Long-term treatment of chronic migraine with OnabotulinumtoxinA: efficacy, quality of life and tolerability in a real-life setting

Unlike many other forms of inflammatory arthritis, the crystal arthropathies are routinely diagnosed and managed in primary care. Gout, in particular, is relatively commonplace and rates of other types of crystal-related arthritis are predicted to increase. These are, therefore, conditions that GPs and trainees will regularly encounter during routine practice. While the clinical features and pathophysiology of gout and pseudo-gout are well described, the long-term treatment goals and options of management are often less well understood, and opportunities to assess for associated co-morbidities can easily be missed. GPs can be central in optimising management by promptly and appropriately addressing acute symptoms, preventing recurrent attacks, minimising disability and work absences, reducing cardiovascular risk factors, improving general health and enhancing quality of life.

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Concerns and Quality of Life of Cancer Survivors Across the Survivorship Trajectory: A Singapore Perspective

10.21203/rs.2.14780/v1 ◽

2019 ◽

Author(s):

Gek Phin Chua ◽

Quan Sing Ng ◽

Hiang Khoon Tan ◽

Whee Sze Ong

Keyword(s):

Quality Of Life ◽

Cancer Survivors ◽

Cancer Treatment ◽

Cancer Survivorship ◽

Recurrence Risk ◽

Term Treatment ◽

Fear Of Recurrence ◽

Long Term Treatment

Abstract Background The aim of this study is to determine the main concerns of survivors at various stages of the cancer survivorship of the cancer survivorship trajectory and to assess whether these concerns have any effect on their quality of life (QOL). The overall goal was to use the insights from the study to guide practice on patient care. Methods A cross-sectional survey of 1107 cancer survivors diagnosed with colorectal, breast, lung, gynaecological, prostate or liver cancers from a cancer centre in Singapore. Eligible patients self-completed a questionnaire adapted from the Mayo Clinic Cancer Centre’s Cancer Survivors Survey of Needs. Results The top 5 concerns among all survivors were cancer treatment and recurrence risk (51%), followed by long-term treatment effects (49%), fear of recurrence (47%), financial concerns (37%) and fatigue (37%). Cancer treatment and recurrence risk, long-term treatment effects and fear of recurrence were amongst the top concerns across the survivorship trajectory. Mean QOL was 7.3 on a scale of 0 – 10. Completed treatment patients had higher QOL score than the newly diagnosed and on treatment patients and the patients dealing with recurrence or second cancer patients. Predictors for QOL included the economic status and housing type of patients and whether patients were concerned with pain and fatigue Conclusion This study confirms that cancer survivors in Singapore face multiple challenges and had various concerns at various stages of cancer survivorship, some of which negatively affect their QOL It is critical to design patient care delivery that appropriately address the various concerns of cancer survivors in order for them to cope and improve their QOL.

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Effects of long-term treatment with Dienogest on the quality of life and sexual function of women affected by endometriosis-associated pelvic pain

Journal of Pain Research ◽

10.2147/jpr.s207599 ◽

2019 ◽

Vol Volume 12 ◽

pp. 2371-2378 ◽

Cited By ~ 13

Author(s):

Salvatore Caruso ◽

Marco Iraci ◽

Stefano Cianci ◽

Salvatore Giovanni Vitale ◽

Valentina Fava ◽

...

Keyword(s):

Quality Of Life ◽

Sexual Function ◽

Pelvic Pain ◽

Term Treatment ◽

Long Term Treatment

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Improved quality of life after long-term treatment with the bisphosphonate ibandronate in patients with metastatic bone disease due to breast cancer

European Journal of Cancer ◽

10.1016/j.ejca.2004.03.025 ◽

2004 ◽

Vol 40 (11) ◽

pp. 1704-1712 ◽

Cited By ~ 119

Author(s):

I.J Diel ◽

J.-J Body ◽

M.R Lichinitser ◽

E.D Kreuser ◽

W Dornoff ◽

...

