Risk of carcinogenesis in the biliary epithelium of children with congenital biliary dilatation through epigenetic and genetic regulation

Surgery Today ◽  
2021 ◽  
Author(s):  
Hiroki Mori ◽  
Kazunori Masahata ◽  
Satoshi Umeda ◽  
Yuji Morine ◽  
Hiroki Ishibashi ◽  
...  
2020 ◽  
Vol 53 ◽  
pp. 101367
Author(s):  
Takeshi Shirai ◽  
Yoshinori Hamada ◽  
Hiroshi Hamada ◽  
Tatsuma Sakaguchi ◽  
Takashi Doi ◽  
...  

2018 ◽  
Vol 34 (10) ◽  
pp. 1079-1086 ◽  
Author(s):  
Hiroaki Fukuzawa ◽  
Naoto Urushihara ◽  
Chisato Miyakoshi ◽  
Keisuke Kajihara ◽  
Insu Kawahara ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Chiyoe Shirota ◽  
Hiroki Kawashima ◽  
Takahisa Tainaka ◽  
Wataru Sumida ◽  
Kazuki Yokota ◽  
...  

AbstractBile duct and anastomotic strictures and intrahepatic stones are common postoperative complications of congenital biliary dilatation (CBD). We performed double-balloon endoscopic retrograde cholangiography (DBERC) for diagnostic and therapeutic purposes after radical surgery. We focused on the effectiveness of DBERC for the treatment of postoperative complications of CBD patients. Bile duct and anastomotic strictures and intrahepatic stones are common postoperative complications of congenital biliary dilatation (CBD). We performed double-balloon endoscopic retrograde cholangiography (DBERC) for diagnostic and therapeutic purposes after radical surgery. We focused on the effectiveness of DBERC for the treatment of postoperative complications of CBD patients. This retrospective study included 28 patients who underwent DBERC (44 procedures) after radical surgery for CBD between January 2011 and December 2019. Strictures were diagnosed as “bile duct strictures” if endoscopy confirmed the presence of bile duct mucosa between the stenotic and anastomotic regions, and as “anastomotic strictures” if the mucosa was absent. The median patient age was 4 (range 0–67) years at the time of primary surgery for CBD and 27.5 (range 8–76) years at the time of DBERC. All anastomotic strictures could be treated with only by 1–2 courses of balloon dilatation of DBERC, while many bile duct strictures (41.2%) needed ≥ 3 treatments, especially those who underwent operative bile duct plasty as the first treatment (83.3%). Although the study was limited by the short follow-up period after DBERC treatment, DBERC is recommended as the first-line treatment for hepatolithiasis associated with biliary and anastomotic strictures in CBD patients, and it can be safely performed multiple times.


2009 ◽  
Vol 75 (2) ◽  
pp. 112-113
Author(s):  
Toshimitsu Fujii ◽  
Shinji Suzuki ◽  
Kiichiro Tsuchiya ◽  
Seishin Azuma ◽  
Shinya Oooka ◽  
...  

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