried out twice, namely the first meeting by providing counseling about efforts to overcome menstrual pain/ disminore in princess adolescents. The second meeting with a demonstration of how to overcome menstrual pain/ disminore in princess adolescents. The results of devotion show that there is an increase in knowledge about menstrual pain/ disminore and knowing and understanding how to manage menstrual pain / disminore. Keywords: disminore, menstruation, princess adolescents

PENGUKURAN DAN APLIKASI KLINIK THROMBIN ACTIVATABLE FIBRINOLYSIS INHIBITOR

Cross regulation of coagulation and fibrinolysis plays an important role in preserving a balanced hemostatic process. These process are exquisitely regulated and protect the organism from excessive blood loss or excessive fibrin deposition. Identification of ThrombinActivatable Fibrinolysis Inhibitor (TAFI) as an inhibitor of fibrinolysis and one of the main intermediates between coagulation andfibrinolysis, greatly improved our understanding of cross regulation of coagulation and fibrinolysis. As TAFI is an enzyme that is activatedby thrombin generated by the coagulation system, its activation is sensitive to the dynamics of the coagulation system. This review willdiscuss the role of TAFI and characterize it with respect to its activation, regulation, and clinical application.