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Bone Disease ◽

Term Treatment ◽

Metastatic Bone Disease ◽

Long Term Treatment

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Assessment of Quality of Life During Long-Term Treatment of Tolvaptan in Refractory Heart Failure

International Heart Journal ◽

10.1536/ihj.13-326 ◽

2014 ◽

Vol 55 (3) ◽

pp. 264-267 ◽

Cited By ~ 16

Author(s):

Teruhiko Imamura ◽

Koichiro Kinugawa ◽

Tomohito Ohtani ◽

Yasushi Sakata ◽

Taiki Higo ◽

...

Keyword(s):

Quality Of Life ◽

Heart Failure ◽

Term Treatment ◽

Refractory Heart Failure ◽

Long Term Treatment

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What Is a Clinically Relevant Improvement in Quality of Life in Adults With ADHD?

Journal of Attention Disorders ◽

10.1177/1087054715580395 ◽

2015 ◽

Vol 23 (1) ◽

pp. 65-75

Author(s):

Yoko Tanaka ◽

Meryl Brod ◽

Jeannine R. Lane ◽

Himanshu Upadhyaya

Keyword(s):

Quality Of Life ◽

Adult Adhd ◽

Minimal Clinically Important Difference ◽

Term Treatment ◽

Short Term ◽

Treatment Groups ◽

Clinically Important Difference ◽

Long Term Treatment

Objective: To estimate a minimal clinically important difference (MCID) on the adult ADHD Quality of Life (AAQoL) scale. Method: The MCID was determined from data from short-term ( N = 537) and long-term ( N = 440), placebo-controlled atomoxetine trials in adults with ADHD. For the anchor-based approach, change in clinician-rated Clinical Global Impressions–ADHD–Severity (CGI-ADHD-S) scores was used to derive MCID. For the distribution-based approach, baseline-to-endpoint mean ( SD) changes in AAQoL scores corresponding to 0.5 SD were computed. Results: The MCID was similar (approximately 8-point difference) between the short-term and the long-term treatment groups when either the anchor-based or distribution-based approach was used. Conclusion: These results suggest that approximately 8 points in the change from baseline on the AAQoL is a MCID.

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Safety, efficacy and impact on patients’ quality of life of a long-term treatment with α1-blocker alfuzosin in symptomatic patients with BPH.

Current Opinion in Urology ◽

10.1097/00042307-200101000-00031 ◽

2001 ◽

Vol 11 (1) ◽

pp. 113-114

Author(s):

Andrea Tubaro

Keyword(s):

Quality Of Life ◽

Term Treatment ◽

Long Term Treatment ◽

Α1 Blocker

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A pilot study of topiramate in children with Lennox-Gastaut syndrome

Arquivos de Neuro-Psiquiatria ◽

10.1590/s0004-282x1999000200001 ◽

1999 ◽

Vol 57 (2A) ◽

pp. 167-175 ◽

Cited By ~ 13

Author(s):

MARILISA M. GUERREIRO ◽

MARIA LUIZA G. MANREZA ◽

ANNA ELISA SCOTONI ◽

E.A. SILVA ◽

CARLOS A. M. GUERREIRO ◽

...

Keyword(s):

Quality Of Life ◽

Pilot Study ◽

Adjunctive Therapy ◽

Term Treatment ◽

Daily Activities ◽

Efficacy And Safety ◽

Long Term Treatment ◽

Chronic Use

We conducted an open, add-on study with topiramate (TPM) as adjunctive therapy in Lennox-Gastaut syndrome (LGS), to assess the long-term efficacy and safety and to evaluate quality of life (QL) measurements in the chronic use of TPM. We studied 19 patients (11 male; age ranging from 4 to 14 years) with uncontrolled seizures receiving 2-3 anti-epileptic drugs. Patients were followed up to 36 months of treatment. A questionnaire was used to query parents about QL. Seven patients completed the study at 36 months and seizure frequency was reduced > 75% in 4, and < 50% in 3 patients. Two children became seizure free for more than 24 months. Most side effects were CNS related, with the most frequent being somnolence and anorexia. These were generally transient. One patient dropped-out due to powder in the urine. None of the patients required hospitalization. At 36 months, patients' alertness (2/7), interaction with environment (5/7), ability to perform daily activities (5/7), and verbal performance (6/7) improved on TPM. We conclude that TPM may be useful as adjunctive therapy in the treatment of LGS. The efficacy of TPM was maintained in long-term treatment in more than 40% of patients, long term safety was confirmed and QL improved on TPM.

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