A Follow-up Study of Rotigotine Patch in Adolescent Subjects With Restless Legs Syndrome

Abstract Background Restless legs syndrome (RLS) is characterized by an urge to move the extremities, accompanied by paraesthesiae, in the evening and at night. Uraemic RLS, a type of secondary RLS, occurs commonly in chronic kidney disease and end-stage renal disease. Progression of uraemic RLS over time is unclear. Therefore we investigated the prevalence, progression over time, risk factors and impact on survival of uraemic RLS in a cohort of dialysis patients. Methods We reviewed at the 7-year follow-up a cohort of haemodialysis (HD) patients we had previously investigated for RLS, through interviews, validated questionnaires and analysis of demographic and clinical data. Results At the 7-year follow-up, RLS was present in 16% of patients, with a persistence rate of 33%. A correlation was obtained between RLS and older age, diabetes, low albumin and low body mass index. RLS was associated with reduced overall survival (median survival of 3.3 versus 3.7 years), particularly with the continuous form of RLS (1.61 years). There was a higher incidence of myocardial infarction and peripheral vascular disease, although not reaching statistical significance. RLS patients had absolute higher scores in all quality of life domains. A large majority of study patients (96%) reported being symptom-free within a few days or weeks following kidney transplantation. Conclusions The development of RLS, especially the continuous form, in patients undergoing HD has important consequences associated with decreased survival. Our results indicated an association between uraemic RLS and ageing, diabetes and malnutrition. Considerable efforts should be focused on the treatment of RLS, since it significantly and persistently impacts the quality of life of HD patients. Kidney transplantation could represent an effective treatment option for that RLS impacts on dialysis patients' quality of life, thus confirming the secondary nature of RLS in most HD patients.

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S12.C Beneficial effects of iron sucrose in restless legs syndrome; a randomised, double-blind, placebo-controlled comparison. One year follow-up

Sleep Medicine ◽

10.1016/s1389-9457(07)70058-8 ◽

2007 ◽

Vol 8 ◽

pp. S19

Author(s):

J. Ulfberg ◽

L. Leissner ◽

L. Grote ◽

J. Hedner

Keyword(s):

Restless Legs Syndrome ◽

Iron Sucrose ◽

Double Blind ◽

Double Blind Placebo ◽

Restless Legs ◽

Beneficial Effects ◽

One Year

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Treating Restless Legs Syndrome Was Associated With Low Risk of Cardiovascular Disease: A Cohort Study With 3.4 Years of Follow‐Up

Journal of the American Heart Association ◽

10.1161/jaha.120.018674 ◽

2021 ◽

Vol 10 (4) ◽

Author(s):

Xiang Gao ◽

Djibril M. Ba ◽

Kanika Bagai ◽

Guodong Liu ◽

Chaoran Ma ◽

...

Keyword(s):

Cardiovascular Disease ◽

Cardiovascular Risk ◽

Treatment Group ◽

Restless Legs Syndrome ◽

Chronic Conditions ◽

Medication Use ◽

Cvd Risk ◽

Restless Legs ◽

Age And Sex

Background Restless legs syndrome (RLS) is associated with higher cardiovascular disease (CVD) risk. However, it remains unknown whether treatment of RLS lowers the cardiovascular risk associated with RLS. Methods and Results All data were collected retrospectively, but subjects were prospectively followed forward in time to determine outcomes of interest. We used the Truven Health MarketScan Commercial Claims and Encounters database from January 1, 2006, through December 31, 2014. Participants were 169 393 individuals, which included 24 199 nonpregnant participants with an RLS diagnosis (16 694 receiving treatments for RLS and 7505 without treatment) during 2006 to 2008 and 145 194 age‐ and sex‐matched participants without RLS. All participants were free of CVD before January 1, 2009 (analysis baseline). Incident CVD cases (myocardial infarction, angina, stroke, atrial fibrillation, and heart failure) were identified. We adjusted for potential confounders, such as presence of chronic conditions and medication use. We identified 16 574 incident CVD cases during 2009 to 2014. Relative to the non‐RLS group, the adjusted hazard ratio (HR) for future CVD was 1.26 (95% CI, 1.20–1.32) ( P <0.001) for the RLS with treatment group, and 1.53 (95% CI, 1.42–1.65) ( P <0.001) for the RLS without treatment group. Significant lower CVD risk was observed for all different RLS treatments, including dopaminergics, anticonvulsants, benzodiazepines, and opiates (adjusted HRs range, 0.71‐0.84; P <0.001 for all), except for ergot‐dopamine use. Conclusions RLS was associated with higher future CVD risk. However, RLS was associated with statistically significantly less future cardiovascular risk in RLS patients with treatment than in those without treatment.

