Circulating miRNA-375 levels are increased in autoantibodies-positive first-degree relatives of type 1 diabetes patients

2019 ◽  
Vol 56 (6) ◽  
pp. 707-710 ◽  
Author(s):  
L. Bertoccini ◽  
F. Sentinelli ◽  
M. Incani ◽  
D. Bailetti ◽  
F. A. Cimini ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Circulating Mirna ◽  
First Degree Relatives ◽  
Diabetes Patients

scholarly journals Extrapancreatic Autoimmune Manifestations in Type 1 Diabetes Patients and Their First-Degree Relatives: A multicenter study

Diabetes Care ◽  
2003 ◽  
Vol 26 (4) ◽  
pp. 1235-1240 ◽  
Author(s):  
A. Hanukoglu ◽  
A. Mizrachi ◽  
I. Dalal ◽  
O. Admoni ◽  
Y. Rakover ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Multicenter Study ◽  
First Degree Relatives ◽  
Diabetes Patients

scholarly journals Ten years follow up of first degree relatives of type 1 diabetes patients: presence of autoimmune biomarkers and the progression to diabetes in a retrospective cohort

2021 ◽  
Author(s):  
Isabella Sued Leão ◽  
Débora Batista Araujo ◽  
Bianca Barone ◽  
Joana Rodrigues Dantas ◽  
Matheus Victor de Souza Nolasco da Silva ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Retrospective Cohort ◽  
First Degree Relatives ◽  
Diabetes Patients

scholarly journals Reduced iNKT cells numbers in type 1 diabetes patients and their first‐degree relatives

2015 ◽  
Vol 3 (4) ◽  
pp. 411-419 ◽  
Author(s):  
Nonantzin Beristain‐Covarrubias ◽  
Elsy Canche‐Pool ◽  
Rita Gomez‐Diaz ◽  
Luvia E. Sanchez‐Torres ◽  
Vianney Ortiz‐Navarrete
Keyword(s):  
Type 1 Diabetes ◽  
Inkt Cells ◽  
First Degree Relatives ◽  
Diabetes Patients

Decreased dendritic cell numbers but increased TLR9-mediated interferon-alpha production in first degree relatives of type 1 diabetes patients

2014 ◽  
Vol 153 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Jana Kayserova ◽  
Jana Vcelakova ◽  
Katerina Stechova ◽  
Eva Dudkova ◽  
Hana Hromadkova ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Dendritic Cell ◽  
Interferon Alpha ◽  
Cell Numbers ◽  
First Degree Relatives ◽  
Alpha Production ◽  
Diabetes Patients

High prevalence of humoral autoimmunity in first-degree relatives of Mexican type 1 diabetes patients

2018 ◽  
Vol 55 (12) ◽  
pp. 1275-1282 ◽  
Author(s):  
Norma C. Segovia-Gamboa ◽  
Martha E. Rodríguez-Arellano ◽  
Andrés Muñoz-Solís ◽  
Jorge E. Retana-Jiménez ◽  
Germán Vargas-Ayala ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
First Degree Relatives ◽  
High Prevalence ◽  
Humoral Autoimmunity ◽  
Diabetes Patients

scholarly journals Genetic variation at ERBB3/IKZF4 and sexual dimorphism in epitope spreading in single autoantibody-positive relatives

Diabetologia ◽  
2021 ◽  
Vol 64 (11) ◽  
pp. 2511-2516
Author(s):  
Julie Vandewalle ◽  
Bart J. Van der Auwera ◽  
Henna Amin ◽  
Erik Quartier ◽  
Aster K. Desouter ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cox Regression ◽  
Epitope Spreading ◽  
Allelic Discrimination ◽  
First Degree Relatives ◽  
Female Sex ◽  
Kaplan Meier ◽  
Antibody Positivity ◽  
Diabetes Patients

Abstract Aims/hypothesis We examined whether the non-HLA susceptibility locus ERBB3/IKZF4 influences progression of type 1 diabetes stage specifically according to sex. Methods SNPs of ERBB3 (rs2292239 T/G) and IKZF4 (rs1701704 G/T) were screened by allelic discrimination quantitative PCR assay in first-degree relatives of type 1 diabetes patients who had developed at least one circulating autoantibody. The effect of ERBB3/IKZF4 genotypes and sex, on the progression of single autoantibody positivity to multiple autoantibody positivity and from multiple autoantibody positivity to diabetes, was studied by Kaplan–Meier analysis and multivariate Cox regression. Results In the cohort of autoantibody-positive first-degree relatives, the risk allele frequencies for ERBB3 rs2292239 (T) and IKZF4 rs1701704 (G) were increased. There was a significant male excess at the stage of multiple autoantibody positivity (p = 0.021). In Kaplan–Meier survival analysis, progression from single to multiple antibody positivity was delayed in female participants with genotype ERBB3 GG (p = 0.018, vs ERBB3 TG+TT) or IKZF4 TT (p = 0.023, vs IKZF4 GT+GG), but not in male participants. In multivariate Cox regression models, the interaction effects between female sex and ERBB3 GG (p = 0.012; HR = 0.305 [95% CI 0.120, 0.773]) or between female sex and IKZF4 TT (p = 0.011; HR = 0.329 [95% CI 0.140, 0.777]) emerged as potential determinants of delayed progression to multiple autoantibodies. The progression from multiple autoantibody positivity to type 1 diabetes appeared not to be influenced by ERBB3/IKZF4. Conclusions/interpretation In siblings and offspring of type 1 diabetes patients, polymorphism in region ERBB3/IKZF4 may affect disease progression at the level of epitope spreading in female individuals. Our findings suggest that interaction between sex and ERBB3/IKZF4 may contribute to the post-pubertal male excess in type 1 diabetes. Graphical abstract

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