scholarly journals Erratum to: Cerebral amyloid angiopathy in a young man with a history of traumatic brain injury: a case report and review of the literature

2016 ◽  
Vol 159 (1) ◽  
pp. 19-19
Author(s):  
Yoichi Nakayama ◽  
Yohei Mineharu ◽  
Yoshiki Arakawa ◽  
Sei Nishida ◽  
Hirofumi Tsuji ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Case Report ◽  
Brain Injury ◽  
Cerebral Amyloid Angiopathy ◽  
Amyloid Angiopathy ◽  
Review Of The Literature ◽  
History Of ◽  
Cerebral Amyloid

Cerebral amyloid angiopathy in a young man with a history of traumatic brain injury: a case report and review of the literature

2016 ◽  
Vol 159 (1) ◽  
pp. 15-18 ◽  
Author(s):  
Yoichi Nakayama ◽  
Yohei Mineharu ◽  
Yoshiki Arawaka ◽  
Sei Nishida ◽  
Hirofumi Tsuji ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Case Report ◽  
Brain Injury ◽  
Cerebral Amyloid Angiopathy ◽  
Amyloid Angiopathy ◽  
Review Of The Literature ◽  
History Of ◽  
Cerebral Amyloid

Cyclophosphamide-responsive cerebral amyloid angiopathy-related inflammation. A case report and review of the literature

2013 ◽  
Vol 333 ◽  
pp. e325
Author(s):  
Y. Hagiwara ◽  
T. Yanagisawa ◽  
C. Atsumi ◽  
F. Maki ◽  
T. Shimizu ◽  
...  
Keyword(s):  
Case Report ◽  
Cerebral Amyloid Angiopathy ◽  
Amyloid Angiopathy ◽  
Review Of The Literature ◽  
Cerebral Amyloid

Abstract W MP89: Validation of Clinical-Radiological Criteria for the Diagnosis of Cerebral Amyloid Angiopathy-related Inflammation

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Eitan Auriel ◽  
Mahmut Edip Gurol ◽  
Jun Ni ◽  
Ellis Van Etten ◽  
Sergi Martinez-Remirez ◽  
...  
Keyword(s):  
Sensitivity And Specificity ◽  
Cerebral Amyloid Angiopathy ◽  
Vascular Inflammation ◽  
Brain Biopsy ◽  
Control Group ◽  
Amyloid Angiopathy ◽  
Radiological Criteria ◽  
Disease Subtype ◽  
History Of ◽  
Cerebral Amyloid

Introduction: Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a disease subtype characterized by rapidly progressive cognitive decline, seizures, headaches, T2-hyperintense MRI lesions, and neuropathologic evidence of CAA-associated vascular inflammation. CAA-ri is an important diagnosis to reach in clinical practice, as many patients respond to immunosuppressive therapy. Definitive diagnosis of CAA-ri generally requires brain biopsy, however, highlighting the importance of developing noninvasive diagnostic criteria. Objectives: To test the sensitivity and specificity of modified criteria (Table 1) for possible and probable CAA-ri in groups of subjects with histologically proven CAA-ri and non-CAA-ri. Methods: After refining previously proposed clinical- radiological criteria we retrospectively analyzed clinical charts and MRI FLAIR and gradient-echo scans obtained from 17 subjects with pathologically confirmed CAA-ri and 37 control subjects with pathologic diagnosis of non-inflammatory CAA. The control group was further divided into those with past intracerebral hemorrhage (ICH) (n=21) and those with cerebral microbleeds (CMB) only and no history of ICH (n=16). Results: In the CAA-ri group 14/17 (82.4%) met criteria for both probable and possible CAA-ri. One (4.7%) of the subjects in the control CAA-ICH group (n=21) met the criteria for possible and none met criteria for probable CAA-ri. In the control CAA-no ICH group 1/16 (6.25%) and 11/16 (68.75%) met criteria for probable and possible CAA-ri respectively. This yields sensitivity and specificity of 82% and of 97.3% respectively for the probable criteria and sensitivity and specificity of 82% and 67.6% respectively for the possible criteria. Conclusions: Our data suggest that a reliable diagnosis of CAA-ri can be reached from basic clinical and radiographic information alone with good sensitivity and excellent specificity.

Familial Cerebral Cavernous Malformation Mimicking Cerebral Amyloid Angiopathy

2021 ◽  
pp. 10.1212/CPJ.0000000000001055
Author(s):  
Mohamed Ridha ◽  
Yasmin Aziz ◽  
Joseph Broderick
Keyword(s):  
Cerebral Amyloid Angiopathy ◽  
Cavernous Malformation ◽  
Pathogenic Mutation ◽  
Cerebral Cavernous Malformation ◽  
Amyloid Angiopathy ◽  
History Of ◽  
Cerebral Amyloid ◽  
Cerebral Microhemorrhages ◽  
Familial Cerebral Cavernous Malformation ◽  
Work Up

A 67-year-old man was referred from ophthalmology for possible cerebral amyloid angiopathy (CAA) discovered during work-up of possible optic neuropathy. MRI (figure 1) demonstrated innumerable periventricular, brainstem, and cortical cerebral microhemorrhages (CMH). Scattered, non-specific white matter hyperintensities was seen on T2-weighted imaging without surrounding hypointense rim. He had no hypertension, and the distribution was uncharacteristic for CAA. Despite absent family history of stroke or seizure, testing for familial cerebral cavernous malformation (FCCM) identified a pathogenic mutation of KRIT1 (c.382G>T).

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