scholarly journals Serum TRAIL levels increase shortly after insulin therapy and metabolic stabilization in children with type 1 diabetes mellitus

2015 ◽  
Vol 52 (5) ◽  
pp. 1003-1006 ◽  
Author(s):  
Gianluca Tornese ◽  
Veronica Tisato ◽  
Lorenzo Monasta ◽  
Liza Vecchi Brumatti ◽  
Giorgio Zauli ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Insulin Therapy ◽  
Type 1 Diabetes Mellitus

scholarly journals General Principles for Rehabilitation of Patients With Type 1 Diabetes and Diabetic Nephropathy

2021 ◽  
Vol 7 (12) ◽  
pp. 97-103
Author(s):  
O. Terekhova ◽  
Furtikova
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Diabetic Nephropathy ◽  
Insulin Therapy ◽  
Type 1 Diabetes Mellitus ◽  
Diabetic Complications ◽  
Late Complications ◽  
Genetically Engineered ◽  
Self Control

All over the world, an increase in type 1 diabetes mellitus is noted annually, along with its late complications. In recent years, more and more information has appeared aimed at the prevention and rehabilitation of children with diabetes. Type 1 diabetes mellitus is a genetically determined disease, in the development of which the main component is an autoimmune process that triggers the destruction of β-cells, which leads to a decrease in insulin production, and subsequently to its absolute insufficiency, the main method of treatment is insulin replacement therapy. To select an adequate dose of insulin, it is necessary to take into account HbA1c, glycemic and glucosuric profiles. Children are advised to use semi-synthetic or genetically engineered insulins. In children, intensified insulin therapy is more often used in the form of a combination of short and medium-acting insulins or ultra-short with prolonged ones. This article presents an analysis of insulin therapy and self-control in children and adolescents with type 1 diabetes mellitus and diabetic nephropathy. It was found that children with diabetic nephropathy approached their illness less responsibly, did not always count bread units and kept records in self-control diaries. Also, this group of children were more likely to receive human insulin with the use of syringe pens. The nutrition of children with diabetes should not be inferior in calories to that of healthy adolescents, while the energy value of the daily diet should be calculated taking into account age, gender, body weight, and energy expenditures. Taking into account the possibility of regression of the initial diabetic complications when the compensation of carbohydrate metabolism is achieved, therapy for type 1 diabetes is a means of preventing the development of severe diabetic complications.

771-P: The Effect of Adding Acarbose to Insulin Therapy in Type 1 Diabetes Mellitus: A Systematic Review and Meta-analysis

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 771-P
Author(s):  
ZHIGU LIU ◽  
DAIZHI YANG ◽  
WEN XU ◽  
JING LV ◽  
HUIMIN LIN ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type 1 Diabetes ◽  
Insulin Therapy ◽  
Type 1 Diabetes Mellitus ◽  
Meta Analysis

scholarly journals Professional Continuous Glucose Monitoring for the Identification of Type 1 Diabetes Mellitus Among Subjects With Insulin Therapy

Medicine ◽  
2015 ◽  
Vol 94 (3) ◽  
pp. e421 ◽  
Author(s):  
Yin-Chun Chen ◽  
Yu-Yao Huang ◽  
Hung-Yuan Li ◽  
Shih-Wei Liu ◽  
Sheng-Hwu Hsieh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Insulin Therapy ◽  
Type 1 Diabetes Mellitus ◽  
Continuous Glucose Monitoring ◽  
Glucose Monitoring

scholarly journals Insulin Therapy in Adults with Type 1 Diabetes Mellitus: a Narrative Review

2020 ◽  
Vol 11 (2) ◽  
pp. 387-409 ◽  
Author(s):  
Andrej Janež ◽  
Cristian Guja ◽  
Asimina Mitrakou ◽  
Nebojsa Lalic ◽  
Tsvetalina Tankova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Insulin Therapy ◽  
Type 1 Diabetes Mellitus ◽  
Narrative Review

Initial insulin therapy in children and adolescents with type 1 diabetes mellitus

2009 ◽  
Vol 11 (3) ◽  
pp. 159-165 ◽  
Author(s):  
Dieter Weitzela ◽  
Ulla Pfeffera ◽  
Axel Dost ◽  
Antje Herbstc ◽  
Ina Knerr ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Insulin Therapy ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents

scholarly journals Pathogenesis of Type 1 Diabetes Mellitus: A Brief Overview

2012 ◽  
Vol 19 (1) ◽  
pp. 67-72 ◽  
Author(s):  
Adrian Vlad ◽  
Romulus Timar
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Insulin Therapy ◽  
Type 1 Diabetes Mellitus ◽  
Chronic Complications ◽  
Type 1 Dm ◽  
Preventive Methods

Pathogenesis of Type 1 Diabetes Mellitus: A Brief OverviewBefore the discovery of insulin, type 1 diabetes mellitus (DM) was a disease with acute evolution, leading to death shortly after diagnosis. During the first years of insulin therapy, the medical world was optimistic, even enthusiastic, considering that the therapeutic solution for the malady was found. Unfortunately this was only an illusion, because the patients started to develop chronic complications that shortened their lifespan and impaired their quality of life. In other words, insulin therapy transformed type 1 DM into a chronic disease. The prevention or the delay of the onset of hyperglycemia emerged as a new solution for the patients and, consequently, the understanding of the pathogenesis of the disease (a prerequisite for developing efficient preventive methods) became a priority for all the diabetologists involved in research. Almost 40 years have passed since the autoimmune theory regarding the pathogenesis of type 1 DM was imagined but, despite the tremendous research performed in this field since then, the prevention could not be obtained. The aim of this paper is to present the most important theoretic notions regarding the mechanisms that underlie the development of type 1 DM, in the way they are understood today.

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