scholarly journals Expression of concern to: Effects of growth hormone on bone modeling and remodeling in hypophysectomized young female rats: a bone histomorphometric study

Author(s):  
Lysette Iglesias ◽  
James K. Yeh ◽  
Mariano Castro-Magana ◽  
John F. Aloia
1996 ◽  
Vol 28 (6) ◽  
pp. 719-724 ◽  
Author(s):  
V. Aroniadou-Anderjaska ◽  
P.W.R. Lemon ◽  
J. Gilloteaux

2006 ◽  
Vol 51 (3) ◽  
pp. 246-251 ◽  
Author(s):  
Alejandro A. Gorustovich ◽  
Tammy Steimetz ◽  
Máximo J. Giglio ◽  
María B. Guglielmotti

1992 ◽  
Vol 127 (6) ◽  
pp. 531-535 ◽  
Author(s):  
Sumio Takahashi

Growth hormone (GH) release was studied in young (3–4-month-old) and old persistent diestrous (20– 21-month-old) female rats using the reverse hemolytic plaque assay. A bimodal distribution of reverse hemolytic plaque area was observed in both young and old female rats. The mean and median of the plaque area of GH cells from old females were smaller than those from young female rats. The percentage of plaque-forming GH cells in old female rats was lower than in young female rats. The percentage of large plaque-forming GH cells (plaque area, more than 8 × 103 μm2) was lower in old female rats than in young female rats. GH-releasing hormone (GHRH) increased the mean and median of plaque areas in both young and old female rats. However, responsiveness to GHRH was reduced in old female rats. These results indicate that the amount of GH released from individual GH cells decreases with age in female rats, resulting in diminished GH secretion.


1966 ◽  
Vol 35 (4) ◽  
pp. 379-383 ◽  
Author(s):  
S. SYMCHOWICZ ◽  
W. D. PECKHAM ◽  
R. ONERI ◽  
C. A. KORDUBA ◽  
P. L. PERLMAN

SUMMARY Anterior pituitaries from young female rats were incubated in Krebs-Ringer solution at 37° for 4·5–5 hr. A purified acetic acid extract of pig hypothalami was added, at various concentrations, to the incubation medium. The results show that the purified hypothalamic preparation increased the growth-hormone content in the supernatant of pituitary homogenates, suggesting an enhancement of hormone synthesis by the hypothalamic preparation. It is also suggested that the hypothalamic extract when incubated with pituitaries causes an increase in the rate of the release of growth hormone with prolonged incubation.


2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Alejandro Adrian Gorustovich ◽  
Tammy Steimetz ◽  
Forrest H Nielsen ◽  
María B Guglielmotti

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