The change of bone mineral density in secondary osteoporosis and vertebral fracture incidence

1999 ◽  
Vol 17 (2) ◽  
pp. 119-124 ◽  
Author(s):  
Yuji Hirano ◽  
Hideaki Kishimoto ◽  
Hiroshi Hagino ◽  
Ryota Teshima
Keyword(s):  
Bone Mineral Density ◽  
Vertebral Fracture ◽  
Bone Mineral ◽  
Fracture Incidence ◽  
Secondary Osteoporosis ◽  
Mineral Density ◽  
Vertebral Fracture Incidence

scholarly journals Continuing Relief of Pain with Long Term Treatment for Osteoporosis with Intravenous Pamidronate

2018 ◽  
Vol 4 (1) ◽  
pp. 51-58
Author(s):  
Wilson S ◽  
Sharp CA ◽  
Davie MWJ
Keyword(s):  
Bone Mineral Density ◽  
Vertebral Fracture ◽  
Side Effects ◽  
Bone Mineral ◽  
Oral Treatment ◽  
Fracture Incidence ◽  
Mineral Density ◽  
Intravenous Pamidronate ◽  
Vertebral Fracture Incidence

Purpose: Bisphosphonates are valuable in reducing the incidence of fracture. Side effects limit persistence with oral therapy and long term studies of pain relief are difficult to pursue. Intravenous bisphosphonates offer an alternative treatment to oral bisphosphonates and are tolerated over a longer period. The use of Pamidronate, an intravenously administered bisphosphonate, to benefit pain and reduce fracture incidence in the long term has not been extensively investigated. The study aimed to investigate the effect of Pamidronate on pain, vertebral fracture incidence and Bone Mineral Density over 6 or more years.Methods: Patients were offered intravenous Pamidronate if oral treatment with bisphosphonates or Hormone replacement therapy had failed due to side effects, fractures continued on oral treatment or oesophageal reflux led to cessation of oral treatment. Pain was assessed using the Nottingham health profile; radiographs were used to evaluate vertebral fracture and DXA measured bone mineral density.Results: The primary outcome was the pain domain. Median patient follow up was 9 years. Pain had improved significantly (p = 0.03) and in 68% pain had either improved or remained unchanged. Vertebral fractures occurred in 14% of patients in the first 3 years, 9.5% in years 4-6, but increased in years 7-9 to 27%. Bone mineral density increased in the lumbar spine (p < 0.001) but not at the femoral neck.Conclusions: Pamidronate had a beneficial effect on pain over the period of the study. Vertebral fracture incidence increased after 6 years of Pamidronate, although spine BMD increased significantly.

scholarly journals Heterogeneity of Bone Mineral Density and Fatigue Failure of Human Vertebrae

2012 ◽  
Author(s):  
Yener N. Yeni ◽  
Laila M. Poisson ◽  
Michael J. Flynn
Keyword(s):  
Mechanical Properties ◽  
Bone Mineral Density ◽  
Vertebral Fracture ◽  
Bone Mineral ◽  
Vertebral Fractures ◽  
Important Determinant ◽  
Fatigue Properties ◽  
Static Properties ◽  
Mineral Density ◽  
Significant Interest

Bone qualities that are measurable via clinically available modalities and that can explain fracture risk beyond what is explainable by bone mineral density (BMD) are of significant interest. Evidence from literature suggests that the heterogeneity of BMD within a vertebra, in addition to the average BMD, may be an important determinant of the mechanical properties of a vertebra 1–3 and risk of a clinical vertebral fracture 4. Much of the experimental evidence comes from tests, in which vertebrae are monotonically loaded and relates BMD heterogeneity to the quasi-static properties of a vertebra 1, 3. The appearance of clinical vertebral fractures is in the form of progressive deformities indicating that fatigue processes are involved. However, the relationships between BMD heterogeneity and fatigue properties of a vertebra are not well-understood.

Association of PLXNA2 polymorphisms with vertebral fracture risk and bone mineral density in postmenopausal Korean population

2006 ◽  
Vol 17 (11) ◽  
pp. 1592-1601 ◽  
Author(s):  
J. -Y. Hwang ◽  
J. -Y. Lee ◽  
M. -H. Park ◽  
K. -S. Kim ◽  
K. -K. Kim ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vertebral Fracture ◽  
Fracture Risk ◽  
Bone Mineral ◽  
Korean Population ◽  
Mineral Density ◽  
Vertebral Fracture Risk
Sign in / Sign up

Export Citation Format

Share Document