A highly efficient method for the synthesis of substituted imidazoles from a multicomponent reaction of isatin derivatives with ammonium acetate and aromatic aldehydes under solvent-free conditions has been established.
α-Aminophosphonates were synthesised under solvent-free conditions on an acidic silica gel support using aromatic aldehydes, diethyl phosphite and anhydrous ammonium acetate as starting materials in moderate yields
A simple and benign protocol has been explored for the preparation of 2,4,6-triarylpyridines by a one-pot reaction between aryl aldehydes, enolizable ketones and ammonium acetate in the presence of N-bromosuccinimide or trichloroisocyanuric acid as green and neutral catalysts. The reactions proceed smoothly at 130 °C under solvent-free conditions to provide 2,4,6-triarylpyridines in good yields.
SODIUM BISULFITE AS AN EFFICIENT AND ECONOMICAL CATALYST FOR ONE-POT SYNTHESIS OF 2, 4, 5 TRISUBTITUTED IMIDAZOLES FROM BENZIL, AMMONIUM ACETATE AND AROMATIC ALDEHYDES BY MICROWAVE IRRADIATION