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Restless legs symptoms with sleepiness in relation to mortality: 20-year follow-up study of a middle-aged Swedish population

Psychiatry and Clinical Neurosciences ◽

10.1111/j.1440-1819.2008.01831.x ◽

2008 ◽

Vol 62 (4) ◽

pp. 457-463 ◽

Cited By ~ 30

Author(s):

Lena Mallon ◽

Jan-Erik Broman ◽

Jerker Hetta

Keyword(s):

Middle Aged ◽

Swedish Population ◽

Restless Legs ◽

Follow Up Study

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Restless Legs Syndrome in a Group of Patients With Alzheimer’s Disease

American Journal of Alzheimer s Disease & Other Dementias® ◽

10.1177/1533317512470208 ◽

2012 ◽

Vol 28 (2) ◽

pp. 165-170 ◽

Cited By ~ 11

Author(s):

Giuseppina Talarico ◽

M. Canevelli ◽

G. Tosto ◽

N. Vanacore ◽

F. Letteri ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Neurodegenerative Diseases ◽

Restless Legs Syndrome ◽

Neurological Disorder ◽

Clinical Characteristics ◽

Dopaminergic System ◽

Neuropsychiatric Symptoms ◽

Restless Legs

Background: Restless legs syndrome (RLS) is a neurological disorder characterized by the urge to move the legs associated with peculiar unpleasant sensations during periods of rest and inactivity that are relieved by movement. A few studies analyzed RLS in neurodegenerative diseases such as Alzheimer's Disease (AD). The aim of our study was to assess the prevalence and the clinical characteristics of RLS in a cohort of AD patients. Methods: Three hundred and thirty-nine subjects with a diagnosis of AD were recruited. Cognitive, functional, and neuropsychiatric measures were collected at baseline and six-monthly for a 2-years follow-up Results: Fourteen subjects met the RLS criteria. RLS subjects were more frequently male (p:0,006) and younger than AD subject without RLS (p:0,029). MMSE, ADL and IADL were not significantly different. NPI total scores did not differ significantly, however, AD patients with RLS were found to be more apathetic (p:0,001) than AD subjects without RLS. Conclusion: RLS prevalence in our AD cohort was estimated to be about 4%. RLS appeared to be associated with neuropsychiatric symptoms such as apathy. RLS and apathy might share a common pathophysiological basis represented by a dysfunction of the central dopaminergic system

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Behavioral Changes Associated with Dopamine Agonist Treatment in the Follow-up of Restless Legs Syndrome: A Retrospective Study

Turkiye Klinikleri Journal of Medical Sciences ◽

10.5336/medsci.2021-84596 ◽

2021 ◽

Vol 41 (4) ◽

pp. 438-444

Author(s):

Figen VARLIBAŞ ◽

Gülbün YÜKSEL ◽

Özkan AKHAN ◽

Zeynep BAŞTUĞ GÜL ◽

Burçak ERGİN

Keyword(s):

Retrospective Study ◽

Dopamine Agonist ◽

Restless Legs Syndrome ◽

Behavioral Changes ◽

Restless Legs

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Sleep Disorders and Future Diagnosis of Parkinsonism: A Prospective Study Using the Canadian Longitudinal Study on Aging

Journal of Parkinson s Disease ◽

10.3233/jpd-212796 ◽

2021 ◽

pp. 1-10

Author(s):

Sheida Zolfaghari ◽

Chun W. Yao ◽

Christina Wolfson ◽

Amelie Pelletier ◽

Ronald B. Postuma

Keyword(s):

Longitudinal Study ◽

Prospective Study ◽

Sex Education ◽

Restless Legs Syndrome ◽

Daytime Somnolence ◽

Restless Legs ◽

Obstructive Sleep ◽

New Diagnosis ◽

A Prospective Study

Background: Earlier detection of parkinsonism, specifically during its prodromal stage, may be key to preventing its progression. Previous studies have produced contradictory results on the association between sleep symptoms and prodromal parkinsonism. Objective: We conducted a prospective study within the Canadian Longitudinal Study on Aging (CLSA) to determine whether self-reported symptoms of insomnia, somnolence, apnea, and restless legs syndrome predate the diagnosis of parkinsonism after three years of follow-up. Methods: At baseline, amongst other information, participants completed a questionnaire for difficulty initiating or maintaining sleep, daytime somnolence, snoring or stopping breathing during sleep, and symptoms of restless legs syndrome. After 3 years of follow-up, baseline responses from participants who self-reported a new diagnosis of parkinsonism (cases) were compared to those who did not (controls). For each case, 10 controls were individually matched by age, sex, education, BMI, caffeine, smoking, and alcohol. Binary unconditional logistic regression models were used to estimate the association between sleep symptoms and new-onset parkinsonism, adjusting for age, sex, education, BMI, smoking, alcohol, and caffeine. Results: We identified 58 incident-parkinsonism cases and 580 matched controls (65.5%male, mean age = 69.60, SD = 8.0). Baseline symptoms of sleep-onset insomnia (12.1%vs. 13.0%, Adjusted OR[95%CI] = 0.87[0.32,2.33]), sleep-maintenance insomnia (24.1%vs. 20.2%, AOR = 1.01[0.46,2.20]), daytime somnolence (8.6%vs. 7.4%, AOR = 1.11[0.37,3.39]), obstructive sleep apnea (27.3%vs. 26.2%, AOR = 0.84[0.40,1.79]), and restless leg syndrome (20.6%vs. 9.9%, AOR = 1.34[0.42,4.25]) were similar among those who developed parkinsonism and those who did not. Conclusion: Symptoms of insomnia, somnolence, apnea, and restless legs did not predate a new diagnosis of parkinsonism over 3 years.

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