Pergolide: treatment of choice in Restless Legs Syndrome (RLS) and Nocturnal Myoclonus Syndrome (NMS). Longterm follow up on pergolide

1998 ◽  
Vol 105 (2-3) ◽  
pp. 265-268 ◽  
Author(s):  
J. Staedt ◽  
H. Hünerjäger ◽  
E. Rüther ◽  
G. Stoppe
Keyword(s):  
Restless Legs Syndrome ◽  
Restless Legs ◽  
Nocturnal Myoclonus Syndrome ◽  
Nocturnal Myoclonus

scholarly journals Time evolution of restless legs syndrome in haemodialysis patients

2019 ◽  
Author(s):  
Irene Capelli ◽  
Fabio Pizza ◽  
Marco Ruggeri ◽  
Lorenzo Gasperoni ◽  
Elisa Carretta ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Kidney Transplantation ◽  
Restless Legs Syndrome ◽  
Statistical Significance ◽  
Dialysis Patients ◽  
Restless Legs ◽  
Continuous Form ◽  
Over Time

Abstract Background Restless legs syndrome (RLS) is characterized by an urge to move the extremities, accompanied by paraesthesiae, in the evening and at night. Uraemic RLS, a type of secondary RLS, occurs commonly in chronic kidney disease and end-stage renal disease. Progression of uraemic RLS over time is unclear. Therefore we investigated the prevalence, progression over time, risk factors and impact on survival of uraemic RLS in a cohort of dialysis patients. Methods We reviewed at the 7-year follow-up a cohort of haemodialysis (HD) patients we had previously investigated for RLS, through interviews, validated questionnaires and analysis of demographic and clinical data. Results At the 7-year follow-up, RLS was present in 16% of patients, with a persistence rate of 33%. A correlation was obtained between RLS and older age, diabetes, low albumin and low body mass index. RLS was associated with reduced overall survival (median survival of 3.3 versus 3.7 years), particularly with the continuous form of RLS (1.61 years). There was a higher incidence of myocardial infarction and peripheral vascular disease, although not reaching statistical significance. RLS patients had absolute higher scores in all quality of life domains. A large majority of study patients (96%) reported being symptom-free within a few days or weeks following kidney transplantation. Conclusions The development of RLS, especially the continuous form, in patients undergoing HD has important consequences associated with decreased survival. Our results indicated an association between uraemic RLS and ageing, diabetes and malnutrition. Considerable efforts should be focused on the treatment of RLS, since it significantly and persistently impacts the quality of life of HD patients. Kidney transplantation could represent an effective treatment option for that RLS impacts on dialysis patients' quality of life, thus confirming the secondary nature of RLS in most HD patients.

scholarly journals Treating Restless Legs Syndrome Was Associated With Low Risk of Cardiovascular Disease: A Cohort Study With 3.4 Years of Follow‐Up

2021 ◽  
Vol 10 (4) ◽  
Author(s):  
Xiang Gao ◽  
Djibril M. Ba ◽  
Kanika Bagai ◽  
Guodong Liu ◽  
Chaoran Ma ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Treatment Group ◽  
Restless Legs Syndrome ◽  
Chronic Conditions ◽  
Medication Use ◽  
Cvd Risk ◽  
Restless Legs ◽  
Age And Sex

Background Restless legs syndrome (RLS) is associated with higher cardiovascular disease (CVD) risk. However, it remains unknown whether treatment of RLS lowers the cardiovascular risk associated with RLS. Methods and Results All data were collected retrospectively, but subjects were prospectively followed forward in time to determine outcomes of interest. We used the Truven Health MarketScan Commercial Claims and Encounters database from January 1, 2006, through December 31, 2014. Participants were 169 393 individuals, which included 24 199 nonpregnant participants with an RLS diagnosis (16 694 receiving treatments for RLS and 7505 without treatment) during 2006 to 2008 and 145 194 age‐ and sex‐matched participants without RLS. All participants were free of CVD before January 1, 2009 (analysis baseline). Incident CVD cases (myocardial infarction, angina, stroke, atrial fibrillation, and heart failure) were identified. We adjusted for potential confounders, such as presence of chronic conditions and medication use. We identified 16 574 incident CVD cases during 2009 to 2014. Relative to the non‐RLS group, the adjusted hazard ratio (HR) for future CVD was 1.26 (95% CI, 1.20–1.32) ( P <0.001) for the RLS with treatment group, and 1.53 (95% CI, 1.42–1.65) ( P <0.001) for the RLS without treatment group. Significant lower CVD risk was observed for all different RLS treatments, including dopaminergics, anticonvulsants, benzodiazepines, and opiates (adjusted HRs range, 0.71‐0.84; P <0.001 for all), except for ergot‐dopamine use. Conclusions RLS was associated with higher future CVD risk. However, RLS was associated with statistically significantly less future cardiovascular risk in RLS patients with treatment than in those without treatment.

Restless legs syndrome is associated with headache-related disabilities in patients with migraine: a prospective 7-year follow-up study

2018 ◽  
Vol 26 (2) ◽  
pp. 238-245 ◽  
Author(s):  
K. Suzuki ◽  
S. Suzuki ◽  
Y. Haruyama ◽  
G. Kobashi ◽  
T. Shiina ◽  
...  
Keyword(s):  
Restless Legs Syndrome ◽  
Restless Legs ◽  
Follow Up Study
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