scholarly journals Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection

Amino Acids ◽  
2016 ◽  
Vol 48 (10) ◽  
pp. 2375-2388 ◽  
Author(s):  
Dana M. Hardbower ◽  
Mohammad Asim ◽  
Tracy Murray-Stewart ◽  
Robert A. Casero ◽  
Thomas Verriere ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Macrophage Activation ◽  
Helicobacter Pylori Infection ◽  
Polyamine Metabolism ◽  
M1 Macrophage

scholarly journals Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications

2017 ◽  
Vol 114 (5) ◽  
pp. E751-E760 ◽  
Author(s):  
Dana M. Hardbower ◽  
Mohammad Asim ◽  
Paula B. Luis ◽  
Kshipra Singh ◽  
Daniel P. Barry ◽  
...  
Keyword(s):  
Ornithine Decarboxylase ◽  
Histone Modifications ◽  
Bacterial Infections ◽  
Macrophage Activation ◽  
Ex Vivo ◽  
Polyamine Metabolism ◽  
Mucosal Inflammation ◽  
Macrophage Function ◽  
M1 Macrophage

Macrophage activation is a critical step in host responses during bacterial infections. Ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine metabolism, has been well studied in epithelial cells and is known to have essential roles in many different cellular functions. However, its role in regulating macrophage function during bacterial infections is not well characterized. We demonstrate that macrophage-derived ODC is a critical regulator of M1 macrophage activation during bothHelicobacter pyloriandCitrobacter rodentiuminfection. Myeloid-specificOdcdeletion significantly increased gastric and colonic inflammation, respectively, and enhanced M1 activation. Add-back of putrescine, the product of ODC, reversed the increased macrophage activation, indicating that ODC and putrescine are regulators of macrophage function.Odc-deficient macrophages had increased histone 3, lysine 4 (H3K4) monomethylation, and H3K9 acetylation, accompanied by decreased H3K9 di/trimethylation both in vivo and ex vivo in primary macrophages. These alterations in chromatin structure directly resulted in up-regulated gene transcription, especially M1 gene expression. Thus, ODC in macrophages tempers antimicrobial, M1 macrophage responses during bacterial infections through histone modifications and altered euchromatin formation, leading to the persistence and pathogenesis of these organisms.

1 Arginase II Deletion Enhances Pro-Inflammatory Macrophage Activation and Polyamine Metabolism in Response to Helicobacter pylori

2016 ◽  
Vol 150 (4) ◽  
pp. S1
Author(s):  
Dana M. Hardbower ◽  
Thomas Verriere ◽  
Mohammad Asim ◽  
Nuruddeen Lewis ◽  
Rupesh Chaturvedi ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Macrophage Activation ◽  
Polyamine Metabolism ◽  
Arginase Ii ◽  
Inflammatory Macrophage

DYSPEPSIA SYNDROME AND HELICOBACTER PYLORI INFECTION IN END STAGE RENAL FAILURE

2000 ◽  
Vol 15 (12) ◽  
pp. H2-H2
Author(s):  
IS Mertasudira ◽  
JR Saketi ◽  
A. Djumhana ◽  
J. Widjojo ◽  
SA Abdurachman
Keyword(s):  
Renal Failure ◽  
Helicobacter Pylori ◽  
Helicobacter Pylori Infection ◽  
End Stage Renal Failure ◽  
End Stage

HEMATEMESIS AND MELENA IN BABY WITH HELICOBACTER PYLORI INFECTION

2000 ◽  
Vol 15 (12) ◽  
pp. H10-H11
Author(s):  
Budi Purnomo ◽  
Eva J. Soeleman ◽  
Hadjat S. Digdowirogo ◽  
Hartati N. Soehardjo
Keyword(s):  
Helicobacter Pylori ◽  
Helicobacter Pylori Infection

C14 UREA BREATH TEST DOES NOT CORRELATE WITH HELICOBACTER PYLORI INFECTION DENSITY IN GASTRIC MUCOSA

2000 ◽  
Vol 15 (12) ◽  
pp. H6-H6
Author(s):  
Dinesh Kumar ◽  
V. Ahuja ◽  
C.s Bal ◽  
S.d Gupta ◽  
M. Mathur ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Breath Test ◽  
Urea Breath Test ◽  
Helicobacter Pylori Infection ◽  
Infection Density
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